Neural crest development (Danio rerio)

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1, 2, 5, 6neural crest specifiersmelanin synthesisInduction signalsiridophoresbranchial archespteridin syntesisglianeural plate border specifiersenteric neuronspigmentationqdprawnt8adlx5amsxepax3aslc45a2oca2pcbd1zic3kitasilvabcmo1sox9bdlx4bltkret1dlx3bplp1bmbpgchfrdlx2asilvbegr2bsprapax7azic2asox10dlx3bbmp7ambzphox2bmsxbptstyrsnai1bcsf1rmsxcdctmitfazic5qdprb1kitbplp1atwist1bfoxd3bmp2bzic1zic2bednrb1tfap2amycatyrp1bdlx4bgch2slc24a5id2aaox3dlx1atwist1apahdlx4abmp7b43


This pathway displays genes required for different processes in neural crest development. It is based on genetic and signaling interactions.

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  1. Meulemans D, Bronner-Fraser M; ''Central role of gene cooption in neural crest evolution.''; J Exp Zoolog B Mol Dev Evol, 2005 PubMed Europe PMC Scholia
  2. Donoghue PC, Graham A, Kelsh RN; ''The origin and evolution of the neural crest.''; Bioessays, 2008 PubMed Europe PMC Scholia
  3. Lopes SS, Yang X, Muller J, Carney TJ, McAdow AR, Rauch GJ, Jacoby AS, Hurst LD, Delfino-Machín M, Haffter P, Geisler R, Johnson SL, Ward A, Kelsh RN; ''Leukocyte tyrosine kinase functions in pigment cell development.''; PLoS Genet, 2008 PubMed Europe PMC Scholia
  4. Lampert JM, Holzschuh J, Hessel S, Driever W, Vogt K, von Lintig J; ''Provitamin A conversion to retinal via the beta,beta-carotene-15,15'-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis.''; Development, 2003 PubMed Europe PMC Scholia
  5. Meulemans D, Bronner-Fraser M; ''Gene-regulatory interactions in neural crest evolution and development.''; Dev Cell, 2004 PubMed Europe PMC Scholia
  6. Gammill LS, Bronner-Fraser M; ''Neural crest specification: migrating into genomics.''; Nat Rev Neurosci, 2003 PubMed Europe PMC Scholia


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73522view23:34, 29 January 2014KhanspersModified title
70147view21:31, 12 July 2013MaintBotupdated to 2013 schema
70146view21:30, 12 July 2013MaintBotremoved problematic characters
67505view11:10, 26 June 2013DdiglesOntology Term : 'signaling pathway pertinent to development' added !
40860view22:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
29821view08:55, 3 June 2009GwoModified description
29516view15:30, 11 May 2009GwoMinor changes
29515view15:28, 11 May 2009GwoAnnotation update
29417view11:48, 6 May 2009GwoAnnotation update
29415view11:40, 6 May 2009GwoUpdate annotation
29413view11:33, 6 May 2009GwoAnnotation update
29412view11:25, 6 May 2009GwoModified categories
29411view11:24, 6 May 2009GwoModified categories
29410view11:21, 6 May 2009GwoModified categories
26481view14:32, 3 December 2008GwoModified description
26479view14:29, 3 December 2008GwoUpdated pathway
26477view14:23, 3 December 2008GwoChanged comments
26475view14:19, 3 December 2008GwoExtended the original pathway with more genes
26473view13:41, 3 December 2008GwoModified description
21832view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:Neural crest tutorial gwo]] moved to [[Pathway:WP548]]: Moved to stable identifier
19083view10:03, 17 September 2008GwoNew pathway

External references


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NameTypeDatabase referenceComment
aox3GeneProduct64265 (Entrez Gene)
bcmo1GeneProduct84039 (Entrez Gene)
bmp2bGeneProduct30632 (Entrez Gene)
bmp7aGeneProduct30584 (Entrez Gene)
bmp7bGeneProduct557567 (Entrez Gene)
csf1rGeneProduct64274 (Entrez Gene)
dctGeneProduct58074 (Entrez Gene)
dlx1aGeneProduct30568 (Entrez Gene)
dlx2aGeneProduct30574 (Entrez Gene)
dlx3bGeneProduct30585 (Entrez Gene)
dlx4aGeneProduct30561 (Entrez Gene)
dlx4bGeneProduct30581 (Entrez Gene)
dlx5aGeneProduct30569 (Entrez Gene)
ednrb1GeneProduct30442 (Entrez Gene)
egr2bGeneProduct30190 (Entrez Gene)
foxd3GeneProduct30548 (Entrez Gene)
gch2GeneProduct64263 (Entrez Gene)
gchfrGeneProduct393735 (Entrez Gene)
id2aGeneProduct266599 (Entrez Gene)
kitaGeneProduct30256 (Entrez Gene)
kitbGeneProduct497629 (Entrez Gene)
ltkGeneProduct564470 (Entrez Gene)
mbpGeneProduct326281 (Entrez Gene)
mbzGeneProduct114417 (Entrez Gene)
mitfaGeneProduct30080 (Entrez Gene)
msxbGeneProduct30511 (Entrez Gene)
msxcGeneProduct30526 (Entrez Gene)
msxeGeneProduct30527 (Entrez Gene)
mycaGeneProduct30686 (Entrez Gene)
oca2GeneProduct567419 (Entrez Gene)
pahGeneProduct378962 (Entrez Gene)
pax3aGeneProduct30532 (Entrez Gene)
pax7aGeneProduct30587 (Entrez Gene)
pcbd1GeneProduct393787 (Entrez Gene)
phox2bGeneProduct544654 (Entrez Gene)
plp1aGeneProduct64264 (Entrez Gene)
plp1bGeneProduct368234 (Entrez Gene)
ptsGeneProduct100073330 (Entrez Gene)
qdpraGeneProduct566323 (Entrez Gene)
qdprb1GeneProduct791448 (Entrez Gene)
ret1GeneProduct30512 (Entrez Gene)
silvaGeneProduct321239 (Entrez Gene)
silvbGeneProduct562810 (Entrez Gene)
slc24a5GeneProduct570312 (Entrez Gene)
slc45a2GeneProduct558311 (Entrez Gene)
snai1bGeneProduct30182 (Entrez Gene)
sox10GeneProduct140616 (Entrez Gene)
sox9bGeneProduct60642 (Entrez Gene)
spraGeneProduct554136 (Entrez Gene)
tfap2aGeneProduct140618 (Entrez Gene)
twist1aGeneProduct30175 (Entrez Gene)
twist1bGeneProduct550518 (Entrez Gene)
tyrGeneProduct30207 (Entrez Gene)
tyrp1bGeneProduct437022 (Entrez Gene)
wnt8aGeneProduct30122 (Entrez Gene)
zic1GeneProduct30096 (Entrez Gene)
zic2aGeneProduct58077 (Entrez Gene)
zic2bGeneProduct570746 (Entrez Gene)
zic3GeneProduct368263 (Entrez Gene)
zic5GeneProduct403041 (Entrez Gene)

Annotated Interactions

No annotated interactions

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