Fatty acid and lipoprotein transport in hepatocytes (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none LysosomeMitochondrionEndoplasmic reticulumEndosomeMitochondrial beta-oxidationPeroxisomal beta-oxidationMicrosomal omega-oxidationCholesterol biosynthesisLong-chain fatty acidLong-chain fatty acidDiffusionFatty acyl-CoAEndocytosisCell membranesCholesterol esterCholesterol esterCholesterol esterCholesterol esterCholesterol esterCholesterol esterCholesterol esterCholesterol esterCholesterol esterCholesterol esterCholesterol esterCholesterol esterCholesterol esterAPOBAPOEAPOA1APOA2APOA4APOBAPOC1APOC2APOC3APOEAPOA1APOC1APOA2APOC1APOEAPOBAPOEAPOBAPOA1APOA2APOC1APOBAPOELRPAP1SORT1MYLIPAPOBLCATDBILIPANPC2TSPOSORT1APOBSCARB1APOBAPOEABCA1SORT1APOA1MTTPLPAAPOBTriacylglycerolTriacylglycerolTriacylglycerolTriacylglycerolTriacylglycerolTriacylglycerolTriacylglycerolSecretionLDLLDLChylomicronChylomicron remnantNascent HDLHDLVLDLIDLLDLLP(a)LP(a)VLDLPhospholipidsPhospholipidPhospholipidsPhospholipidsPhospholipidsCholesterol esterCholesterolCholesterolCholesterolCholesterolCholesterolCoAMembraneHepatocyteChylomicronremnantLDLRAP1APOBLDLRLDLRPCSK9APOELRP1LDLRPCSK9LDLRPCSK9Long-chain fatty acidFABPLong-chain fatty acidCD36Long-chain fatty acidSLC27A2SLC27A4SLC27A3SLC27A5SLC27A1STARD3VDAC1STARD3VAPANPC1OSBPL5ACSL1ACSL3ACSL4ACSL5ACSL6LACsFABP2FABP3FABP5FABP1FABP4Fatty acid binding proteinDBIFatty acyl-CoASOAT1SOAT2SOATVDAC1STARCD36Extracellular matrixCytosolMembraneExtracellular matrixCytosolLDLLP(a)IDLVLDLHDLChylomicronremnantNascentHDLChylomicronLipiddropletVLDLLDLHDLName: Fatty acid and lipoprotein transport in hepatocytesOrganism: Homo sapiens


Description

This model was constructed integrating the Fatty acid transporters (Homo sapiens) metapathway (WP5061), the Cholesterol metabolism (Homo sapiens) (WP5304) and the KEGG Cholesterol metabolism pathway (map04979) as well as information from the literature.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : classic metabolic pathway
 

Bibliography

  1. Stahl A; ''A current review of fatty acid transport proteins (SLC27).''; Pflugers Arch, 2004 PubMed Europe PMC Scholia
  2. Nguyen P, Leray V, Diez M, Serisier S, Le Bloc'h J, Siliart B, Dumon H; ''Liver lipid metabolism.''; J Anim Physiol Anim Nutr (Berl), 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135704view16:40, 27 October 2024EweitzOmit non-standard, formulaic, hidden complex names
135588view12:45, 4 October 2024EweitzImprove readability of lipid labels
135587view12:29, 4 October 2024EweitzColor lipids
135586view12:18, 4 October 2024EweitzModified title
135585view12:17, 4 October 2024EweitzGroup Lp(a) membrane genes / proteins
135584view12:13, 4 October 2024EweitzEconomize layout
135583view11:46, 4 October 2024EweitzAdd "Hepatocyte" label
135582view11:32, 4 October 2024EweitzFormally group genes / proteins in each lipid particle membrane
135581view02:25, 4 October 2024EweitzRefine positioning
135580view02:22, 4 October 2024EweitzLabel cytosol, membrane, extracellular matrix
135579view02:08, 4 October 2024EweitzStandardize pathway node graphics
135578view01:09, 4 October 2024EweitzEconomize layout
135577view01:01, 4 October 2024EweitzEconomize layout
135576view00:55, 4 October 2024EweitzEconomize layout
135575view00:48, 4 October 2024EweitzEconomize layout
135574view00:36, 4 October 2024EweitzEconomize layout
135573view00:20, 4 October 2024EweitzEconomize layout
135572view11:33, 3 October 2024EweitzStandardize case
135571view11:31, 3 October 2024EweitzRefine lipid border: single layer, not bilayer
135570view11:26, 3 October 2024EweitzEconomize layout
135569view11:12, 3 October 2024EweitzClear cache to update board dimensions
135568view11:12, 3 October 2024EweitzEconomize layout
135567view10:43, 1 October 2024EweitzEconomize layout
135566view17:31, 29 September 2024EweitzEconomize size of lipid nodes
135565view13:32, 29 September 2024EweitzStandardize node graphics
135564view02:01, 28 September 2024EweitzEconomize layout, standardize node graphics
135563view11:57, 26 September 2024EweitzEconomize layout
135562view11:43, 26 September 2024EweitzEconomize layout, standardize node graphics
135561view11:16, 26 September 2024EweitzEconomize layout, standardize node graphics
135558view01:57, 25 September 2024EweitzEconomize layout, standardize node graphics
135557view00:10, 25 September 2024EweitzEconomize layout
135556view11:53, 24 September 2024EweitzEconomize layout, standardize node graphics
135555view03:24, 24 September 2024EweitzEconomize layout, standardize node graphics
135554view02:41, 24 September 2024EweitzEconomize layout, standardize node graphics
135538view03:36, 23 September 2024EweitzTailor node widths, fix typo
129339view09:12, 27 March 2024MkutmonOntology Term : 'classic metabolic pathway' added !
128432view18:00, 4 February 2024EweitzModified title
127176view08:16, 9 August 2023EgonwRemoved redundant whitespace
127175view08:07, 9 August 2023EgonwThinner lines
125909view16:28, 17 March 2023JmillanacostaRemoved "Pathway" node
125823view18:26, 12 March 2023EgonwMoved a KEGG pathway identifier from interaction ID to source comment
125747view10:08, 9 March 2023DeSlChanged last MIM-conversion to PW nodes to Arrow
125746view10:06, 9 March 2023DeSlConverting MIM-conversion to arrows between PW node interactions
125745view08:55, 9 March 2023DeSlConverted lines from several enzymes to MIM-catalysis
125580view05:40, 1 March 2023EgonwFixed the WikiPathways data source casing
125520view07:02, 25 February 2023EgonwFixed the upper case of a data source
125424view14:21, 13 February 2023Mkutmonliterature reference information added
125402view16:11, 11 February 2023LLadeiraOntology Term : 'CL:0019028' removed !
125401view16:11, 11 February 2023LLadeiraOntology Term : 'midzonal region hepatocyte' added !
125400view16:11, 11 February 2023LLadeiraOntology Term : 'centrilobular region hepatocyte' added !

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ABCA1ProteinNM_005502 (RefSeq)
ACSL1Protein2180 (Entrez Gene)
ACSL3ProteinNM_004457 (RefSeq)
ACSL4Protein3571 (HGNC Accession number)
ACSL5ProteinENSG00000197142 (Ensembl)
ACSL6ProteinENSG00000164398 (Ensembl)
APOA1Protein600 (HGNC Accession number)
APOA2Protein601 (HGNC Accession number)
APOA4ProteinAPOA4 (HGNC)
APOBProtein338 (Entrez Gene)
APOC1ProteinNM_001321065 (RefSeq)
APOC2ProteinP02655 (Uniprot-TrEMBL)
APOC3Protein610 (HGNC Accession number)
APOEProteinENSG00000130203 (Ensembl)
CD36Protein1663 (HGNC Accession number)
Cell membranesPathwayGO:0044091 (GeneOntology) A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane.
Cholesterol biosynthesisPathwayGO:0006695 (GeneOntology) The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
Cholesterol esterMetaboliteCHEBI:17002 (ChEBI)
CholesterolMetaboliteCHEBI:16113 (ChEBI)
Chylomicron remnantPathwayGO:0034360 (GeneOntology) A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver.
ChylomicronPathwayGO:0042627 (GeneOntology) A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.
CoAMetaboliteCHEBI:15346 (ChEBI)
DBIProteinDBI (HGNC)
DiffusionPathwayGO:0022803 (GeneOntology) Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged.
EndocytosisPathwayGO:0006897 (GeneOntology) A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
FABPProtein
FABP1ProteinNM_001443 (RefSeq)
FABP2ProteinNM_000134 (RefSeq)
FABP3ProteinENSG00000121769 (Ensembl)
FABP4ProteinNM_001442 (RefSeq)
FABP5Protein3560 (HGNC Accession number)
Fatty acyl-CoAMetaboliteCHEBI:37554 (ChEBI)
HDLPathwayGO:0034364 (GeneOntology) A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.
IDLPathwayGO:0034363 (GeneOntology) A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL).
LCATProtein6522 (HGNC Accession number)
LDLPathwayGO:0034362 (GeneOntology) A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver.
LDLRAP1ProteinENSG00000157978 (Ensembl)
LDLRProteinLDLR (HGNC)
LIPAProteinLIPA (HGNC)
LP(a)Pathway
LPAProteinENSG00000198670 (Ensembl)
LRP1ProteinNM_002332 (RefSeq)
LRPAP1Protein6701 (HGNC Accession number)
Long-chain fatty acidMetaboliteCHEBI:15904 (ChEBI)
MTTPProtein7467 (HGNC Accession number)
MYLIPProteinNM_013262 (RefSeq)
Microsomal omega-oxidationPathwayWP206 (WikiPathways) A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation.
Mitochondrial beta-oxidationPathwayGO:0006635 (GeneOntology) A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
NPC1Protein7897 (HGNC Accession number)
NPC2ProteinENSG00000119655 (Ensembl)
Nascent HDLPathwayGO:0034364 (GeneOntology) A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.
OSBPL5ProteinENSG00000021762 (Ensembl)
PCSK9ProteinQ8NBP7 (Uniprot-TrEMBL)
Peroxisomal beta-oxidationPathwayGO:0006635 (GeneOntology) A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
PhospholipidMetaboliteCHEBI:16247 (ChEBI)
PhospholipidsMetaboliteCHEBI:16247 (ChEBI)
SCARB1ProteinQ8WTV0 (Uniprot-TrEMBL)
SLC27A1Protein376497 (Entrez Gene)
SLC27A2Protein11001 (Entrez Gene)
SLC27A3ProteinNM_024330 (RefSeq)
SLC27A4ProteinENSG00000167114 (Ensembl)
SLC27A5Protein10999 (HGNC Accession number)
SOAT1ProteinSOAT1 (HGNC)
SOAT2ProteinNM_003578 (RefSeq)
SORT1Protein6272 (Entrez Gene)
STARD3ProteinQ14849 (Uniprot-TrEMBL)
STARProteinSTAR (HGNC)
SecretionPathway
TSPOProtein1158 (HGNC Accession number)
TriacylglycerolMetaboliteCHEBI:17855 (ChEBI)
VAPAProtein12648 (HGNC Accession number)
VDAC1ProteinENSG00000213585 (Ensembl)
VLDLPathwayGO:0034361 (GeneOntology) A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver.

Annotated Interactions

View all...
Source  ↓Target  ↓Type  ↓Database reference  ↓Comment  ↓
Cholesterol esterCholesterol estermim-conversionWP5304 (WikiPathways)
Cholesterol esterCholesterolArrowWP5304 (WikiPathways)
CholesterolCholesterolArrowWP5304 (WikiPathways)
CholesterolCholesterolmim-conversionWP5304 (WikiPathways)
CholesterolNascent HDLArrowWP5304 (WikiPathways)
ChylomicronChylomicron remnantArrowWP5304 (WikiPathways)
ChylomicronNascent HDLArrowWP5304 (WikiPathways)
HDLVLDLArrowWP5304 (WikiPathways)
IDLLDLArrowWP5304 (WikiPathways)
LDLLP(a)ArrowWP5304 (WikiPathways)
LP(a)LP(a)ArrowWP5304 (WikiPathways)
LRPAP1LRP1mim-modificationWP5304 (WikiPathways)
Long-chain fatty acidmim-bindingWP5061 (WikiPathways)
Nascent HDLHDLArrowWP5304 (WikiPathways)
VLDLArrowWP5304 (WikiPathways)
VLDLIDLArrowWP5304 (WikiPathways)
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