Integrative Analysis of Treg-Glial Interactions (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none FOXP3AREG/EGFR/GSK-3ß pathwayNeuroprotection and cell survivalDopaminergic neuronLegendIL-10RRegulatory T cell (Treg)PI3K/Akt-pathwayOPC differentiationOPC migrationMARKERS TregsTGFßRB7ChemotaxisTGF-ßActin remodeling and cell migrationA2B5RAC1/Akt-pathwayDAMAGEMHC/AgMicroglia phenotipic change:"Reparative microglia"TCRTNFR2PI3K/Akt-pathwayIL-35PI3K/Akt/mTor pathwayOligodendrogenesisOligodendrocyteBindingMAPK-pathwayCell proliferation TregsExpression of pro-inflammatory cytokinesOigodendrocyte precursor cell (OPC)Damage BBBIL-33RMicrogliaAntigen-presenting cell (APC)MAPK/ERK-pathwayMARKERS OPCsIL-2RMARKERS OligodendrocytenPSTAT3MOGCNPCSPG4FOXO4TNFIGF1CCL20IL33CTLA4LGALS1CCL1CCR8IL2NKX6-2OLIG2serotonineMAPK14SPP1IGF1RIL10NOS2CCN3FOXP3SIRPAKLRG1CXCL1OSMIGF1IKZF2PDGFANKX2-2NKX6-1SOX9GALCEGFRMBPOLIG2HTR7CCR6PDGFRACD47CD274AREGTNFRSF1BMMP9IL4PDCD1OLIG1PLP1CD4CD28PSMAD2PSMAD3CD80CD86ITGB3ITGAVITGA2MCAMLGALS3IGF1IL1RAPSSTR2CXCL12SEMA3FPNFKB2PNFKB1PJAK1PTYK2PSTAT1PSTAT4IL2RBIL2RGIL2RAPTYK2PJAK1TGFBR2TGFBR1TGFBR3TRBC2TRBC1TRACFOXO1FOXO3TGM2VEGFAPJAK1PJAK3IL1BTNFROS1IFNGglutamateFAM20Cnitric oxideIL12AEBI3IL10RAIL10RBTGFB2TGFB1PSTAT5ASTAT5BNFKB2NFKB1IL12RB1IL12RB2IL-35RSPP1InflammationDNAPhagocytosisPI3K/Akt pathwayIntegrinR αVβ3Pro-inflammatory cytokinesMARKERS MicrogliaGasdermin poreCD68PTK2MYD88TLR4AIF1P2RY12RAC1IL6CASP1IFNGGSDMDNFKB2NFKB1TMEM119SOCS3IL18CX3CR1NLRP3APODCDC42IL1BHEXBTNFCD44MAPK/ERK pathwayJAK/STAT3 pathwayIL1BREPAIROPC proliferationMicroglial activityConversionStimulation/activationSecretionReceptorXProtein/gene productXXMetaboliteXXSecretion productMarkersName: Integrative Analysis of Treg-Glial InteractionsOrganism: Homo sapiens


Description

Interaction_Regulatory T cells_Microglia_Oligodendrocyte precursor cells_Oligodendrocytes

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
139461
Approved
view03:32, 19 June 2025EgonwRemoved duplicate BioPax fields
139448view14:53, 17 June 2025KhanspersOntology Term : 'signaling pathway' added !
139385view17:50, 11 June 2025Khanspersfixed unconnected interactions
139375view15:18, 9 June 2025EgonwModified title
139328view10:11, 2 June 2025FienValentaModified title
139269view15:26, 29 May 2025FienValentaOntology Term : 'signaling pathway pertinent to the brain and nervous system' added !
139268view14:57, 29 May 2025FienValentaModified title
139267view14:53, 29 May 2025FienValentaNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AIF1GeneProductENSG00000204472 (Ensembl)
APODGeneProductENSG00000189058 (Ensembl)
AREGGeneProductENSG00000109321 (Ensembl)
CASP1GeneProductENSG00000137752 (Ensembl)
CCL1GeneProductENSG00000108702 (Ensembl)
CCL20GeneProductENSG00000115009 (Ensembl)
CCN3GeneProductENSG00000136999 (Ensembl)
CCR6GeneProductENSG00000112486 (Ensembl)
CCR8GeneProductENSG00000179934 (Ensembl)
CD274GeneProductENSG00000120217 (Ensembl)
CD28GeneProductENSG00000178562 (Ensembl)
CD44GeneProductENSG00000026508 (Ensembl)
CD47GeneProductENSG00000196776 (Ensembl)
CD4GeneProductENSG00000010610 (Ensembl)
CD68GeneProductENSG00000129226 (Ensembl)
CD80GeneProductENSG00000121594 (Ensembl)
CD86GeneProductENSG00000114013 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CNPGeneProductENSG00000173786 (Ensembl)
CSPG4GeneProductENSG00000173546 (Ensembl)
CTLA4GeneProductENSG00000163599 (Ensembl)
CX3CR1GeneProductENSG00000168329 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
EBI3GeneProductENSG00000105246 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
FAM20CGeneProductENSG00000177706 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FOXO3GeneProductENSG00000118689 (Ensembl)
FOXO4GeneProductENSG00000184481 (Ensembl)
FOXP3GeneProductENSG00000049768 (Ensembl)
GALCGeneProductENSG00000054983 (Ensembl)
GSDMDGeneProductENSG00000104518 (Ensembl)
HEXBGeneProductENSG00000049860 (Ensembl)
HTR7GeneProductENSG00000148680 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl)
IGF1RGeneProductENSG00000140443 (Ensembl)
IKZF2GeneProductENSG00000030419 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL10RAGeneProductENSG00000110324 (Ensembl)
IL10RBGeneProductENSG00000243646 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12RB1GeneProductENSG00000096996 (Ensembl)
IL12RB2GeneProductENSG00000081985 (Ensembl)
IL18GeneProductENSG00000150782 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1RAPGeneProductENSG00000196083 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
IL2RAGeneProductENSG00000134460 (Ensembl)
IL2RBGeneProductENSG00000100385 (Ensembl)
IL2RGGeneProductENSG00000147168 (Ensembl)
IL33GeneProductENSG00000137033 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
ITGA2GeneProductENSG00000164171 (Ensembl)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JAK3GeneProductENSG00000105639 (Ensembl)
KLRG1GeneProductENSG00000139187 (Ensembl)
LGALS1GeneProductENSG00000100097 (Ensembl)
LGALS3GeneProductENSG00000131981 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MBPGeneProductENSG00000197971 (Ensembl)
MCAMGeneProductENSG00000076706 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MOGGeneProductENSG00000204655 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
NKX2-2GeneProductENSG00000125820 (Ensembl)
NKX6-1GeneProductENSG00000163623 (Ensembl)
NKX6-2GeneProductENSG00000148826 (Ensembl)
NLRP3GeneProductENSG00000162711 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
OLIG1GeneProductENSG00000184221 (Ensembl)
OLIG2GeneProductENSG00000205927 (Ensembl)
OSMGeneProductENSG00000099985 (Ensembl)
P2RY12GeneProductENSG00000169313 (Ensembl)
PDCD1GeneProductENSG00000188389 (Ensembl)
PDGFAGeneProduct5154 (Entrez Gene)
PDGFRAGeneProductENSG00000134853 (Ensembl)
PLP1GeneProductENSG00000123560 (Ensembl)
PTK2GeneProductENSG00000169398 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
ROS1GeneProductENSG00000047936 (Ensembl)
SEMA3FGeneProductENSG00000001617 (Ensembl)
SIRPAGeneProductENSG00000198053 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SOCS3GeneProductENSG00000184557 (Ensembl)
SOX9GeneProductENSG00000125398 (Ensembl)
SPP1GeneProductENSG00000118785 (Ensembl)
SSTR2GeneProductENSG00000180616 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT4GeneProductENSG00000138378 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TGFBR3GeneProductENSG00000069702 (Ensembl)
TGM2GeneProductENSG00000198959 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TMEM119GeneProductENSG00000183160 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TNFRSF1BGeneProductENSG00000028137 (Ensembl)
TRACGeneProductENSG00000277734 (Ensembl)
TRBC1GeneProductENSG00000211751 (Ensembl)
TRBC2GeneProductENSG00000211772 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
glutamateMetaboliteCHEBI:14321 (ChEBI)
nitric oxideMetaboliteCHEBI:16480 (ChEBI)
serotonineMetaboliteCHEBI:28790 (ChEBI)

Annotated Interactions

No annotated interactions

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