Lupus therapies (Homo sapiens)

From WikiPathways

Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ComplementfactorsImmune complexDapirolizumabpegolBI655064IanalumabB cellAutoantibodiesCD40MHC IICD40LGTCRMHCIL17AIL17BIL17CIL17DIL25IL17FIL6T cellDendriticcellTCRPlasma cellNeutrophilMacrophageCD86CD80CD28RituximabOcrelizumabObinutuzumabOfatumumabObexelimabInebilizumabEpratuzumabDaratumumabMezagitamabBelimumabIanalumabTabalumabAtaciceptTelitaciceptUstekinumabGuselkumabSecukinumabSirukumabVobarilizumabTocilizumabCD19CD22MS4A1CD38IL6RTNFSF13BIL23AIL23BIL12AIL12BIFNGC1QAC1QBC1QCC2C3C4AC4BGlomerular cellAMG 811CTLA4-IgName: Lupus therapiesOrganism: Homo sapiens


Description

Therapeutic approaches in systemic lupus erythematosus (SLE) increasingly focus on modulating B and T cell activity.

B cell–directed therapies involve targeting specific surface receptors such as CD19, CD20, CD22, CD38, and CD40, as well as blocking B cell-related cytokines like BAFF (B-cell activating factor, also known as TNFSF13B). T cell-focused strategies include blocking co-stimulatory pathways (e.g. CD40–CD40L, CD80/86–CD28, ICOS–ICOSL) and inhibiting pro-inflammatory cytokines, including IL-6, IL-12, IL-17, IL-23, and IFN-γ.

Inspired by Figure 1 in [Su et al. (2024)](https://pmc.ncbi.nlm.nih.gov/articles/PMC11522254/).

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Su X, Yu H, Lei Q, Chen X, Tong Y, Zhang Z, Yang W, Guo Y, Lin L; ''Systemic lupus erythematosus: pathogenesis and targeted therapy.''; Mol Biomed, 2024 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139318view19:11, 31 May 2025EweitzClear dimension cache
139317view18:59, 31 May 2025EweitzShow T cell acting on macrophage and neutrophil
139291view22:21, 30 May 2025EweitzAdd literature reference
139290view22:15, 30 May 2025EweitzFix interaction
139289view22:15, 30 May 2025EweitzEconomize layout
139286view02:22, 30 May 2025EweitzModified description
139285view01:49, 30 May 2025EweitzModified description
139284view01:45, 30 May 2025EweitzModified description
139283view01:40, 30 May 2025EweitzOntology Term : 'lupus erythematosus' added !
139282view01:39, 30 May 2025EweitzOntology Term : 'drug pathway' added !
139281view01:36, 30 May 2025EweitzOntology Term : 'glomerular cell' added !
139280view01:36, 30 May 2025EweitzOntology Term : 'plasma cell' added !
139279view01:35, 30 May 2025EweitzOntology Term : 'neutrophil' added !
139278view01:35, 30 May 2025EweitzOntology Term : 'macrophage' added !
139277view01:35, 30 May 2025EweitzOntology Term : 'dendritic cell' added !
139276view01:34, 30 May 2025EweitzOntology Term : 'T cell' added !
139275view01:34, 30 May 2025EweitzOntology Term : 'B cell' added !
139274view01:16, 30 May 2025EweitzRemove database name for metabolites without identifers
139273view01:12, 30 May 2025EweitzEconomize layout
139272view00:39, 30 May 2025EweitzAdd identifiers for drugs
139271view00:08, 30 May 2025EweitzUse generic names, not internal proprietary names
139270view23:37, 29 May 2025EweitzAdd interactions, economize layout
139255view01:32, 29 May 2025EweitzAdd interactions, glomerular cell
139245view01:20, 28 May 2025EweitzAdd complement factors
139243view00:35, 28 May 2025EweitzAdd interleukins, drug interactions
139242view01:56, 27 May 2025EweitzArrange drugs, genes
139241view00:38, 27 May 2025EweitzAdd genes, drugs; arrange
139240view23:36, 26 May 2025EweitzAdd drugs
139239view13:00, 26 May 2025EweitzAdd genes
139238view12:58, 26 May 2025EweitzAdd cells
139237view12:57, 26 May 2025EweitzAdd cells, genes
139236view12:51, 26 May 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AMG 811Metabolite
AtaciceptMetaboliteDB06399 (DrugBank)
AutoantibodiesGeneProductQ785022 (Other)
BI655064Metabolite
BelimumabMetaboliteDB08879 (DrugBank)
C1QAGeneProductENSG00000173372 (Ensembl)
C1QBGeneProductENSG00000173369 (Ensembl)
C1QCGeneProductENSG00000159189 (Ensembl)
C2GeneProductENSG00000166278 (Ensembl)
C3GeneProductENSG00000125730 (Ensembl)
C4AGeneProductENSG00000244731 (Ensembl)
C4BGeneProductENSG00000224389 (Ensembl)
CD19GeneProductENSG00000177455 (Ensembl)
CD22GeneProductENSG00000012124 (Ensembl)
CD28GeneProductENSG00000178562 (Ensembl)
CD38GeneProductENSG00000004468 (Ensembl)
CD40GeneProductENSG00000101017 (Ensembl)
CD40LGGeneProductENSG00000102245 (Ensembl) "CD40L" in source
CD80GeneProductENSG00000121594 (Ensembl)
CD86GeneProductENSG00000114013 (Ensembl)
CTLA4-IgMetabolite
Dapirolizumab pegolMetaboliteDB16131 (DrugBank)
DaratumumabMetaboliteDB09331 (DrugBank)
EpratuzumabMetaboliteDB04958 (DrugBank)
GuselkumabMetaboliteDB11834 (DrugBank)
IFNGGeneProductENSG00000111537 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl) "IL17" in source
IL12BGeneProductENSG00000113302 (Ensembl) "IL17" in source
IL17AGeneProductENSG00000112115 (Ensembl) "IL17" in source
IL17BGeneProductENSG00000127743 (Ensembl) "IL17" in source
IL17CGeneProductENSG00000124391 (Ensembl) "IL17" in source
IL17DGeneProductENSG00000172458 (Ensembl) "IL17" in source
IL17FGeneProductENSG00000112116 (Ensembl) "IL17" in source
IL23AGeneProductENSG00000110944 (Ensembl)
IL23BGeneProductENSG00000113302 (Ensembl)
IL25GeneProductENSG00000166090 (Ensembl) "IL17" in source
IL6GeneProductENSG00000136244 (Ensembl)
IL6RGeneProductENSG00000160712 (Ensembl)
IanalumabMetaboliteDB16666 (DrugBank) "VAY736" in source
Immune complexGeneProduct
InebilizumabMetaboliteDB12530 (DrugBank) "MEDI551" in source
MHC IIGeneProduct
MHCGeneProduct
MS4A1GeneProductENSG00000156738 (Ensembl) "CD20" in source
MezagitamabMetaboliteDB16370 (DrugBank)
ObexelimabMetaboliteDB15032 (DrugBank) "XmAb5871" in source
ObinutuzumabMetaboliteDB08935 (DrugBank)
OcrelizumabMetaboliteDB11988 (DrugBank)
OfatumumabMetaboliteDB06650 (DrugBank)
RituximabMetaboliteDB00073 (DrugBank)
SecukinumabMetaboliteDB09029 (DrugBank)
SirukumabMetaboliteDB14891 (DrugBank) "CNTO 136" in source
TCRGeneProduct
TNFSF13BGeneProductENSG00000102524 (Ensembl) "BAFF" in source
TabalumabMetaboliteDB11657 (DrugBank)
TelitaciceptMetaboliteDB18312 (DrugBank)
TocilizumabMetaboliteDB06273 (DrugBank)
UstekinumabMetaboliteDB05679 (DrugBank)
VobarilizumabMetaboliteDB14891 (DrugBank) "ALX-0061" in source

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5560"
Personal tools