Pathways into methionine and folate cycles (Homo sapiens)

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Cobalamin (B12) and folate (B9) are two B vitamins that are essential for the folate cycle and methionine cycle, which are part of one-carbon metabolism. The folate cycle is located in the cytoplasm and mitochondria, and uses serine and glycine as inputs. The folate cycle is dependent on B12 to generate the active forms of vitamin B9. The methionine cycle requires methionine to produce cysteine, which is a key component of the trans-sulfuration pathway. The enzyme methionine synthase uses B12 as a cofactor to convert homocysteine to methionine.

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History

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CompareRevisionActionTimeUserComment
135731view22:46, 31 October 2024AlexanderPicoremoved stray comment
135730view22:46, 31 October 2024AlexanderPicoModified title
135729view22:46, 31 October 2024AlexanderPicoModified description
135487view00:00, 20 September 2024EweitzModified title
135340view23:25, 26 August 2024Alexmadsen1New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
10-formyl-THFMetaboliteCHEBI:15637 (ChEBI)
5, 10-MTHFPGMetaboliteCHEBI:60976 (ChEBI)
5-10MeTHFMetaboliteCHEBI:20502 (ChEBI)
5-MTHFMetaboliteCHEBI:15641 (ChEBI)
ABCD4ProteinO14678 (Uniprot-TrEMBL) cblJ
AHCYProteinP23526 (Uniprot-TrEMBL)
ALDH1L2ProteinQ3SY69 (Uniprot-TrEMBL)
ALPIProteinP09923 (Uniprot-TrEMBL) Intestinal-type alkaline phosphatase
ALPLProteinP05186 (Uniprot-TrEMBL)
AMNProteinQ9BXJ7 (Uniprot-TrEMBL) aka amnionless
AOX1ProteinQ06278 (Uniprot-TrEMBL) Aldehyde oxidase
AdoCblMetaboliteCHEBI:18408 (ChEBI)
B2MetaboliteCHEBI:17015 (ChEBI)
B9MetaboliteCHEBI:27470 (ChEBI)
BHMTProteinQ93088 (Uniprot-TrEMBL)
CBLIFProteinP27352 (Uniprot-TrEMBL)
  • aka (gastric) intrinsic factor, transcobalamin III
  • Located in gastric parietal cells
CBSProteinP35520 (Uniprot-TrEMBL)
CD320ProteinQ9NPF0 (Uniprot-TrEMBL) Aka CD320 receptor
CUBNProteinO60494 (Uniprot-TrEMBL) aka cubilin
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CblMetaboliteCHEBI:23334 (ChEBI)
DHFMetaboliteCHEBI:23743 (ChEBI)
DHFRProteinP00374 (Uniprot-TrEMBL)
DNMT1ProteinP26358 (Uniprot-TrEMBL)
FADMetaboliteCHEBI:57692 (ChEBI) cofactor
FLAD1MetaboliteQ8NFF5 (ChEBI)
FMNMetabolitecHEBI:58210 (ChEBI)
FOLH1GeneProductQ04609 (Uniprot-TrEMBL)
FOLR1ProteinP15328 (Uniprot-TrEMBL)
FOLR2ProteinP14207 (Uniprot-TrEMBL)
GNMTProteinQ14749 (Uniprot-TrEMBL)
HCFC1 (cblX)GeneProductP51610 (Uniprot-TrEMBL)
LMBRD1ProteinQ9NUN5 (Uniprot-TrEMBL) cblF
MAT1AProteinQ00266 (Uniprot-TrEMBL)
MAT2BProteinQ9NZL9 (Uniprot-TrEMBL)
MMAAProteinQ8IVH4 (Uniprot-TrEMBL) cbLA
MMABProtein60488 (Uniprot-TrEMBL) cblB
MMACHCProteinQ9Y4U1 (Uniprot-TrEMBL) cbLC
MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
MMUTProteinP22033 (Uniprot-TrEMBL) aka methylmalonyl-CoA mutase or MCM
MTHFD1ProteinP11586 (Uniprot-TrEMBL)
MTHFRProteinP42898 (Uniprot-TrEMBL)
MTRProteinQ99707 (Uniprot-TrEMBL)
MTRRProteinQ9UBK8 (Uniprot-TrEMBL)
MeCbl(III)alaminMetaboliteCHEBI:28115 (ChEBI)
MetMetaboliteCHEBI:64558 (ChEBI)
Methylmalonyl-CoAMetaboliteCHEBI:16625 (ChEBI)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
Mo-MPTMetaboliteCHEBI:71302 (ChEBI) Mo-molybdopterin
NGLY1ProteinQ96IV0 (Uniprot-TrEMBL) PNG hydrolase, PNGH
PAMetaboliteCHEBI:17405 (ChEBI) 4-pyridoxic acid
PDXKProteinO00764 (Uniprot-TrEMBL)
PLMetaboliteCHEBI:17310 (ChEBI) pyridoxal
PLPMetaboliteCHEBI:597326 (ChEBI) pyridoxal 5'-phosphate
PMMetaboliteCHEBI:57761 (ChEBI) pyridoxamine
PMPMetaboliteCHEBI:18335 (ChEBI) pyridoxamine 5'-phosphate
PNMetaboliteCHEBI:28803 (ChEBI) pyridoxine, vitamin B6
PNGMetaboliteCHEBI:17382 (ChEBI) pyridoxine-5′-β-D-glucoside
PNPMetaboliteCHEBI:28803 (ChEBI) pyridoxine 5′-phosphate
PNPOProteinQ9NVS9 (Uniprot-TrEMBL)
R-cob(III)alaminMetaboliteCHEBI:140785 (ChEBI)
RFKProteinQ969G6 (Uniprot-TrEMBL)
SAHMetaboliteCHEBI:16680 (ChEBI)
SAMe MetaboliteCHEBI:59789 (ChEBI)
SHMT1ProteinP34896 (Uniprot-TrEMBL)
SLC19A1ProteinP41440 (Uniprot-TrEMBL)
SLC46A1ProteinQ96NT5 (Uniprot-TrEMBL)
SLC52A1GeneProductQ9NWF4 (Uniprot-TrEMBL)
SLC52A2GeneProductQ9HAB3 (Uniprot-TrEMBL)
SLC52A3GeneProductQ9NQ40 (Uniprot-TrEMBL)
SLC?Protein
Succinyl-CoAMetaboliteCHEBI:15380 (ChEBI)
TCN1ProteinP20061 (Uniprot-TrEMBL)
  • aka haptocorrin or transcobalamin 1
  • Produced in saliva and stomach
TCN2ProteinP20062 (Uniprot-TrEMBL) aka Transcobalamin 2
THF-polyglutamateMetaboliteCHEBI:28624 (ChEBI)
THFMetaboliteCHEBI:26907 (ChEBI)
TYMSProteinP04818 (Uniprot-TrEMBL)
Zn2+MetaboliteCHEBI:29105 (ChEBI)
acetateMetaboliteCHEBI:58251 (ChEBI)
cbLA MMAAProteinQ8IVH4 (Uniprot-TrEMBL) Gene: MMAA
cob(I)alaminMetaboliteCHEBI:15982 (ChEBI)
cob(II)alaminMetaboliteCHEBI:16304 (ChEBI) Should be cob(II)alamin according to literature
cobalamins MetaboliteCHEBI:23334 (ChEBI)
cystathionineMetaboliteCHEBI:58161 (ChEBI)
glycine betaineMetaboliteCHEBI:17750 (ChEBI)
glycineMetaboliteCHEBI:57305 (ChEBI)
homocysteineMetaboliteCHEBI:58199 (ChEBI)
hydroxocobalaminMetaboliteCHEBI:27786 (ChEBI)
sarcosineMetaboliteCHEBI:57433 (ChEBI)
serineMetaboliteQ82980657 (Wikidata)
vitamin B12Metabolite
vitamin B6MetaboliteCHEBI:27306 (ChEBI)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
SAMe SAHmim-conversion13681 (Rhea) a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
SAMe SAHmim-conversion19937 (Rhea) glycine + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + sarcosine
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5488"
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