Complement and coagulation cascades (Homo sapiens)
From WikiPathways
Description
The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Source: KEGG
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Bibliography
- ''''; https://www.genome.jp/dbget-bin/www_bget?pathway+map04610,
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
109821 | GeneProduct | 109821 (Entrez Gene) | |
A2M | GeneProduct | 2 (Entrez Gene) | |
ADN | GeneProduct | 1675 (Entrez Gene) | |
BDKRB1 | GeneProduct | 623 (Entrez Gene) | |
Bradykinin | Metabolite | 58-82-2 (CAS) | |
C1QA | GeneProduct | 712 (Entrez Gene) | |
C1QB | GeneProduct | 713 (Entrez Gene) | |
C1QG | GeneProduct | 714 (Entrez Gene) | |
C1R | GeneProduct | 715 (Entrez Gene) | |
C1S | GeneProduct | 716 (Entrez Gene) | |
C2 | GeneProduct | 717 (Entrez Gene) | |
C3 | GeneProduct | 718 (Entrez Gene) | |
C3AR1 | GeneProduct | 719 (Entrez Gene) | |
C4 | GeneProduct | 721 (Entrez Gene) | |
C5R1 | GeneProduct | 728 (Entrez Gene) | |
C6 | GeneProduct | 729 (Entrez Gene) | |
C7 | GeneProduct | 730 (Entrez Gene) | MGI:88235 LL:109828 |
C8G | GeneProduct | 733 (Entrez Gene) | |
C9 | GeneProduct | 735 (Entrez Gene) | |
CD59A | GeneProduct | ||
CFH | GeneProduct | 3075 (Entrez Gene) | |
CFI | GeneProduct | 3426 (Entrez Gene) | |
CLU | GeneProduct | 1191 (Entrez Gene) | CLU |
CPB2 | GeneProduct | 1361 (Entrez Gene) | |
CR1 | GeneProduct | 1378 (Entrez Gene) | |
CR2 | GeneProduct | 1380 (Entrez Gene) | |
CRRY | GeneProduct | ||
Daf1 | GeneProduct | 1604 (Entrez Gene) | |
Daf2 | GeneProduct | ||
F10 | GeneProduct | 2159 (Entrez Gene) | |
F12 | GeneProduct | 2161 (Entrez Gene) | |
F13B | GeneProduct | 2165 (Entrez Gene) | |
F2 | GeneProduct | 2147 (Entrez Gene) | |
F2R | GeneProduct | 2149 (Entrez Gene) | |
F3 | GeneProduct | 2152 (Entrez Gene) | |
F5 | GeneProduct | 2153 (Entrez Gene) | |
F7 | GeneProduct | 2155 (Entrez Gene) | |
F8 | GeneProduct | 2157 (Entrez Gene) | |
F9 | GeneProduct | 2158 (Entrez Gene) | |
FGB | GeneProduct | 2244 (Entrez Gene) | |
Fibrin monomer | Metabolite | 9001-31-4 (CAS) | |
H2-BF | GeneProduct | 629 (Entrez Gene) | |
Hc | GeneProduct | 1213 (Entrez Gene) | |
KLKB1 | GeneProduct | 3818 (Entrez Gene) | |
KNG1 | GeneProduct | 3827 (Entrez Gene) | |
MASP1 | GeneProduct | 5648 (Entrez Gene) | |
MASP2 | GeneProduct | 10747 (Entrez Gene) | |
MBL1 | GeneProduct | 3998 (Entrez Gene) | |
MCP | GeneProduct | 4179 (Entrez Gene) | |
PLAT | GeneProduct | 5327 (Entrez Gene) | |
PLAU | GeneProduct | 5328 (Entrez Gene) | |
PLAUR | GeneProduct | 5329 (Entrez Gene) | |
PLG | GeneProduct | 5340 (Entrez Gene) | |
PROC | GeneProduct | 5624 (Entrez Gene) | |
PROS1 | GeneProduct | 5627 (Entrez Gene) | |
SERPINA1 | GeneProduct | 5265 (Entrez Gene) | |
SERPINA5 | GeneProduct | 5104 (Entrez Gene) | |
SERPINC1 | GeneProduct | 462 (Entrez Gene) | |
SERPIND1 | GeneProduct | 3053 (Entrez Gene) | |
SERPINE1 | GeneProduct | 5054 (Entrez Gene) | |
SERPINF2 | GeneProduct | 5345 (Entrez Gene) | |
SERPING1 | GeneProduct | 710 (Entrez Gene) | |
TFPI | GeneProduct | 7035 (Entrez Gene) | |
THBD | GeneProduct | 7056 (Entrez Gene) | |
VWF | GeneProduct | 7450 (Entrez Gene) |
Annotated Interactions
No annotated interactions