Targeted therapy in breast cancer (Homo sapiens)
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Description
"Trastuzumab and pertuzumab inhibit HER2 signaling by binding to the extracellular domain of HER2. Lapatinib, neratinib, tucatinib, and pyrotinib inhibit HER signaling by binding to the intracellular tyrosine kinase domain of the Her family members.". Source: Figure F1, https://pmc.ncbi.nlm.nih.gov/articles/PMC9281252/. Derived from PFOCR, https://pfocr.wikipathways.org/figures/PMC9281252__12032_2022_1749_Fig1_HTML.html.
Quality Tags
Ontology Terms
Pathway Ontology : G protein mediated signaling pathway
Bibliography
- Demir Cetinkaya B, Biray Avci C; ''Molecular perspective on targeted therapy in breast cancer: a review of current status.''; Med Oncol, 2022 PubMed Europe PMC Scholia
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Annotated Interactions
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