Suzetrigine mechanism for pain relief (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ExtracellularBrainPain signal(Action potential)Na+PainSCN10ANa+Na+SCN10ANa+Na+Na+Na+Na+Na+Na+Na+Na+Na+Na+Na+Na+Na+SCN10ASuzetrigineNa+Na+Na+Na+Na+Na+Na+Na+Na+Na+Na+Na+Na+Pain signal(Action potential)IntracellularExtracellularIntracellularNociceptorNociceptorSuzetrigineSCN10ASpinal cordPain signal(Action potential)Dorsal rootganglionNociceptorName: Suzetrigine mechanism for pain reliefOrganism: Homo sapiens


Description

Suzetrigine (trade name Journavx) is an oral medication used to manage moderate to severe acute pain. It is a non-opioid, small-molecule analgesic that functions by selectively inhibiting Nav1.8-dependent pain signaling pathways in the peripheral nervous system. Unlike opioids, suzetrigine is non-addictive. Inspired by Figure 2 in [Cho et al. (2025)](https://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147(25)00028-8).

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Bibliography

  1. Cho, Eun Bee, Jiang, Chenyao, Wang, Zihan, Yu, Ying, Jiang, Jianxiong; ''Suzetrigine for moderate to severe acute pain ''; Trends in Phamacological Sciences, 2025

History

View all...
CompareRevisionActionTimeUserComment
139163
Approved
view12:15, 24 May 2025EweitzFill identifier gaps
139161view02:03, 24 May 2025EweitzOntology Term : 'peripheral sensory neuron' added !
139160view02:03, 24 May 2025EweitzOntology Term : 'drug pathway' added !
139159view02:02, 24 May 2025EweitzModified description
139158view02:01, 24 May 2025EweitzAdd literature reference
139157view02:00, 24 May 2025EweitzModified description
139156view01:59, 24 May 2025EweitzModified description
139155view01:48, 24 May 2025EweitzModified title
139154view01:48, 24 May 2025EweitzOntology Term : 'sensory neuron of dorsal root ganglion' added !
139153view01:47, 24 May 2025EweitzOntology Term : 'pain receptor cell' added !
139152view01:45, 24 May 2025EweitzRefine mask positions
139151view01:41, 24 May 2025EweitzClear dimension cache
139150view01:41, 24 May 2025EweitzEconomize layout
139149view00:13, 24 May 2025EweitzRefine arrow positions
139148view00:12, 24 May 2025EweitzCorrect cell type labels
139147view00:02, 24 May 2025EweitzAdd identifiers for drugs, metabolites
139146view23:55, 23 May 2025EweitzRefine mask positions
139145view23:53, 23 May 2025EweitzLabel DRG, refine graphics
139144view23:37, 23 May 2025EweitzAdd graphics for dorsal root ganglion, spinal cord cross section
139143view12:05, 23 May 2025EweitzEnhance graphics
139142view11:51, 23 May 2025EweitzEnhance nervous system graphics
139138view03:55, 23 May 2025EweitzAdd action potential
139137view03:53, 23 May 2025EweitzFix PathVisio / Kaavio graphical discrepancy
139136view03:51, 23 May 2025EweitzBegin nervous system graphics
139135view03:04, 23 May 2025EweitzNew pathway

External references

DataNodes

Name  ↓Type  ↓Database reference  ↓Comment  ↓
Na+MetaboliteCHEBI:29101 (ChEBI)
PainQ81938 (Wikidata)
SCN10AGeneProductENSG00000185313 (Ensembl)
SuzetrigineMetaboliteDB18927 (DrugBank)

Annotated Interactions

No annotated interactions

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