Targeted therapy in breast cancer (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NucleusTucatinibMEKKRASHRASNRASRAF1MAP2K1MAP2K2MAP2K3MAP2K4MAP2K5MAP2K6MAP2K7RASSurvivalProliferationCell-cycle progressionPIK3CAPIK3CBPIK3CGPIK3CDClass 1 catalyticPIK3R1PIK3R2PIK3R3PIK3R4Class 1 regulatoryPIK3R5PIK3R6PIK3C2APIK3C2BPIK3C2GClass 2PIK3C2AClass 3PI3KAKT1AKT2AKT3AKTERKMAPK1MAPK3PEGFRPEGFRPERBB2PEGFRPERBB2PERBB3PERBB2PERBB4PERBB2PERBB2LapatinibNeratinibPyrotinibTrastuzumabPertuzumabNeratinibPyrotinibName: Targeted therapy in breast cancerOrganism: Homo sapiens


Description

"Trastuzumab and pertuzumab inhibit HER2 signaling by binding to the extracellular domain of HER2. Lapatinib, neratinib, tucatinib, and pyrotinib inhibit HER signaling by binding to the intracellular tyrosine kinase domain of the Her family members.". Source: Figure F1, https://pmc.ncbi.nlm.nih.gov/articles/PMC9281252/. Derived from PFOCR, https://pfocr.wikipathways.org/figures/PMC9281252__12032_2022_1749_Fig1_HTML.html.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Cell Type : osteoblast
 

Bibliography

  1. Demir Cetinkaya B, Biray Avci C; ''Molecular perspective on targeted therapy in breast cancer: a review of current status.''; Med Oncol, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137728
Approved
view12:09, 7 March 2025EweitzModified description
135813view00:21, 12 November 2024EweitzFix PI3K node
135812view00:10, 12 November 2024EweitzOntology Term : 'luminal epithelial cell of mammary gland' added !
135811view00:10, 12 November 2024EweitzOntology Term : 'mammary gland epithelial cell' added !
135810view00:07, 12 November 2024EweitzOntology Term : 'drug pathway' added !
135809view00:07, 12 November 2024EweitzOntology Term : 'breast cancer pathway' added !
135808view00:07, 12 November 2024EweitzOntology Term : 'breast cancer' added !
135807view00:05, 12 November 2024EweitzEmphasize drug interactions
135806view00:05, 12 November 2024EweitzIdentify tucatinib
135805view00:02, 12 November 2024EweitzRemove less relevant comments
135804view00:01, 12 November 2024EweitzRefine layout
135803view00:00, 12 November 2024EweitzRefine layout
135802view23:57, 11 November 2024EweitzLabel organelle, economize layout
135801view23:33, 11 November 2024EweitzAdd more interactions
135800view23:19, 11 November 2024EweitzAdd drugs, phosphorylation states
135799view22:31, 11 November 2024EweitzAdd cell, surface protein dimers
135798view22:09, 11 November 2024EweitzImport AKT family
135797view22:04, 11 November 2024EweitzImprove organization
135796view21:52, 11 November 2024EweitzImport PI3K family
135794view19:56, 11 November 2024EweitzImport parts of RAS / MAPK pathway
135793view19:50, 11 November 2024EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ERBB2GeneProductENSG00000141736 (Ensembl)
ERBB3GeneProductENSG00000065361 (Ensembl)
ERBB4GeneProductENSG00000178568 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
LapatinibMetaboliteCHEBI:49603 (ChEBI)
MAP2K1GeneProductENSG00000107356 (Ensembl)
MAP2K2GeneProductENSG00000101418 (Ensembl)
MAP2K3GeneProductENSG00000107958 (Ensembl)
MAP2K4GeneProductENSG00000115669 (Ensembl)
MAP2K5GeneProductENSG00000138015 (Ensembl)
MAP2K6GeneProductENSG00000129652 (Ensembl)
MAP2K7GeneProductENSG00000118907 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
NeratinibMetaboliteCHEBI:61397 (ChEBI)
PIK3C2AGeneProductENSG00000011405 (Ensembl)
PIK3C2BGeneProductENSG00000133056 (Ensembl)
PIK3C2GGeneProductENSG00000139144 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIK3R4GeneProductENSG00000196455 (Ensembl)
PIK3R5GeneProductENSG00000141506 (Ensembl)
PIK3R6GeneProductENSG00000276231 (Ensembl)
PertuzumabMetaboliteDB06366 (DrugBank)
PyrotinibMetaboliteDB14993 (DrugBank)
RAF1GeneProductENSG00000132155 (Ensembl)
TrastuzumabMetaboliteDB00072 (DrugBank)
TucatinibMetaboliteDB11652 (DrugBank)

Annotated Interactions

No annotated interactions

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