DNA mismatch repair (Homo sapiens)
From WikiPathways
Description
In vitro MMR requires a nick requires a preexisting nick (single-strand gap) in the DNA substrate. Similarly, it is thought that for in vivo MMR in eukaryotes, newly synthesized lagging-strand DNA transiently contains nicks (before being sealed by DNA ligase) which provides a signal that directs mismatch proofreading systems to the appropriate strandThis pathway describes the slightly different mechanisms for MMR based on the location of the nick in relation to the mismatch (5' and 3').
Mutations in the genes coding human MutS and MutL homologs have been linked with the Lynch syndrome, which is characterized by an increased risk of developing cancer.
This pathway is based on figure 1 from Hsieh et al, with additional information from REPAIRtoire, Wikipedia and KEGG. The description was adapted from REPAIRtoire, layout is based on KEGG.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Bibliography
- Hsieh P, Zhang Y; ''The Devil is in the details for DNA mismatch repair.''; Proc Natl Acad Sci U S A, 2017 PubMed Europe PMC Scholia
- Iyer RR, Pluciennik A, Burdett V, Modrich PL; ''DNA mismatch repair: functions and mechanisms.''; Chem Rev, 2006 PubMed Europe PMC Scholia
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Annotated Interactions
No annotated interactions