Blood clotting cascade (Gallus gallus)

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1 Factor VIIIaFactor XaFactor VaThrombinTissue FactorFactor XIIIaIntrinsic PathwayFactor XIIaExtrinsic Pathway PlasminFactor VIIaFibrin MonomerFibrin PolymerThrombolysisFactor IXaFibrin Split Products+Factor XIaTissue InjuryF8SERPINF2F13BVWFF2PLGF10F12FibrinF11F9PLATSERPINE1F10F7PLAUF8A1FGAFGBProthrombinase ComplexFGGF5SERPINB2


Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis). Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP272(r30179) with a 73% conversion rate.

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Ontology Terms



  1. Luchtman-Jones L, Broze GJ Jr; ''The current status of coagulation.''; Ann Med, 1995 PubMed Europe PMC Scholia


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117189view10:31, 18 May 2021EweitzModified title
72063view17:29, 24 October 2013MaintBotremoved data source from nodes without identifier
68812view17:15, 8 July 2013MaintBotUpdated to 2013 gpml schema
67095view10:05, 26 June 2013Christine ChichesterOntology Term : 'coagulation cascade pathway' added !
62669view18:31, 1 May 2013MaintBotUpdated Ensembl and UniProt data source
40946view22:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35086view12:31, 11 February 2010Thomasfixed group positions, removed incorrect line
35082view12:25, 11 February 2010Thomasadded literature, fixed lines
35071view12:03, 11 February 2010ThomasModified description
33874view17:51, 9 December 2009MaintBotAutomatic update of empty xrefs
33457view15:01, 30 November 2009MaintBotRemoved group label
30344view20:50, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
F10GeneProduct395876 (Entrez Gene)
F11GeneProduct422723 (Entrez Gene)
F13BGeneProduct424355 (Entrez Gene)
F2GeneProduct395306 (Entrez Gene)
F5GeneProduct374052 (Entrez Gene)
F7GeneProduct395086 (Entrez Gene)
F8GeneProduct422199 (Entrez Gene)
F9GeneProduct374258 (Entrez Gene)
FGAGeneProduct396307 (Entrez Gene)
FGBGeneProduct373926 (Entrez Gene)
FGGGeneProduct395837 (Entrez Gene)
PLATGeneProduct426791 (Entrez Gene)
PLAUGeneProduct396424 (Entrez Gene)
PLGGeneProduct421580 (Entrez Gene)
Prothrombinase ComplexGeneProduct
SERPINB2GeneProduct420896 (Entrez Gene)
SERPINF2GeneProduct417561 (Entrez Gene)
VWFGeneProduct419031 (Entrez Gene)

Annotated Interactions

No annotated interactions
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