TCA cycle (Bos taurus)

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GTPGDPCO2waterNADH12103, 4, 13, 1467, 111, 1315MitochondrionIDH3ASDHAsuccinyl-CoAMetabolism of amino acidsDLSTcis-aconitateSUCLG2ACO2ACO2ATPSUCLG1ubiquinone-10NADPDegradation of Fatty AcidsNADNADADPFatty Acid SynthesisIDH2acetyl-CoAubiquinol-10CoANADPHsuccinateDLD(S)-malateIDH3GCoAFH2-oxoglutarateOGDHIDH3BSDHDwateroxaloacetateNADCSGlucose metabolismfumaratecitrateCoAMDH2SDHBNADHNADHD-threo-IsocitrateSDHCElectron Transport ChainwaterCO28CO25Pi2, 92, 9water


Description

The citric acid cycle, also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both Albert Szent-Gyorgyi and Hans Krebs. Source: Wikipedia (wikipedia:citric_acid_cycle)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP78(70014) with a 100.0% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Gabriel JL, Zervos PR, Plaut GW; ''Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria.''; Metabolism, 1986 PubMed Europe PMC Scholia
  2. Krebs HA, Holzach O; ''The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase.''; Biochem J, 1952 PubMed Europe PMC Scholia
  3. Des Rosiers C, Fernandez CA, David F, Brunengraber H; ''Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
  4. Comte B, Vincent G, Bouchard B, Benderdour M, Des Rosiers C; ''Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia.''; Am J Physiol Heart Circ Physiol, 2002 PubMed Europe PMC Scholia
  5. Johnson JD, Muhonen WW, Lambeth DO; ''Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  6. Sheu KF, Blass JP; ''The alpha-ketoglutarate dehydrogenase complex.''; Ann N Y Acad Sci, 1999 PubMed Europe PMC Scholia
  7. Fernandez CA, Des Rosiers C; ''Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  8. Lambeth DO, Tews KN, Adkins S, Frohlich D, Milavetz BI; ''Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  9. Lawson AM, Chalmers RA, Watts RW; ''Urinary organic acids in man. I. Normal patterns.''; Clin Chem, 1976 PubMed Europe PMC Scholia
  10. Liu TC, Kim H, Arizmendi C, Kitano A, Patel MS; ''Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient.''; Proc Natl Acad Sci U S A, 1993 PubMed Europe PMC Scholia
  11. Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, Fernandez CA, Brunengraber H; ''Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  12. Krebs, H. A., Johnson, W. A.; ''The Role of Citric Acid in Intermediate Metabolism in Animal Tissues.''; Enzymologia, 1937 PubMed Europe PMC Scholia
  13. Sazanov LA, Jackson JB; ''Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria.''; FEBS Lett, 1994 PubMed Europe PMC Scholia
  14. Hoek JB, Rydström J; ''Physiological roles of nicotinamide nucleotide transhydrogenase.''; Biochem J, 1988 PubMed Europe PMC Scholia
  15. Greksák M, Lopes-Cardozo M, van den Bergh SG; ''Citrate synthesis in intact rat-liver mitochondria is irreversible.''; Eur J Biochem, 1982 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
125338view22:45, 31 January 2023LarsgwAdd PMID to reference
117621view11:42, 21 May 2021EweitzModified title
105929view11:46, 16 August 2019MaintBotHMDB identifier normalization
80665view15:21, 30 June 2015Mkutmonhomology conversion
63454view17:17, 10 May 2013MaintBotupdating gpml
44775view10:53, 2 October 2011MartijnVanIerselabbreviated alpha to fit label
40588view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
33826view00:26, 9 December 2009MaintBotAutomatic update of empty xrefs
33640view10:07, 1 December 2009MaintBotRemoved group label
31645view22:28, 13 August 2009MaintBotFixed text labels
30568view22:05, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(S)-malateMetaboliteHMDB0000156 (HMDB)
2-oxoglutarateMetaboliteHMDB0000208 (HMDB)
ACO2GeneProductENSBTAG00000006429 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50
ADPMetaboliteHMDB0001341 (HMDB) The ChEBI ID with the correct charge is: 456216
ATPMetaboliteHMDB0000538 (HMDB) The ChEBI ID with the correct charge is: 30616
CO2MetaboliteHMDB0001967 (HMDB)
CSGeneProductENSBTAG00000004371 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1431
CoAMetaboliteHMDB0001423 (HMDB)
  • The ChEBI ID with the correct charge is: 57287
  • Type your comment here
D-threo-IsocitrateMetaboliteHMDB0000193 (HMDB) The ChEBI ID with the correct charge is: 15562
DLDGeneProductENSBTAG00000001908 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1738
DLSTGeneProductENSBTAG00000006463 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1743
Degradation of Fatty AcidsPathwayWP143 (WikiPathways)
Electron Transport ChainPathwayWP111 (WikiPathways)
FHGeneProductENSBTAG00000021688 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2271
Fatty Acid SynthesisPathwayWP357 (WikiPathways)
GDPMetaboliteHMDB0001201 (HMDB) The ChEBI ID with the correct charge is: 58189
GTPMetaboliteHMDB0001273 (HMDB) The ChEBI ID with the correct charge is: 37565
Glucose metabolismPathwayWP534 (WikiPathways)
IDH2GeneProductENSBTAG00000014093 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3418
IDH3AGeneProductENSBTAG00000006227 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3419
IDH3BGeneProductENSBTAG00000018813 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3420
IDH3GGeneProductENSBTAG00000001059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3421
MDH2GeneProductENSBTAG00000009462 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4191
Metabolism of amino acidsPathwayWP1847 (WikiPathways) Not all metabolic pathways of amino acids are connected to the TCa cycle.
NADHMetaboliteHMDB0001487 (HMDB) The ChEBI ID with the correct charge is: 57945
NADMetaboliteHMDB0000902 (HMDB)
NADPHMetaboliteHMDB0000221 (HMDB) The ChEBI ID with the correct charge is: 57783
NADPMetaboliteHMDB0000217 (HMDB)
OGDHGeneProductENSBTAG00000006029 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4967
PiMetaboliteHMDB0001429 (HMDB)
SDHAGeneProductENSBTAG00000046019 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6389
SDHBGeneProductENSBTAG00000008314 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6390
SDHCGeneProductENSBTAG00000015853 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6391
SDHDGeneProductENSBTAG00000016266 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6392
SUCLG1GeneProductENSBTAG00000006075 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8802
SUCLG2GeneProductENSBTAG00000009541 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8801
acetyl-CoAMetaboliteHMDB0001206 (HMDB) The ChEBI ID with the correct charge is: 57288
cis-aconitateMetaboliteHMDB0000072 (HMDB) The ChEBI ID with the correct charge is: 16383
citrateMetaboliteHMDB0000094 (HMDB)
fumarateMetaboliteHMDB0000134 (HMDB)
oxaloacetateMetaboliteHMDB0000223 (HMDB)
succinateMetaboliteHMDB0000254 (HMDB) The ChEBI ID with the correct charge is: 30031
succinyl-CoAMetaboliteHMDB0001022 (HMDB) The ChEBI ID with the correct charge is: 57292
ubiquinol-10MetaboliteHMDB0013111 (HMDB)
ubiquinone-10MetaboliteHMDB0001072 (HMDB)
waterMetaboliteHMDB0002111 (HMDB)

Annotated Interactions

No annotated interactions
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