Apoptosis modulation by HSP70 (Pan troglodytes)

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TNF-alphaProteasomeNF-kBpathwayAPOPTOSISCELL SURVIVALMitochondriaActivationInhibitionDegradation ofIk alpha(activation of NFkB)InhibitionApoptosomeDegradation of proteinsInhibitionSTRESSFAS-LigandInhibitionRIPK1PDCD8HSPA1ACASP6FADDMAP3K1CASP8MAPK10NFKB1HSPA1ACASP7BIDFASHSPA1ACASP8FADDTNFRSF1AAPAF1CYCSCASP3CASP9CYCSCASP2


This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis. This pathway was originally adapted from rat. This pathway was inferred from Homo sapiens pathway WP384(r29910) with a 69% conversion rate.


GenMAPP notes 
References of HSP70 and inhibition of apoptosis:

1. Garrido C, Schmitt E, Cande C, Vahsen N, Parcellier A, Kroemer G. HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Cell Cycle. 2003 Nov-Dec;2(6):579-84. PMID: 14512773 [PubMed - in process]
2. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol. 2000 Oct;20(19):7146-59. PMID: 10982831 [PubMed - indexed for MEDLINE]
3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000 Aug;2(8):476-83. PMID: 10934467 [PubMed - indexed for MEDLINE]
4. Schett G, Steiner CW, Groger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J. 1999 May;13(8):833-42. PMID: 10224227 [PubMed - indexed for MEDLINE]
5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 1998 Oct 30;438(1-2):1-4. Review. PMID: 9821948 [PubMed - indexed for MEDLINE]
6. Jaattela M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.
EMBO J. 1998 Nov 2;17(21):6124-34. PMID: 9799222 [PubMed - indexed for MEDLINE]
7. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci P. The life span determinant p66Shc localizes to mitochondria where it associates with mtHsp70 and regulates trans-membrane potential. J Biol Chem. 2004 Apr 12 [Epub ahead of print]
PMID: 15078873 [PubMed - as supplied by publisher]
8. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene. 2003 Oct 2;22(43):6669-78.
PMID: 14555980 [PubMed - indexed for MEDLINE]

GenMAPP remarks 
Right click for info. Adapted from rat by GenMAPP
This pathway was inferred from Homo sapiens pathway WP384(r29910) with a 69% conversion rate.

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117082view14:50, 16 May 2021EweitzModified title
98542view20:51, 14 September 2018KhanspersModified description
87009view14:44, 15 July 2016MkutmonOntology Term : 'apoptotic cell death pathway' added !
72017view12:37, 24 October 2013MkutmonModified description
72016view12:36, 24 October 2013Mkutmonfixed unconnected lines
69317view18:44, 8 July 2013MaintBotUpdated to 2013 gpml schema
41627view02:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
34354view22:23, 9 December 2009MaintBotAutomatic update of empty xrefs
33612view10:00, 1 December 2009MaintBotRemoved group label
31625view22:20, 13 August 2009MaintBotFixed text labels
30532view21:53, 29 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
APAF1GeneProduct452153 (Entrez Gene)
BIDGeneProduct458635 (Entrez Gene)
CASP2GeneProduct463804 (Entrez Gene)
CASP3GeneProduct461669 (Entrez Gene)
CASP6GeneProduct736606 (Entrez Gene)
CASP7GeneProduct450745 (Entrez Gene)
CASP8GeneProduct746477 (Entrez Gene)
CASP9GeneProduct456457 (Entrez Gene)
CYCSGeneProduct744779 (Entrez Gene)
FADDGeneProduct451389 (Entrez Gene)
FASGeneProduct738331 (Entrez Gene)
MAP3K1GeneProduct471543 (Entrez Gene)
MAPK10GeneProduct461358 (Entrez Gene)
NFKB1GeneProduct461406 (Entrez Gene)
PDCD8GeneProductApoptosis Inducing Factor
RIPK1GeneProduct462397 (Entrez Gene)
TNFRSF1AGeneProduct466934 (Entrez Gene)

Annotated Interactions

No annotated interactions
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