NSAIDs mechanism of action (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Non-selective NSAIDsTissue injuryArachidonic acidPTGS1PTGS2AngiogenesisCell proliferationMetastasisDiclofenacIbuprofenNaproxenPTGS2PGD2PGE2PGF2aPGI2PGG2PGH2PGA1PGE1PGE2PGE2InflammationPainHemostasisProtection ofgastric mucosaCelecoxibRofecoxibCOX2-selective NSAIDsName: NSAIDs mechanism of actionOrganism: Homo sapiens


Description

Nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting the cyclooxygenase enzymes PTGS1 (COX-1) and PTGS2 (COX-2), with different NSAIDs showing varying selectivity for the COX-2 isoform. This inhibition blocks the conversion of arachidonic acid into prostaglandins (PGs). Inspired by Figure 1 in PMID:32322101.

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

Bibliography

  1. Schjerning AM, McGettigan P, Gislason G; ''Cardiovascular effects and safety of (non-aspirin) NSAIDs.''; Nat Rev Cardiol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139179view13:02, 24 May 2025EweitzModified description
139178
Approved
view12:58, 24 May 2025EweitzRefine gene identifiers
136464view13:09, 3 February 2025EweitzModified description
136463view13:08, 3 February 2025EweitzOntology Term : 'drug pathway' added !
136462view13:07, 3 February 2025EweitzWiden nodes
136461view13:07, 3 February 2025EweitzWiden node
136460view13:06, 3 February 2025EweitzWiden node
136459view13:06, 3 February 2025EweitzRemove anchor
136458view13:05, 3 February 2025EweitzConnect downstream effects
136457view13:01, 3 February 2025EweitzAdd literature reference
136456view13:00, 3 February 2025EweitzAdd more nodes, interactions, labels
136454view03:08, 3 February 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AngiogenesisPathwayWP1539 (WikiPathways)
Arachidonic acidMetabolite
CelecoxibMetaboliteDB00482 (DrugBank)
Cell proliferationQ189101 (Wikidata)
DiclofenacMetaboliteDB00586 (DrugBank)
HemostasisQ487937 (Wikidata)
IbuprofenMetaboliteDB01050 (DrugBank)
InflammationQ101991 (Wikidata)
MetastasisQ181876 (Wikidata)
NaproxenMetaboliteDB00788 (DrugBank)
PGA1MetaboliteCHEBI:15545 (ChEBI)
PGD2MetaboliteCHEBI:15555 (ChEBI)
PGE1MetaboliteCHEBI:15544 (ChEBI)
PGE2MetaboliteCHEBI:15551 (ChEBI)
PGF2aMetaboliteCHEBI:15553 (ChEBI)
PGG2MetaboliteCHEBI:27647 (ChEBI)
PGH2MetaboliteCHEBI:15554 (ChEBI)
PGI2MetaboliteCHEBI:15552 (ChEBI)
PTGS1GeneProductENSG00000095303 (Ensembl) "COX1" in source
PTGS2GeneProductENSG00000073756 (Ensembl) "COX2" in source
PainQ81938 (Wikidata)
Protection of gastric mucosaQ383249 (Wikidata)
RofecoxibMetaboliteDB00533 (DrugBank)
Tissue injuryQ21119857 (Wikidata)

Annotated Interactions

No annotated interactions

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