p53 pathway (Rattus norvegicus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cell cycleApoptosisCell cycleG1 arrestGenotoxic drugsROSTarget genesγ-irradiationDNAUVApoptoseStress signalsResponseCell cycle arrestDNA damageMitochondrionOncogen ActivationG2 arrestp53 negative feedbackHeat/cold shockNutrition deprivationIGF-1/mTOR pathwayInhibition ofNitric OxidesecretionExosome mediatedDNA repair anddamage preventionand metastasisInhibition of angiogenesisTSAP6Casp8PUMAMaspin14-3-3-σTsc2scotinCop-1PAG608p53Chek2RprmAdgrb1Apaf-1KAIPtenp21AtmB99IGF-BP3NoxaIGF-BP3p53R2BidGadd45aPERPPAIATRCytCCyclin GBaxCasp9Mdm-XIgf1SestrinsGadd45aWip1p14ARFFasp73Casp3Mdm2Siah1aSiahChek1PigsPIRH-2Mdm2Cyclin DCdk2Cdk4/6Cyclin ECdc2aCyclin BHypoxiaName: p53 pathwayOrganism: Rattus norvegicus


Description

p53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cycle and thus functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome," "the guardian angel gene," and the "master watchman," referring to its role in conserving stability by preventing genome mutation.

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : regulatory pathway
 

Bibliography

  1. Nelson DM, Bhaskaran V, Foster WR, Lehman-McKeeman LD; ''p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile.''; Toxicol Sci, 2006 PubMed Europe PMC Scholia
  2. Vazquez A, Bond EE, Levine AJ, Bond GL; ''The genetics of the p53 pathway, apoptosis and cancer therapy.''; Nat Rev Drug Discov, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128741
Approved
view04:53, 21 February 2024EweitzUpgrade disease node
89792view10:51, 6 October 2016MaintBotfix special character
83035view03:02, 18 November 2015Mkutmonfix outdated identifier
78065view13:43, 25 November 2014Mkutmonfixed p73 label
71835view19:40, 18 October 2013MaintBotremoved data source from nodes without identifier
70126view19:37, 12 July 2013MaintBotupdated to 2013 schema
67573view11:28, 26 June 2013DdiglesOntology Term : 'p53 signaling pathway' added !
58969view18:41, 21 February 2013MaintBotUpdated Ensembl data source
41760view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
33397view14:46, 30 November 2009MaintBotRemoved group label
29760view18:59, 2 June 2009KhanspersModified categories
28752view14:19, 2 March 2009MartijnVanIerselMore general title
28551view17:15, 11 February 2009Kevinhermans1987Specify description
28549view17:11, 11 February 2009Kevinhermans1987Periodical save, work in progress
28548view17:08, 11 February 2009Kevinhermans1987Specify description
28524view14:20, 11 February 2009Kevinhermans1987Finished
28522view14:17, 11 February 2009Kevinhermans1987Modified description
28515view14:05, 11 February 2009Kevinhermans1987Specify description
28510view14:00, 11 February 2009Kevinhermans1987Specify description
28508view13:56, 11 February 2009Kevinhermans1987Periodical save, work in progress
28503view13:53, 11 February 2009Kevinhermans1987Specify description
28499view13:50, 11 February 2009Kevinhermans1987Specify description
28497view13:49, 11 February 2009Kevinhermans1987Specify description
28494view13:46, 11 February 2009Kevinhermans1987Periodical save, work in progress
28490view13:40, 11 February 2009Kevinhermans1987Specify description
28487view13:36, 11 February 2009Kevinhermans1987Periodical save, work in progress
28482view13:27, 11 February 2009Kevinhermans1987Specify description
28481view13:25, 11 February 2009Kevinhermans1987Periodical save, work in progress
28479view13:24, 11 February 2009Kevinhermans1987Specify description
28470view13:15, 11 February 2009Kevinhermans1987Periodical save, work in progress
28465view13:09, 11 February 2009Kevinhermans1987Specify description
28460view13:05, 11 February 2009Kevinhermans1987Periodical save, work in progress
28457view13:02, 11 February 2009Kevinhermans1987Specify description
28454view12:55, 11 February 2009Kevinhermans1987Periodical save, work in progress
28450view12:50, 11 February 2009Kevinhermans1987Specify description
28448view12:49, 11 February 2009Kevinhermans1987Specify description
28445view12:48, 11 February 2009Kevinhermans1987Specify description
28442view12:45, 11 February 2009Kevinhermans1987Periodical save, work in progress
28439view12:42, 11 February 2009Kevinhermans1987Specify description
28435view12:39, 11 February 2009Kevinhermans1987Specify description
28432view12:35, 11 February 2009Kevinhermans1987Periodical save, work in progress
28427view12:29, 11 February 2009Kevinhermans1987Specify description
28423view12:23, 11 February 2009Kevinhermans1987Specify description
28421view12:21, 11 February 2009Kevinhermans1987Specify description
28417view12:16, 11 February 2009Kevinhermans1987Periodical save, work in progress
28409view12:06, 11 February 2009Kevinhermans1987Periodical save, work in progress
28405view12:02, 11 February 2009Kevinhermans1987Specify description
28401view11:56, 11 February 2009Kevinhermans1987Periodical save, work in progress
28400view11:55, 11 February 2009Kevinhermans1987Specify description
28394view11:45, 11 February 2009Kevinhermans1987New pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
14-3-3-σGeneProduct298795 (Entrez Gene)
ATRGeneProduct300944 (Entrez Gene)
Adgrb1GeneProductENSRNOG00000029450 (Ensembl)
Apaf-1GeneProduct78963 (Entrez Gene)
AtmGeneProduct300711 (Entrez Gene)
B99GeneProduct300126 (Entrez Gene)
BaxGeneProduct24887 (Entrez Gene)
BidGeneProduct64625 (Entrez Gene)
Casp3GeneProduct25402 (Entrez Gene)
Casp8GeneProduct64044 (Entrez Gene)
Casp9GeneProduct58918 (Entrez Gene)
Cdc2aGeneProduct54237 (Entrez Gene)
Cdk2GeneProduct362817 (Entrez Gene)
Cdk4/6GeneProduct114483 (Entrez Gene)
Chek1GeneProduct140583 (Entrez Gene)
Chek2GeneProduct114212 (Entrez Gene)
Cop-1GeneProduct
Cyclin BGeneProduct25203 (Entrez Gene)
Cyclin DGeneProduct
Cyclin EGeneProduct25729 (Entrez Gene)
Cyclin GGeneProduct25405 (Entrez Gene)
CytCGeneProduct25309 (Entrez Gene)
FasGeneProduct246097 (Entrez Gene)
Gadd45aGeneProduct25112 (Entrez Gene)
HypoxiaQ105688 (Wikidata)
IGF-BP3GeneProduct24484 (Entrez Gene)
Igf1GeneProduct24482 (Entrez Gene)
KAIGeneProduct83628 (Entrez Gene)
MaspinGeneProduct116589 (Entrez Gene)
Mdm-XGeneProductENSRNOG00000009696 (Ensembl)
Mdm2GeneProduct314856 (Entrez Gene)
NoxaGeneProduct492821 (Entrez Gene)
PAG608GeneProduct64394 (Entrez Gene)
PAIGeneProduct24617 (Entrez Gene)
PERPGeneProduct292949 (Entrez Gene)
PIRH-2GeneProduct289508 (Entrez Gene)
PUMAGeneProduct
PigsGeneProduct300514 (Entrez Gene)
PtenGeneProduct50557 (Entrez Gene)
RprmGeneProduct680110 (Entrez Gene)
SestrinsGeneProductENSRNOG00000000302 (Ensembl)
SiahGeneProduct140941 (Entrez Gene)
Siah1aGeneProduct140941 (Entrez Gene)
TSAP6GeneProduct
Tsc2GeneProduct24855 (Entrez Gene)
Wip1GeneProduct287585 (Entrez Gene)
p14ARFGeneProduct25163 (Entrez Gene)
p21GeneProduct114851 (Entrez Gene)
p53GeneProductENSRNOG00000010756 (Ensembl)
p53R2GeneProductENSRNOG00000025454 (Ensembl)
p73GeneProduct362675 (Entrez Gene)
scotinGeneProduct301013 (Entrez Gene)

Annotated Interactions

No annotated interactions

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