Glutathione metabolism (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none 1.8.4.41.8.4.1GPX1GPX21.8.4.31.8.4.71.8.5.11.8.4.2GPX31.5.4.11.11.1.121.8.3.3GPX42.8.1.3Cyanoaminoacid metabolismAmino acid metabolismRXTaurine and hypotaurinemetabolismGlutamate metabolismGlutathioneutilizationg-GlutamylCycleGlutathione utilizationCysteine metabolismglutathione recycling2.3.1.80g-L-Glutamyl-L-cysteineL-CysteineGSRCysteinyl-glycineANPEP2.3.2.41.8.1.13Glycine5-OxoprolineGlycineGSSL-GlutamateNADPHL-Glutamate(5-L-Glutamyl)-L-amino acidR-S-MercapturonateL-Amino acidBis-g-glutamylcystineR-S-Alanine6.3.1.8Glutamylcysteinyl-glycylspermidineNADP+Glutathione (reduced)ANPEPR-S-AlanylglycineAcetyl-CoAOPLAHR-S-Glutathione2.3.2.4Oxidized glutathione3.5.1.78GSTA1GSTM2GSTA5GSTT2GSTT1GSTM1GGT1GGTLA1GGTLA1GGT13.4.11.4GGTLA1GGT1IDH11.1.1.43G6PDGCLCGCLMName: Glutathione metabolismOrganism: Homo sapiens


Description

Glutathione is a major antioxidant in all forms of life and an indicator of cellular oxidative stress. Reduction by the GSR enzyme utilizes NADPH as an electron donor. In a reduced form, glutathione is metabolized in multiple ways leading to the biosynthesis of mercapturonate, glutamate, glycine, cysteine and other amino acids. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP100)

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Quality Tags

Image:Curated.pngApproved version
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Ontology Terms

 

Bibliography

  1. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND; ''Glutathione metabolism and its implications for health.''; J Nutr, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137183
Approved
view08:32, 28 February 2025EgonwModified description
128959view14:56, 25 February 2024EgonwAdded a reference
107114view14:19, 17 September 2019MaintBotChEBI identifier normalization
106686view12:57, 17 September 2019MaintBotHMDB identifier normalization
106434view23:24, 28 August 2019KhanspersModified description
105610view04:54, 10 August 2019KhanspersModified description
104980view19:14, 27 June 2019KhanspersModified description
96097view22:52, 15 February 2018AlexanderPicoremoved old comments
96096view22:51, 15 February 2018AlexanderPicoModified description
93097view15:29, 28 July 2017DeSlChanged punchem sub for chebi ID
85643view17:06, 4 June 2016EgonwFixed the KEGG id.
74146view11:25, 1 April 2014EgonwReplaced an InChI with a more traditional identifier.
71272view22:18, 16 October 2013MaintBotAutomated update of data sources
63199view20:54, 8 May 2013MaintBotUpdating gpml version
54701view13:16, 7 December 2012Andra
53455view18:00, 7 November 2012Andra
53454view17:56, 7 November 2012Andra
53453view17:54, 7 November 2012AndraRDF TIdy
53450view17:16, 7 November 2012AndraAdded EC number as source after RDF tidy
48237view05:58, 17 May 2012MaintBotUpdating PubChem xrefs
45319view20:08, 7 October 2011AlexanderPicoOntology Term : 'glutathione metabolic pathway' added !
41200view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
32178view12:31, 15 August 2009MaintBotFixed text labels
31646view11:35, 14 August 2009MaintBotFixed group labels
20893view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Gluthation Metabolism KEGG]] moved to [[Pathway:WP100]]: Moved to stable identifier
13974view13:37, 20 May 2008Thomasfinished connectors
13972view13:15, 20 May 2008Thomasadding connectors
13969view12:38, 20 May 2008Thomasadded metabolite annotation
13967view12:34, 20 May 2008ThomasPeriodical save, work in progress
8084view13:46, 7 January 2008MaintBot[[Pathway:Human:Gluthation Metabolism KEGG]] moved to [[Pathway:Homo sapiens:Gluthation Metabolism KEGG]]: Renaming species
7664view16:08, 18 December 2007MaintBotfixed category names
7363view12:42, 4 November 2007MaintBotAdded categories to GPML
6327view22:17, 22 May 2007169.230.77.174gpml file for [[Human:Gluthation_Metabolism_KEGG]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
(5-L-Glutamyl)-L-amino acidMetaboliteC03740 (KEGG Compound)
1.1.1.43GeneProduct1.1.1.43 (Enzyme Nomenclature)
1.11.1.12GeneProduct1.11.1.12 (Enzyme Nomenclature)
1.5.4.1GeneProduct1.5.4.1 (Enzyme Nomenclature)
1.8.1.13GeneProduct1.8.1.13 (Enzyme Nomenclature)
1.8.3.3GeneProduct1.8.3.3 (Enzyme Nomenclature)
1.8.4.1GeneProduct1.8.4.1 (Enzyme Nomenclature)
1.8.4.2GeneProduct1.8.4.2 (Enzyme Nomenclature)
1.8.4.3GeneProduct1.8.4.3 (Enzyme Nomenclature)
1.8.4.4GeneProduct1.8.4.4 (Enzyme Nomenclature)
1.8.4.7GeneProduct1.8.4.7 (Enzyme Nomenclature)
1.8.5.1GeneProduct1.8.5.1 (Enzyme Nomenclature)
2.3.1.80GeneProduct2.3.1.80 (Enzyme Nomenclature)
2.3.2.4GeneProduct2.3.2.4 (Enzyme Nomenclature)
2.8.1.3GeneProduct2.8.1.3 (Enzyme Nomenclature)
3.4.11.4GeneProduct3.4.11.4 (Enzyme Nomenclature)
3.5.1.78GeneProduct3.5.1.78 (Enzyme Nomenclature)
5-OxoprolineMetaboliteC01879 (KEGG Compound)
6.3.1.8GeneProduct6.3.1.8 (Enzyme Nomenclature)
ANPEPGeneProduct290 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
Bis-g-glutamylcystineMetaboliteC03646 (KEGG Compound)
Cysteinyl-glycineMetaboliteC01419 (KEGG Compound)
G6PDGeneProduct2539 (Entrez Gene)
GCLCGeneProduct2729 (Entrez Gene)
GCLMGeneProduct2730 (Entrez Gene)
GGT1GeneProduct2678 (Entrez Gene)
GGTLA1GeneProduct2687 (Entrez Gene)
GPX1GeneProduct2876 (Entrez Gene)
GPX2GeneProduct2877 (Entrez Gene)
GPX3GeneProduct2878 (Entrez Gene)
GPX4GeneProduct2879 (Entrez Gene)
GSRGeneProduct2936 (Entrez Gene)
GSSGeneProduct2937 (Entrez Gene)
GSTA1GeneProduct2938 (Entrez Gene)
GSTA5GeneProduct221357 (Entrez Gene)
GSTM1GeneProduct2944 (Entrez Gene)
GSTM2GeneProduct2946 (Entrez Gene)
GSTT1GeneProduct2952 (Entrez Gene)
GSTT2GeneProduct2953 (Entrez Gene)
Glutamylcysteinyl-glycylspermidineMetabolite440772 (PubChem-compound)
Glutathione (reduced)MetaboliteC00051 (KEGG Compound)
GlycineMetaboliteHMDB0000123 (HMDB)
IDH1GeneProduct3417 (Entrez Gene)
L-Amino acidMetaboliteC00151 (KEGG Compound)
L-CysteineMetaboliteC00097 (KEGG Compound)
L-GlutamateMetaboliteC00025 (KEGG Compound)
NADP+MetaboliteHMDB0000217 (HMDB)
NADPHMetaboliteHMDB0000221 (HMDB)
OPLAHGeneProduct26873 (Entrez Gene)
Oxidized glutathioneMetaboliteC00127 (KEGG Compound)
R-S-AlanineMetaboliteC05726 (KEGG Compound)
R-S-AlanylglycineMetaboliteC05729 (KEGG Compound)
R-S-GlutathioneMetaboliteC02320 (KEGG Compound)
R-S-MercapturonateMetaboliteCHEBI:47911 (ChEBI)
g-L-Glutamyl-L-cysteineMetaboliteC00669 (KEGG Compound)

Annotated Interactions

No annotated interactions

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