Blood-based neuroinflammation markers (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Blood-brain barrier disruption and vascular endothelial injuryMicroglial activationNeurotrophic factorsGlial activationNeurotoxic metabolitesSystemic innate-immune mediatorsAcute-phase proteinsNeuronal injury markersKynurenine pathway metabolitesAstrocyte activationChemokinesNeuroinflammation markersNeuromodulators and neuropeptidesCytokinesADMCX3CL1CRPCCL11CCL5S100BTREM2DBICHI3L1GFAPOLR1NEFLQuinolinic acidTSPOBDNFTAC1CCL23CCL2IL1BIL6GRNTREM1TNFGFAPS100BName: Blood-based neuroinflammation markersOrganism: Homo sapiens


Description

This figure presents a comprehensive overview of molecular markers associated with neuroinflammation, specifically focusing on potential blood-based markers. Markers are organized by biological function and relevance to specific neuroimmune processes. The markers are grouped into seven categories, including systemic innate-immune mediators; blood–brain barrier (BBB) disruption and vascular endothelial injury; glial activation, which is subdivided into astrocyte and microglial activation; neuromodulators and neuropeptides; neuronal injury markers; the neurotoxic metabolite quinolinic acid, a neuroactive product of the kynurenine pathway; and neurotrophic factors.

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Quality Tags

Image:NonTypical.pngAnnotated lists
Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
139121
Approved
view02:48, 22 May 2025EweitzModified title
139120view02:47, 22 May 2025EweitzStandardize case
139088view14:49, 19 May 2025Kristof-KirpsModified description
139079view09:24, 19 May 2025Kristof-KirpsFixed References
139078view09:23, 19 May 2025Mkutmonfix reference
139077view09:18, 19 May 2025Kristof-KirpsFixed Titel
139076view09:12, 19 May 2025Kristof-KirpsOntology Term : 'blood cell' added !
139075view09:10, 19 May 2025Kristof-KirpsOntology Term : 'long COVID' added !
139074view09:09, 19 May 2025Kristof-KirpsOntology Term : 'cytokine and chemokine mediated signaling pathway' added !
139073view09:07, 19 May 2025Kristof-KirpsOntology Term : 'nervous system disease pathway' added !
139072view09:07, 19 May 2025Kristof-KirpsOntology Term : 'immune system disease pathway' added !
139071view09:03, 19 May 2025Kristof-KirpsNew pathway

External references

DataNodes

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Name  ↓Type  ↓Database reference  ↓Comment  ↓
ADMProteinP35318 (Uniprot-TrEMBL)
BDNFProteinP23560 (Uniprot-TrEMBL)
CCL11ProteinP51671 (Uniprot-TrEMBL)
CCL23ProteinP55773 (Uniprot-TrEMBL)
CCL2ProteinP13500 (Uniprot-TrEMBL)
CCL5ProteinP13501 (Uniprot-TrEMBL)
CHI3L1ProteinP36222 (Uniprot-TrEMBL)
CRPProteinP02741 (Uniprot-TrEMBL)
CX3CL1ProteinP78423 (Uniprot-TrEMBL)
DBIProteinP07108 (Uniprot-TrEMBL)
GFAPProteinP14136 (Uniprot-TrEMBL)
GRNProteinP28799 (Uniprot-TrEMBL)
IL1BProteinP01584 (Uniprot-TrEMBL)
IL6ProteinP05231 (Uniprot-TrEMBL)
NEFLProteinP07196 (Uniprot-TrEMBL)
OLR1ProteinP78380 (Uniprot-TrEMBL)
Quinolinic acidMetaboliteCHEBI:16675 (ChEBI)
S100BProteinP04271 (Uniprot-TrEMBL)
TAC1ProteinP20366 (Uniprot-TrEMBL)
TNF ProteinP01375 (Uniprot-TrEMBL)
TREM1ProteinQ9NP99 (Uniprot-TrEMBL)
TREM2ProteinQ9NZC2 (Uniprot-TrEMBL)
TSPOProteinP30536 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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