Selenium metabolism and selenoproteins (Homo sapiens)

From WikiPathways

Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none SeCSBP2UnknownfunctionSelOSelISelTSelVSelHSe transportand storageSEPP1Selenium binding proteinsFabp1Selenbp1AUGSTOPAntioxidantenzymesGPX6GPX1SepX1GPX3SelKSepWGPX4GPX2Seryl-tRNA[ser](sec)methyl transferaseSelenoproteinsINORGANIC SeSelenateSeleniteORGANIC SeSeMetSeCSec tRNA[ser]secNucleusGSHSe = Selenium, SeMet = SelenoMethionine, SeC = Selcysteine, H2Se = Selenide, GSH = gluthatione, Trx = ThioredoxinPhosphoseryl-tRNA[ser](sec)SeCSecsynthesisSPS2SeC biosynthesisTrXcoding regionProtein foldingSelSSep15SEPN1SelMTranscription factorsSp1Pouf2f1CREMSp3JUNNfe2l2NFKB-p65NFKB-p105FOSThyroid hormonemetabolismDIO3DIO2DIO1DietSelenocysteyl-tRNA secBody proteinsRedox signalingTXNRD3TXNRD1TXNRD2demethylationRpl30Sephs2Sephs1Secp43SBP2eEFSecMethylSelenol MeSeHTXNRD3TXNRD1TXNRD2SeleniteSelenateSeCHydrogen selenideSelenophosphateeEFSecSclySarsSars2SlaCystathionine g-lyasePstkSBP2SeMetUGAName: Selenium metabolism and selenoproteinsLast Modified: 10/16/2013Organism: Homo sapiens


Description

Organic and inorganic sources of selenium from diet are metabolised by a series of reactions, leading to SeC biosynthesis and transcriptional regulation of a set of selenoproteins. Also refer to the selenoprotein database at [www.selenodb.org](http://www.selenodb.org). Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP28).

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:Wplogo_31.pngCommunity: Micronutrients
Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

View all...
  1. Boosalis MG; ''The role of selenium in chronic disease.''; Nutr Clin Pract, 2008 PubMed Europe PMC Scholia
  2. Commandeur JN, Andreadou I, Rooseboom M, Out M, de Leur LJ, Groot E, Vermeulen NP; ''''; , PubMed Europe PMC Scholia
  3. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF; ''Effectiveness of selenium supplements in a low-selenium area of China.''; Am J Clin Nutr, 2005 PubMed Europe PMC Scholia
  4. Small-Howard AL, Berry MJ; ''Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes.''; Biochem Soc Trans, 2005 PubMed Europe PMC Scholia
  5. Thompson HJ, Clement IP; ''''; , PubMed Europe PMC Scholia
  6. Wang H, Zhang J, Yu H; ''Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.''; Free Radic Biol Med, 2007 PubMed Europe PMC Scholia
  7. Soda K, Oikawa T, Esaki N; ''Vitamin B6 enzymes participating in selenium amino acid metabolism.''; Biofactors, 1999 PubMed Europe PMC Scholia
  8. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.''; Antioxid Redox Signal, 2007 PubMed Europe PMC Scholia
  9. Ip C, Hayes C; ''Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection.''; Carcinogenesis, 1989 PubMed Europe PMC Scholia
  10. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL; ''Biosynthesis of selenocysteine on its tRNA in eukaryotes.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
  11. Gromer S, Eubel JK, Lee BL, Jacob J; ''Human selenoproteins at a glance.''; Cell Mol Life Sci, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137819
Approved
view06:43, 8 March 2025EgonwModified description
137541view23:39, 3 March 2025AlexanderPicoAdded proper description and moved datanode comments to datanodes
137491view07:02, 3 March 2025EgonwModified description
129496
Micronutrients
view07:53, 2 May 2024SusanConnected lines
127987view22:58, 20 January 2024EweitzFix typos, economize layout
126431view10:10, 28 April 2023EgonwLicense is CCZero
116456view09:57, 7 May 2021EweitzModified title
109398view16:19, 16 March 2020L DupuisConverted interaction to graphical line
106490view21:41, 4 September 2019KhanspersModified description
106208view12:10, 16 August 2019MaintBotHMDB identifier normalization
105807view22:53, 15 August 2019KhanspersModified description
71888view09:47, 22 October 2013Mkutmonchanged FOS from Unknown to GeneProduct
71250view20:37, 16 October 2013MaintBotAutomated update of data sources
68932view17:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
68048view12:08, 29 June 2013EgonwAdded missing metabolite identifiers.
61686view22:01, 16 April 2013MaintBotupdated swissprot data source to uniprot/trembl
59121view22:28, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
46518view04:00, 10 February 2012Strandadded selenite identifier
46517view03:58, 10 February 2012Strandcorrected RefSeq identifier
46516view03:57, 10 February 2012Strandcorrect RefSeq identifiers
46500view23:22, 6 February 2012AlexanderPicofixed a refseq id
45019view18:38, 6 October 2011ThomasOntology Term : 'selenoamino acid metabolic pathway' added !
41081view23:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
39764view07:43, 17 January 2011AlexanderPicomore complete title
38852view17:58, 24 September 2010Khanspers
38755view22:36, 23 September 2010KhanspersChanged nucleus
37163view19:21, 19 May 2010EveloAdded backpages for selenite and hydrogen selenide
37162view19:12, 19 May 2010EveloCosmetic
35187view15:05, 11 February 2010EveloCosmetic changes and some backpages
35168view14:51, 11 February 2010EveloPeriodical save, work in progress
35155view14:25, 11 February 2010EveloPeriodical save, work in progress
35145view14:15, 11 February 2010EveloPeriodical save, work in progress
35135view14:04, 11 February 2010EveloPeriodical save, work in progress
32383view16:56, 15 August 2009MaintBotFixed text labels
32026view13:24, 14 August 2009MaintBotFixed group labels
30051view22:51, 29 June 2009Andraconnect line
30050view22:46, 29 June 2009AndraAdded references
29723view21:41, 1 June 2009Khanspersupdated Ensembl refs
28969view09:56, 19 March 2009SusanChanged NFKB-p65 ID
28934view11:26, 16 March 2009EveloPeriodical save, work in progress
28784view13:14, 6 March 2009EveloModified description
28781view13:02, 6 March 2009EveloAdded two gene ID's
28131view19:45, 27 January 2009KhanspersRemoved species code from name
20735view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Selenoproteins]] moved to [[Pathway:WP28]]: Moved to stable identifier
19220view14:57, 24 September 2008SusanGraphical adaptation
15890view14:12, 6 June 2008EgoyenecheaPeriodical save, work in progress
14945view16:09, 24 May 2008MartijnVanIersellinked up
14943view15:58, 24 May 2008MartijnVanIerselCreated metabolites
8382view13:46, 7 January 2008MaintBot[[Pathway:Human:Selenoproteins]] moved to [[Pathway:Homo sapiens:Selenoproteins]]: Renaming species
7808view16:19, 18 December 2007MaintBotfixed category names

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CREMGeneProductQ03060 (Uniprot-TrEMBL)
Cystathionine g-lyaseGeneProductNP_001893 (RefSeq) Cystathionine gamma-lyase is the mammalian form of bacterial methionine gamma-lyase.
DIO1GeneProduct1733 (Entrez Gene)
DIO2GeneProduct1734 (Entrez Gene)
DIO3GeneProduct1735 (Entrez Gene)
FOSGeneProductENSG00000170345 (Ensembl)
Fabp1GeneProduct2168 (Entrez Gene)
GPX1GeneProduct2876 (Entrez Gene)
GPX2GeneProduct2877 (Entrez Gene)
GPX3GeneProduct2878 (Entrez Gene)
GPX4GeneProduct2879 (Entrez Gene)
GPX6GeneProduct257202 (Entrez Gene)
Hydrogen selenideMetaboliteHMDB0011110 (HMDB)
JUNGeneProductENSG00000177606 (Ensembl)
MethylSelenol MeSeHMetabolite389633 (Chemspider)
NFKB-p105GeneProduct4790 (Entrez Gene)
NFKB-p65GeneProduct5970 (Entrez Gene)
Nfe2l2GeneProductNM_006164 (RefSeq)
Pouf2f1GeneProductP14859 (Uniprot-TrEMBL)
PstkGeneProductQ8IV42 (Uniprot-TrEMBL)
Rpl30GeneProduct6156 (Entrez Gene)
SBP2GeneProductQ96T21 (Uniprot-TrEMBL)
SEPN1GeneProduct57190 (Entrez Gene)
SEPP1GeneProduct6414 (Entrez Gene)
SPS2GeneProduct22928 (Entrez Gene)
Sars2GeneProduct54938 (Entrez Gene)
SarsGeneProductP49591 (Uniprot-TrEMBL)
SclyGeneProduct51540 (Entrez Gene)
SeCMetaboliteHMDB0003288 (HMDB)
SeMetMetaboliteHMDB0003966 (HMDB)
Secp43GeneProduct54952 (Entrez Gene)
SelHGeneProduct280636 (Entrez Gene)
SelIGeneProduct85465 (Entrez Gene)
SelKGeneProduct58515 (Entrez Gene)
SelMGeneProduct140606 (Entrez Gene)
SelOGeneProduct83642 (Entrez Gene)
SelSGeneProduct55829 (Entrez Gene)
SelTGeneProduct51714 (Entrez Gene)
SelVGeneProduct348303 (Entrez Gene)
SelenateMetabolite24657 (Chemspider)
Selenbp1GeneProduct8991 (Entrez Gene)
SeleniteMetaboliteHMDB0011119 (HMDB)
SelenophosphateMetaboliteHMDB0006407 (HMDB)
Sep15GeneProductO60613 (Uniprot-TrEMBL)
SepWGeneProduct6415 (Entrez Gene)
SepX1GeneProduct51734 (Entrez Gene)
Sephs1GeneProductP49903 (Uniprot-TrEMBL)
Sephs2GeneProductNP_036380 (RefSeq)
SlaGeneProduct51091 (Entrez Gene)
Sp1GeneProductNP_612482 (RefSeq)
Sp3GeneProduct6670 (Entrez Gene)
TXNRD1GeneProduct7296 (Entrez Gene)
TXNRD2GeneProduct10587 (Entrez Gene)
TXNRD3GeneProduct114112 (Entrez Gene) Although the geneID is correct, the sequence of this gene was guessed by analogy.
eEFSecGeneProduct60678 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP28"
Personal tools