FAS pathway and stress induction of HSP regulation (Pan troglodytes)

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13x-PMitochondria PathwayCell SurvivalNucleusNFK-B PathwayActivateExtracellularProteasomeStress Induction of HSP regulationSelf-activation3x-PFAS PathwayCutStressCytoplasmNecrosisDNA presentation3x-PInhibitionApoptosomeROSHSPB1CASP8PhosphateHSPB1FASPhosphateLMNAPAK2PhosphateCASP10MAPK8TNFPRKDCSPTAN1MAP2K4DFFBPhosphateDFFABCL2IL1ALMNB2HSPB1PAK1FAP1RB1PARP1MAPKAPK3FAF1DAXXFASLGHSPB1actinPhosphateDFFBARHGDIBJUNFAF1CASP3MAP3K7CASP3MAPKAPK2APAF1CYCSCASP8GlutathioneApoptosisMAP3K1CeramideFADDRIPK2CASP6LMNB1CFLARHSPB1HSPB1CASP9PhosphateHSPB1PhosphateAPAF1PhosphateCASP7DAXXHSPB1


Description

This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: BioCarta.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP314(r45253) with a 88% conversion rate.

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Ontology Terms

 

Bibliography

  1. Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117066view14:25, 16 May 2021EweitzModified title
111163view09:26, 21 July 2020EgonwMade another pathway clickable
106930view13:39, 17 September 2019MaintBotHMDB identifier normalization
69227view18:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
67226view10:23, 26 June 2013Christine ChichesterOntology Term : 'FasL mediated signaling pathway' added !
48165view20:24, 9 May 2012MaintBotUpdating from human to fix xref
41530view01:57, 2 March 2011MaintBotRemoved redundant pathway information and comments
38246view21:24, 27 August 2010KhanspersRemoved receptor and protein complex graphics
35557view15:00, 12 February 2010ThomasModified description
35554view14:58, 12 February 2010Thomasadded literature
34266view21:52, 9 December 2009MaintBotAutomatic update of empty xrefs
33562view09:44, 1 December 2009MaintBotRemoved group label
31589view22:04, 13 August 2009MaintBotFixed text labels
30471view21:32, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APAF1GeneProduct452153 (Entrez Gene)
ARHGDIBGeneProduct742002 (Entrez Gene) Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
ApoptosisPathwayWP254 (WikiPathways)
BCL2GeneProduct738409 (Entrez Gene)
CASP10GeneProduct
CASP3GeneProduct461669 (Entrez Gene)
CASP6GeneProduct736606 (Entrez Gene)
CASP7GeneProduct450745 (Entrez Gene)
CASP8GeneProduct746477 (Entrez Gene)
CASP9GeneProduct456457 (Entrez Gene)
CFLARGeneProduct459872 (Entrez Gene)
CYCSGeneProduct
CeramideMetabolite104404-17-3 (CAS)
DAXXGeneProduct462613 (Entrez Gene)
DFFAGeneProduct457928 (Entrez Gene)
DFFBGeneProduct744932 (Entrez Gene)
FADDGeneProduct451389 (Entrez Gene)
FAF1GeneProduct456846 (Entrez Gene)
FAP1GeneProduct
FASGeneProduct738331 (Entrez Gene)
FASLGGeneProduct469584 (Entrez Gene)
GlutathioneMetaboliteHMDB0000125 (HMDB)
HSPB1GeneProduct463488 (Entrez Gene)
IL1AGeneProduct470485 (Entrez Gene)
JUNGeneProduct456893 (Entrez Gene)
LMNAGeneProduct457385 (Entrez Gene)
LMNB1GeneProduct462035 (Entrez Gene)
LMNB2GeneProduct
MAP2K4GeneProduct455065 (Entrez Gene)
MAP3K1GeneProduct471543 (Entrez Gene)
MAP3K7GeneProduct462888 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MAPKAPK2GeneProduct744091 (Entrez Gene)
MAPKAPK3GeneProduct460400 (Entrez Gene)
PAK1GeneProduct451439 (Entrez Gene)
PAK2GeneProduct460965 (Entrez Gene)
PARP1GeneProduct
PRKDCGeneProduct464165 (Entrez Gene)
PhosphateMetaboliteHMDB0001429 (HMDB)
RB1GeneProduct452715 (Entrez Gene)
RIPK2GeneProduct464277 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 2
SPTAN1GeneProduct464771 (Entrez Gene) Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
TNFGeneProduct494186 (Entrez Gene)
actinGeneProduct

Annotated Interactions

No annotated interactions
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