Monoamine GPCRs (Mus musculus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Gs PathwayGi/Go PathwayGs PathwayHistamineReceptorsAdrenergicReceptorsMuscarinicAcetylcholine ReceptorsGq/G11 PathwayDopamineReceptorsSerotoninReceptorsSerotoninHistamineDopamineDrd3Drd5Drd4Drd2Drd1aAcetylcholineMuscarineChrm3Chrm2Chrm1Chrm4Chrm5EpinephrineNorepinephrineHrh1Hrh2Adra2cAdra1aAdrb3Adra1bAdra2aAdrb1Adra2bAdra1dAdrb2Htr4Htr5bHtr6Htr1dHtr7Htr2aHtr1fHtr5aHtr2cHtr2bHtr1aHtr1bName: Monoamine GPCRsLast Modified: 5/16/2012Organism: Mus musculus


Description

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [Wikipedia](https://en.wikipedia.org/wiki/G_protein–coupled_receptor) Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. [Monoamine neurotransmitters](https://en.wikipedia.org/wiki/Monoamine_neurotransmitter)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP58(r20799) with a 86% conversion rate.

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Quality Tags

Image:NeedsRef.pngAdd references
Image:NonTypical.pngAnnotated lists
Image:Curated.pngApproved version
Homology Converted

Ontology Terms

Pathway Ontology : regulatory pathway
 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
137263
Approved
view13:44, 1 March 2025EgonwModified description
106904view13:37, 17 September 2019MaintBotHMDB identifier normalization
96091view19:09, 15 February 2018KhanspersModified description
72043view13:59, 24 October 2013Mkutmonfixed unconnected lines
69197view18:23, 8 July 2013MaintBotUpdated to 2013 gpml schema
67490view11:08, 26 June 2013DdiglesOntology Term : 'G protein mediated signaling pathway' added !
60231view20:15, 14 March 2013EgonwReplaced PubChem-substance with PubChem-compound.
55122view17:45, 12 December 2012SravanthisinhaReverted to version '05:32, 17 May 2012' by Sravanthisinha
55121view17:43, 12 December 2012ApplecoolModified description
55120view17:40, 12 December 2012ApplecoolModified description
48232view05:32, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41388view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
34427view23:22, 9 December 2009MaintBotAutomatic update of empty xrefs
32720view23:42, 2 September 2009MaintBotadded xrefs
32467view17:29, 15 August 2009MaintBotFixed text labels
32153view14:02, 14 August 2009MaintBotFixed group labels
31478view21:23, 13 August 2009MaintBotFixed text labels
30908view00:26, 30 July 2009MaintBotConverted from Homo sapiens
21880view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Monoamine GPCRs]] moved to [[Pathway:WP570]]: Moved to stable identifier
8268view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Monoamine GPCRs]] moved to [[Pathway:Mus musculus:Monoamine GPCRs]]: Renaming species
7754view16:15, 18 December 2007MaintBotfixed category names
7432view12:42, 4 November 2007MaintBotAdded categories to GPML
19516view22:19, 22 May 2007J.S.Fonggpml file for [[Mouse:Monoamine_GPCRs]]
6477view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:Monoamine_GPCRs]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
Acetylcholine MetaboliteHMDB0000895 (HMDB)
Adra1aGeneProduct11549 (Entrez Gene)
Adra1bGeneProduct11548 (Entrez Gene)
Adra1dGeneProduct11550 (Entrez Gene)
Adra2aGeneProduct11551 (Entrez Gene)
Adra2bGeneProduct11552 (Entrez Gene)
Adra2cGeneProduct11553 (Entrez Gene)
Adrb1GeneProduct11554 (Entrez Gene)
Adrb2GeneProduct11555 (Entrez Gene)
Adrb3GeneProduct11556 (Entrez Gene)
Chrm1GeneProduct12669 (Entrez Gene)
Chrm2GeneProduct243764 (Entrez Gene)
Chrm3GeneProduct12671 (Entrez Gene)
Chrm4GeneProduct12672 (Entrez Gene)
Chrm5GeneProduct213788 (Entrez Gene)
DopamineMetaboliteHMDB0000073 (HMDB)
Drd1aGeneProduct13488 (Entrez Gene)
Drd2GeneProduct13489 (Entrez Gene)
Drd3GeneProduct13490 (Entrez Gene)
Drd4GeneProduct13491 (Entrez Gene)
Drd5GeneProduct13492 (Entrez Gene)
EpinephrineMetaboliteHMDB0000068 (HMDB)
HistamineMetaboliteHMDB0000870 (HMDB)
Hrh1GeneProduct15465 (Entrez Gene)
Hrh2GeneProduct15466 (Entrez Gene)
Htr1aGeneProduct15550 (Entrez Gene)
Htr1bGeneProduct15551 (Entrez Gene)
Htr1dGeneProduct15552 (Entrez Gene)
Htr1fGeneProduct15557 (Entrez Gene)
Htr2aGeneProduct15558 (Entrez Gene)
Htr2bGeneProduct15559 (Entrez Gene)
Htr2cGeneProduct15560 (Entrez Gene)
Htr4GeneProduct15562 (Entrez Gene)
Htr5aGeneProduct15563 (Entrez Gene)
Htr5bGeneProduct15564 (Entrez Gene)
Htr6GeneProduct15565 (Entrez Gene)
Htr7GeneProduct15566 (Entrez Gene)
MuscarineMetabolite9308 (PubChem-compound)
NorepinephrineMetaboliteHMDB0000216 (HMDB)
SerotoninMetaboliteHMDB0000259 (HMDB)

Annotated Interactions

No annotated interactions
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