G1 to S cell cycle control (Gallus gallus)

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1bCyclin EspG2 Phase-M phaseCyclin DsG1/S Cell CycleuupE2fcakeDNA replicationG1 CyclinDependant CyclasesCyclinDTTTCC/GCGCpDegradationG1/S transition CyclinDependent Kinasesphosphorylation of proteinsinvolved in G1/S transitionuorigin recognition complexpbG1 PhaseRbDNA polymerasesedp1pCheckpointinactivepCell cycle DNA replication genesG1/S transition PhaseCREBL1CDKN1CPRIM2TP53E2F6MYT1CCNA1RPA1E2F3CREB3L3RB1CDKN2DCDKN2BCDK6CDK4MCM4WEE1POLEPRIM1TFDP1RPA3MCM3CCNE1CDK2ORC6CCNB1CCNE2CDK1MCM5CDC45GADD45ATFDP1ORC3TFDP2CDKCCND2CDK7CDKN2AE2F1RBL1RB1CCNE1POLA2MNAT1CDC25AE2F2MCM7CDK6CCNHE2F5PCNACDKN1AMYCCCNG2CCND1CREB3L4TP53CDK7RB1CREB3CDKN1BMCM6CREB3L1CDKORC5CDK2E2fMCM2ORC4CCND3E2F4ORC2CCNE1MDM2RPA2POLE2CDKN2CATMORC1CDK4CREB1E2fCdKCyclinDCdK


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP45 (r95145) with a 81.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95750view13:54, 19 January 2018MkutmonHomology conversion update
74229view16:23, 8 April 2014EgonwRemoved a data source where no ID was given.
68801view17:14, 8 July 2013MaintBotUpdated to 2013 gpml schema
67271view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
47792view16:31, 6 April 2012Khanspersupdated xrefs
40934view22:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
35830view22:15, 17 February 2010KhanspersAdded lit ref
35829view22:14, 17 February 2010KhanspersModified description
33865view17:48, 9 December 2009MaintBotAutomatic update of empty xrefs
33510view15:16, 30 November 2009MaintBotRemoved group label
31551view21:52, 13 August 2009MaintBotFixed text labels
30409view21:12, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATMGeneProductENSGALG00000017159 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:472
CCNA1GeneProductENSGALG00000017052 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8900
CCNB1GeneProductNo homologues found for original id L:891
CCND1GeneProductENSGALG00000007555 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:595
CCND2GeneProductENSGALG00000017283 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:894
CCND3GeneProductENSGALG00000003485 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:896
CCNE1GeneProductENSGALG00000004494 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:898
CCNE2GeneProductENSGALG00000040794 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9134
CCNG2GeneProductENSGALG00000010347 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:901
CCNHGeneProductENSGALG00000015641 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:902
CDC25AGeneProductENSGALG00000038469 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:993
CDC45GeneProductENSGALG00000001616 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8318
CDKGeneProduct
CDK1GeneProductENSGALG00000003085 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:983
CDK2GeneProductENSGALG00000032699 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1017
CDK4GeneProductNo homologues found for original id L:1019
CDK6GeneProductENSGALG00000009476 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1021
CDK7GeneProductENSGALG00000014790 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1022
CDKN1AGeneProductENSGALG00000028318 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1026
CDKN1BGeneProductENSGALG00000022980 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1027
CDKN1CGeneProductNo homologues found for original id L:1028
CDKN2AGeneProductENSGALG00000026137 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1029
CDKN2BGeneProductENSGALG00000026137 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1030
CDKN2CGeneProductENSGALG00000010537 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1031
CDKN2DGeneProductNo homologues found for original id L:1032
CREB1GeneProductENSGALG00000041244 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1385
CREB3GeneProductENSGALG00000002523 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10488
CREB3L1GeneProductENSGALG00000008393 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:90993
CREB3L3GeneProductENSGALG00000001252 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:84699
CREB3L4GeneProductNo homologues found for original id L:148327
CREBL1GeneProductNo homologues found for original id L:1388
E2F1GeneProductENSGALG00000003045 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1869
E2F2GeneProductNo homologues found for original id L:1870
E2F3GeneProductENSGALG00000012680 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1871
E2F4GeneProductENSGALG00000001722 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1874
E2F5GeneProductENSGALG00000038915 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1875
E2F6GeneProductENSGALG00000016454 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1876
E2fGeneProduct
GADD45AGeneProductENSGALG00000025977 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1647
MCM2GeneProductENSGALG00000006037 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4171
MCM3GeneProductENSGALG00000016676 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4172
MCM4GeneProductENSGALG00000012915 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4173
MCM5GeneProductENSGALG00000012546 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4174
MCM6GeneProductENSGALG00000012348 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4175
MCM7GeneProductNo homologues found for original id L:4176
MDM2GeneProductENSGALG00000009942 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4193
MNAT1GeneProductENSGALG00000011910 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4331
MYCGeneProductENSGALG00000033631 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4609
MYT1GeneProductENSGALG00000005932 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4661
ORC1GeneProductENSGALG00000010623 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4998
ORC2GeneProductENSGALG00000008234 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4999
ORC3GeneProductENSGALG00000015800 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:23595
ORC4GeneProductENSGALG00000012448 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5000
ORC5GeneProductENSGALG00000008175 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5001
ORC6GeneProductENSGALG00000004342 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:23594
PCNAGeneProductENSGALG00000029292 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5111
POLA2GeneProductENSGALG00000030099 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:23649
POLE2GeneProductENSGALG00000012237 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5427
POLEGeneProductENSGALG00000039384 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5426
PRIM1GeneProductENSGALG00000041973 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5557
PRIM2GeneProductENSGALG00000016278 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5558
RB1GeneProductENSGALG00000016997 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5925
RBL1GeneProductENSGALG00000001332 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5933
RPA1GeneProductENSGALG00000003072 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6117
RPA2GeneProductENSGALG00000000734 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6118
RPA3GeneProductENSGALG00000010700 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6119
TFDP1GeneProductENSGALG00000016823 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7027
TFDP2GeneProductENSGALG00000025759 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7029
TP53GeneProductNo homologues found for original id L:7157
WEE1GeneProductENSGALG00000005769 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7465

Annotated Interactions

No annotated interactions
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