Eicosanoid synthesis (Pan troglodytes)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cell Membrane15-Hydroperoxy Eicosatetraenoic Acid6-Keto-Prostaglandin F2-alpha12-Hydroperoxy Eicosatetraenoic AcidThromboxane A3Prostaglandin E25-HETEPTGDS5-HPETEProstaglandin H2DPEP1PTGISLeukotriene D4TBXAS1Peroxidase?Thromboxane B2Prostaglandin I2Prostaglandin D2PGE2 9-ketoreducGGT1ALOX15BLeukotriene A4Prostaglandin F2aLeukotriene C4Leukotriene E4LTA4HLTC4S12-HETEPeroxidase?15-HETEThromboxane A2Arachidonic acidPeroxidase?Leukotriene B4PGD2 11-ketoreducPTGES2PTGESPTGS1PTGS2ALOX5APALOX5PLA2G2APLA2G6PLA2G6PNPLA8ALOX15ALOX15ALOX12ALOX5ALOX5APName: Eicosanoid synthesisLast Modified: 10/17/2013Organism: Pan troglodytes


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [Wikipedia](https://en.wikipedia.org/wiki/Eicosanoid)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 64% conversion rate.

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Quality Tags

Image:MissingXref.pngAnnotate nodes
Image:Curated.pngApproved version
Homology Converted

Ontology Terms

Pathway Ontology : DNA repair pathway miRNA pathway
 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
136930
Approved
view19:36, 26 February 2025KhanspersModified description
117389view10:32, 21 May 2021EweitzModified title
106916view13:38, 17 September 2019MaintBotHMDB identifier normalization
89538view11:07, 16 September 2016Mkutmonontology tag fix
89480view13:39, 15 September 2016Mkutmonremove space from ontology term id
78368view10:19, 7 January 2015MaintBotadded missing graphIds
71678view19:41, 17 October 2013MaintBotAutomated update of data sources
69276view18:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
67187view10:18, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62743view03:35, 2 May 2013MaintBotUpdated UniProt data source
41585view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
35482view12:16, 12 February 2010Thomasadded literature
35478view12:14, 12 February 2010ThomasModified description
34314view22:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33524view09:32, 1 December 2009MaintBotRemoved group label
30423view21:16, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
12-HETEMetabolite
15-HETEMetabolite
5-HETEMetabolite
5-HPETEMetaboliteHMDB0001193 (HMDB)
ALOX12GeneProduct455242 (Entrez Gene)
ALOX15GeneProduct748294 (Entrez Gene)
ALOX15BGeneProduct455104 (Entrez Gene)
ALOX5GeneProduct450428 (Entrez Gene)
ALOX5APGeneProduct452520 (Entrez Gene)
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
DPEP1GeneProduct
GGT1GeneProduct470168 (Entrez Gene)
LTA4HGeneProduct452145 (Entrez Gene)
LTC4SGeneProduct739986 (Entrez Gene)
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
PLA2G2AGeneProduct456587 (Entrez Gene)
PLA2G6GeneProduct
PNPLA8GeneProduct472484 (Entrez Gene)
PTGDSGeneProduct749402 (Entrez Gene)
PTGES2GeneProduct464763 (Entrez Gene)
PTGESGeneProduct473071 (Entrez Gene)
PTGISGeneProduct458323 (Entrez Gene)
PTGS1GeneProduct464713 (Entrez Gene)
PTGS2GeneProduct469616 (Entrez Gene)
Peroxidase?GeneProduct
Prostaglandin D2MetaboliteHMDB0001403 (HMDB)
Prostaglandin F2aMetaboliteHMDB0001139 (HMDB)
Prostaglandin H2MetaboliteHMDB0001381 (HMDB)
Prostaglandin I2MetaboliteHMDB0001335 (HMDB)
TBXAS1GeneProduct463774 (Entrez Gene)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)

Annotated Interactions

No annotated interactions
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