LncRNA-like NMRK2 in translocation renal cell carcinoma (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NucleusLncRNA-like NMRK2 mRNA binds to miRNAs and upregulates SLC19A2, a novel NAD+ transport thatlocalizes to mitochondrial membrane.Antisense binding inhibits translationGAS5 is a lncRNA that normally inhibits mitochrondrial respiration. In NONO-TFE3 tRCC, lncRNA-like NMRK2 mRNA binds to GAS5. This blocks GAS5 inhibition, andincreases mitochondrial activity.NAD+TCA cycleCancer progressionATPMALAT1NONOTFE3NMRK2SLC19A2FHMDH2CSGAS5HSPE1MALAT1NMRK2SLC19A2FumarateCitrateNAD+ATPUnfoldedproteinresponseATPNONO-TFE3 fusionprotein upregulatesNMRK2 and MALAT1Proposed NONO-TFE3 tRCC treatment:Inhibition of lncRNA like NMRK2 mRNALncRNA-like NMRK2 binds to HSPE1 (Hsp10),and stabilizes it. This enhances the role ofHSPE1 in mitochondrial unfolded protein response(mtUPR), which increases mitochondrial activity.Kidney cellName: LncRNA-like NMRK2 in translocation renal cell carcinomaOrganism: Homo sapiens


Description

NMRK2 mRNA acts as a long non-coding RNA (lncRNA) and enhancing mitochondrial respiration in NONO-TFE3 translocation renal cell carcinoma (tRCC). NMRK2 functions as a molecular scaffold to promote mitochondrial function in these cancer cells, independent of NAD+ kinase activity. NMRK2 upregulation contributes to tumor progression by improving cellular energy production through enhanced mitochondrial respiration. Targeting NMRK2 might help treat this aggressive RCC subtype.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : classic metabolic pathway
 

Bibliography

  1. Chen Y, Lu Y, Yang L, Ma W, Dong Y, Zhou S, Liu N, Gan W, Li D; ''LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD(+) kinase-independent manner.''; J Exp Clin Cancer Res, 2023 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138119
Approved
view13:24, 15 March 2025EweitzAdd literature reference
138118view13:22, 15 March 2025EweitzOntology Term : 'cancer' added !
138117view13:22, 15 March 2025EweitzOntology Term : 'neoplastic cell' added !
138116view13:22, 15 March 2025EweitzOntology Term : 'kidney cell' added !
138115view13:21, 15 March 2025EweitzLabel nucleus, cell type
138114view13:17, 15 March 2025EweitzAdd identifiers for pathways
138113view13:15, 15 March 2025EweitzAdd identifiers for metabolites
138112view13:08, 15 March 2025EweitzAdd identifiers for genes
138111view12:58, 15 March 2025EweitzOntology Term : 'TFE3-rearranged renal cell carcinoma' added !
138110view12:57, 15 March 2025EweitzOntology Term : 'renal cell carcinoma' added !
138109view12:56, 15 March 2025EweitzModified description
138108view12:49, 15 March 2025EweitzRefine interactions
138107view12:47, 15 March 2025EweitzRefine text
138106view12:44, 15 March 2025EweitzRefine text
138105view12:43, 15 March 2025EweitzAdd explanatory text
138104view12:33, 15 March 2025EweitzAdd explanatory text
138103view12:16, 15 March 2025EweitzAdd explanatory text
138102view11:58, 15 March 2025EweitzColor lncRNA, refine interactions
138101view11:47, 15 March 2025EweitzAdd pathways, ATP, cancer progression
138100view01:49, 15 March 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ATPMetaboliteCHEBI:15422 (ChEBI)
CSGeneProductENSG00000062485 (Ensembl)
Cancer progression
CitrateMetaboliteCHEBI:16947 (ChEBI)
FHGeneProductENSG00000091483 (Ensembl)
FumarateMetaboliteCHEBI:29806 (ChEBI)
GAS5GeneProduct
HSPE1GeneProductENSG00000115541 (Ensembl)
MALAT1GeneProductENSG00000251562 (Ensembl)
MDH2GeneProductENSG00000146701 (Ensembl)
NAD+MetaboliteCHEBI:15846 (ChEBI)
NMRK2GeneProductENSG00000077009 (Ensembl)
NONOGeneProductENSG00000147140 (Ensembl)
SLC19A2GeneProductENSG00000117479 (Ensembl)
TCA cyclePathwayWP78 (WikiPathways)
TFE3GeneProductENSG00000068323 (Ensembl)
Unfolded

protein

response		PathwayWP4925 (WikiPathways)

Annotated Interactions

No annotated interactions

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