Transcriptional activation by NRF2 (Bos taurus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ARECCAAT/XRENucleusPhase II enzymesGCLCHMOX1GSTA2NQO1GCLMS-PT-PNFE2L2S-PT-PNFE2L2MAFPRKCAMAPK8SulforaphaneAIMP2C/EBP-beta6-HITCKEAP1C/EBP-betaCaffeic acid phenethyl esterEPHB2PIK3CACurcuminNFE2L2KEAP1SLC7A11Name: Transcriptional activation by NRF2License: CC BY 2.0Last Modified: 5/16/2012Organism: Bos taurus


Description

Based on [Surh, 2003, figure 4](http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html). Nrf2 induces the expression of many antioxidant enzymes. It is therefore thought to be involved in oxidative stress response.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP3(79527) with a 89.0% conversion rate.

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Quality Tags

Image:Curated.pngApproved version
Image:Unconnected.pngFix interactions
Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

Bibliography

  1. Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137193
Approved
view23:23, 28 February 2025KhanspersModified description
105999view11:52, 16 August 2019MaintBotHMDB identifier normalization
80933view15:31, 30 June 2015Mkutmonhomology conversion
72383view15:30, 13 November 2013EgonwAdded a few metabolite identifiers.
72382view15:28, 13 November 2013EgonwFixed the PubChem-compound database name.
71409view19:01, 17 October 2013MaintBotAutomated update of data sources
63349view22:21, 9 May 2013MaintBotUpdated to 2013 gpml schema
40523view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
33630view10:04, 1 December 2009MaintBotRemoved group label
30557view22:02, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
6-HITCMetabolite7991398 (Chemspider) Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
AIMP2GeneProductENSBTAG00000007367 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7965
C/EBP-betaGeneProduct
Caffeic acid phenethyl esterMetaboliteCHEBI:8062 (ChEBI)
CurcuminMetaboliteHMDB0002269 (HMDB)
EPHB2GeneProductENSBTAG00000045902 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2048
GCLCGeneProductENSBTAG00000015571 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2729
GCLMGeneProductENSBTAG00000007842 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2730
GSTA2GeneProductENSBTAG00000006546 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2939
HMOX1GeneProductENSBTAG00000015582 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3162
KEAP1GeneProductENSBTAG00000003543 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9817
MAFGeneProductENSBTAG00000044192 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4094
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
NFE2L2GeneProductENSBTAG00000019255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4780
NQO1GeneProductENSBTAG00000020632 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1728
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PRKCAGeneProductENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
SLC7A11GeneProductENSBTAG00000034075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151012
SulforaphaneMetaboliteHMDB0005792 (HMDB)

Annotated Interactions

No annotated interactions
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