RNA-polymerase II transcription: the preinitiation complex (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none TAF3TAF9TAF7TAF4TAF11TAF5TAF10TAF12TAF6TAF13TAF1TAF 13-subunitTAF8TAF2MED24MED14MED28MED6MED31MED4MED11MED15MED19MED21MED25MED9MED20MED8MED17MED1MED10MED26MED16MED22MED30MED29MED7MED18Mediator 26-subunitMED23MED27LegendBinding of complexes/subunitsNELF complexNELFCDNELFBNELFENELFACDK8-Mediator complexMED13CDK8CCNCMED12Preinitiation complex coreRNA-polymerase IIGTF2F1GTF2E2GTF2BGTF2A1TBPRNA-polymerase II Transcription ElongationTFIID ComplexTHRAPOLR2MTranscription factorTranscription factors (TF)Epilepsy or seizure causing genesPOLR2EPOLR2HPOLR2BPOLR2APOLR2JPOLR2CPOLR2FPOLR2KPOLR2IPOLR2GPOLR2LRNA-polymerase IIPOLR2DELK1PC-terminus RNA-polymerase IITAF 13-subunitCTDP1Mediator 26-subunitERCC3Promoter openingC-terminus RNA-polymerase IIPromoter escapePEukaryotic transcription initiationCatalysisInhibition of bindingInhibition of pathwayActivation of pathwayBinding of single genesConversionMember of complexName: RNA-polymerase II transcription: the preinitiation complexOrganism: Homo sapiens


Description

RNA Polymerase II transcription: the preinitiation complex.

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
139711view10:24, 1 July 2025Jmlohmannadded pathway reference and legend TFIID complex
139627view10:05, 24 June 2025Jmlohmannensured RNA-polymerase II was written the same everywhere.
139509view09:43, 20 June 2025JmlohmannAdded reference
139465view03:39, 19 June 2025EgonwModified description
139450view09:33, 18 June 2025JmlohmannAdded legend
139445view14:49, 17 June 2025KhanspersOntology Term : 'regulatory pathway' added !
139444view14:49, 17 June 2025KhanspersOntology Term : 'RNA polymerase II transcription pathway' added !
139443view14:47, 17 June 2025KhanspersOntology Term : 'PW:0002656' removed !
139442view14:47, 17 June 2025KhanspersOntology Term : 'DNA biosynthetic pathway' added !
139439view10:11, 17 June 2025Jmlohmannadded genes for RNA polymerase 2 complex and CDK-8 interaction
139404view09:54, 15 June 2025EgonwMade a pathway clickable
139403view09:53, 15 June 2025EgonwType a gene as GeneProduct
139351view19:24, 3 June 2025JmlohmannAdded transcription initation pathway + Wikipathway identifier
139350view19:16, 3 June 2025Jmlohmannchanged 2 into II
139349view19:15, 3 June 2025JmlohmannNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
C-terminus RNA-polymerase IIComplex
CCNCGeneProductENSG00000112237 (Ensembl)
CDK8GeneProductENSG00000132964 (Ensembl)
CTDP1GeneProductENSG00000060069 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
ERCC3GeneProductENSG00000163161 (Ensembl)
Epilepsy or seizure causing genes
Eukaryotic transcription initiationPathwayWP405 (WikiPathways)
GTF2A1GeneProductENSG00000165417 (Ensembl)
GTF2BGeneProductENSG00000137947 (Ensembl)
GTF2E2GeneProductENSG00000197265 (Ensembl)
GTF2F1GeneProductENSG00000125651 (Ensembl)
MED10GeneProductENSG00000133398 (Ensembl)
MED11GeneProductENSG00000161920 (Ensembl)
MED12GeneProductENSG00000184634 (Ensembl)
MED13GeneProductENSG00000108510 (Ensembl)
MED14GeneProductENSG00000180182 (Ensembl)
MED15GeneProductENSG00000099917 (Ensembl)
MED16GeneProductENSG00000175221 (Ensembl)
MED17GeneProductENSG00000042429 (Ensembl)
MED18GeneProductENSG00000130772 (Ensembl)
MED19GeneProductENSG00000156603 (Ensembl)
MED1GeneProductENSG00000125686 (Ensembl)
MED20GeneProductENSG00000124641 (Ensembl)
MED21GeneProductENSG00000152944 (Ensembl)
MED22GeneProductENSG00000148297 (Ensembl)
MED23GeneProductENSG00000112282 (Ensembl)
MED24GeneProductENSG00000008838 (Ensembl)
MED25GeneProductENSG00000104973 (Ensembl)
MED26GeneProductENSG00000105085 (Ensembl)
MED27GeneProductENSG00000160563 (Ensembl)
MED28GeneProductENSG00000118579 (Ensembl)
MED29GeneProductENSG00000063322 (Ensembl)
MED30GeneProductENSG00000164758 (Ensembl)
MED31GeneProductENSG00000108590 (Ensembl)
MED4GeneProductENSG00000136146 (Ensembl)
MED6GeneProductENSG00000133997 (Ensembl)
MED7GeneProductENSG00000155868 (Ensembl)
MED8GeneProductENSG00000159479 (Ensembl)
MED9GeneProductENSG00000141026 (Ensembl)
Mediator 26-subunit
NELFAGeneProductENSG00000185049 (Ensembl)
NELFBGeneProductENSG00000188986 (Ensembl)
NELFCDGeneProductENSG00000101158 (Ensembl)
NELFEGeneProductENSG00000204356 (Ensembl)
POLR2AGeneProductENSG00000181222 (Ensembl)
POLR2BGeneProductENSG00000047315 (Ensembl)
POLR2CGeneProductENSG00000102978 (Ensembl)
POLR2DGeneProductENSG00000144231 (Ensembl)
POLR2EGeneProductPOLR2E (HGNC)
POLR2FGeneProductENSG00000100142 (Ensembl)
POLR2GGeneProductENSG00000168002 (Ensembl)
POLR2HProteinC9JJJ9 (Uniprot-TrEMBL)
POLR2IGeneProductENSG00000105258 (Ensembl)
POLR2JGeneProductENSG00000005075 (Ensembl)
POLR2KGeneProductENSG00000147669 (Ensembl)
POLR2LGeneProductENSG00000177700 (Ensembl)
POLR2MGeneProductENSG00000255529 (Ensembl)
Promoter escapePathway
Promoter openingPathway
RNA-polymerase IIComplex
RNA-polymerase II Transcription ElongationPathwayR-HSA-75955 (Reactome)
TAF 13-subunit
TAF10GeneProductENSG00000166337 (Ensembl)
TAF11GeneProductENSG00000064995 (Ensembl)
TAF12GeneProductENSG00000120656 (Ensembl)
TAF13GeneProductENSG00000197780 (Ensembl)
TAF1GeneProductENSG00000147133 (Ensembl)
TAF2GeneProductENSG00000064313 (Ensembl)
TAF3GeneProductENSG00000165632 (Ensembl)
TAF4GeneProductENSG00000130699 (Ensembl)
TAF5GeneProductENSG00000148835 (Ensembl)
TAF6GeneProductENSG00000106290 (Ensembl)
TAF7GeneProductENSG00000178913 (Ensembl)
TAF8GeneProductENSG00000137413 (Ensembl)
TAF9GeneProductENSG00000273841 (Ensembl)
TBPGeneProductENSG00000112592 (Ensembl)
TFIID ComplexComplex
THRAGeneProductENSG00000126351 (Ensembl)
Transcription factor
Transcription factors (TF)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5563"
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