Nuclear receptors (Pan troglodytes)

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1Androgen ReceptorNuclear receptor TLXOxysterols ReceptorOrphan NuclearOrphan ReceptorNR5 SUPERFAMILYPeroxisome ProliferatorOrphan Nuclear ReceptorThyroid ReceptorNR2 SUPERFAMILYNR3 SUPERFAMILYVitamin D3 ReceptorActivated ReceptorGlucocorticoid ReceptorSteroid Hormone ReceptorOrphan ReceptorSteroidogenic ReceptorCoup Transcription FactorRetinoic Acid Receptor RXRProgesterone ReceptorNR1 SUPERFAMILYEstrogen ReceptorRetinoic Acid ReceptorNuclear Receptor RORNR4 SUPERFAMILYHepatocyte Nuclear FactorNR0 SUPERFAMILYReceptorARPPARANR4A1RORAVDRNR1H2RARATHRANR2F6NR1I3ESR1HNF4ANR4A2ESRRAPPARGNR1D2NR2C2RXRARARGESR2NR1H3THRBRXRBESRRBRARBRORCRXRGNR2F1NR5A1NR3C1THRBPGRRARGNR2F2NR1I2NR5A2PPARGROR1PPARDNR2E1NR0B1


Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia (wikipedia:Nuclear_receptor)


This pathway was inferred from Homo sapiens pathway WP170(r21037) with a 85% conversion rate.

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  1. Nagy L, Schule R, Gronemeyer H; ''Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.''; EMBO Rep, 2006 PubMed Europe PMC Scholia


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117408view10:39, 21 May 2021EweitzModified title
89866view12:35, 6 October 2016MkutmonModified description
78373view10:22, 7 January 2015MaintBotadded missing graphIds
69981view21:20, 11 July 2013MaintBot
69980view21:20, 11 July 2013MaintBotupdated to 2013 schema
67535view11:22, 26 June 2013DdiglesOntology Term : 'transcription factor mediated signaling pathway' added !
41524view01:57, 2 March 2011MaintBotRemoved redundant pathway information and comments
35771view00:12, 13 February 2010AlexanderPico
34262view21:51, 9 December 2009MaintBotAutomatic update of empty xrefs
33599view09:56, 1 December 2009MaintBotRemoved group label
30519view21:49, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ARGeneProduct747460 (Entrez Gene)
ESR1GeneProduct463079 (Entrez Gene)
ESR2GeneProduct452964 (Entrez Gene)
ESRRAGeneProduct466651 (Entrez Gene)
ESRRBGeneProduct453056 (Entrez Gene)
HNF4AGeneProduct458269 (Entrez Gene)
NR0B1GeneProduct450140 (Entrez Gene)
NR1D2GeneProduct460230 (Entrez Gene)
NR1H2GeneProduct456227 (Entrez Gene)
NR1H3GeneProduct466507 (Entrez Gene)
NR1I2GeneProduct745458 (Entrez Gene)
NR1I3GeneProduct458014 (Entrez Gene)
NR2C2GeneProduct460199 (Entrez Gene)
NR2E1GeneProduct472088 (Entrez Gene)
NR2F1GeneProduct461753 (Entrez Gene)
NR2F2GeneProduct467769 (Entrez Gene)
NR2F6GeneProduct748739 (Entrez Gene)
NR3C1GeneProduct471681 (Entrez Gene)
NR4A1GeneProduct451913 (Entrez Gene)
NR4A2GeneProduct459669 (Entrez Gene)
NR5A1GeneProduct464724 (Entrez Gene)
NR5A2GeneProduct469631 (Entrez Gene)
PGRGeneProduct451502 (Entrez Gene)
PPARAGeneProduct458910 (Entrez Gene)
PPARDGeneProduct463188 (Entrez Gene)
PPARGGeneProduct460178 (Entrez Gene)
RARAGeneProduct454647 (Entrez Gene)
RARBGeneProduct745516 (Entrez Gene)
RARGGeneProduct451935 (Entrez Gene)
ROR1GeneProduct456910 (Entrez Gene)
RORAGeneProduct747433 (Entrez Gene)
RORCGeneProduct457303 (Entrez Gene)
RXRAGeneProduct464834 (Entrez Gene)
RXRBGeneProduct462601 (Entrez Gene)
RXRGGeneProduct457476 (Entrez Gene)
THRBGeneProduct470771 (Entrez Gene)

Annotated Interactions

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