Selenium metabolism and selenoproteins (Homo sapiens)

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2, 3, 5-7, 9...STOPORGANIC SeProtein foldingdemethylationAUGnucleusSe = Selenium, SeMet = SelenoMethionine, SeC = Selcysteine, H2Se = Selenide, GSH = gluthatione, Trx = ThioredoxinUnkownfunctionSeC BiosynthesisTranscription FactorsSelenocysteyl-tRNA secBody proteinsDietcoding regionSecsynthesisPhosphoseryl-tRNA[ser](sec)Se transportand storageSelenoproteinsSeCINORGANIC Semethyl transferaseSelenium binding proteinsAntioxidantenzymesTrXSeryl-tRNA[ser](sec)RedoxsignallingGSHSec tRNA[ser]secThyroid hormonemetabolismSeCSelTGPX3SelKDIO1TXNRD1SelMSep15NFKB-p105TXNRD1SelISBP2eEFSecTXNRD2CREMGPX4SBP2SarsSelenophosphateSelHSeleniteSepX1SeCSelenbp1TXNRD3Sars2Sephs2SeCFOSSclySephs1SEPN1Secp43SelSUGAPstkSBP2GPX1SEPP1GPX6Cystathionine g-lyaseSeMetSeleniteDIO2TXNRD3Pouf2f1SelenateHydrogen selenideNFKB-p65SPS2SelenateGPX2TXNRD2SepWSeMeteEFSecSelOSlaFabp1Sp1DIO3Nfe2l2Rpl30SelVJUNSp3MethylSelenol MeSeH1, 81, 4, 11


* Comments belonging to specific genes on the Selenoprotein pathway
    • TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy.
    • Cystathionine gamma-lyase is the mammalian form of bacterial methionine gamma-lyase
    • A selenoprotein database exists at:
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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  1. Thompson HJ, Clement IP; ''''; , PubMed Europe PMC Scholia
  2. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.''; Antioxid Redox Signal, 2007 PubMed Europe PMC Scholia
  3. Boosalis MG; ''The role of selenium in chronic disease.''; Nutr Clin Pract, 2008 PubMed Europe PMC Scholia
  4. Ip C, Hayes C; ''Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection.''; Carcinogenesis, 1989 PubMed Europe PMC Scholia
  5. Small-Howard AL, Berry MJ; ''Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes.''; Biochem Soc Trans, 2005 PubMed Europe PMC Scholia
  6. Commandeur JN, Andreadou I, Rooseboom M, Out M, de Leur LJ, Groot E, Vermeulen NP; ''''; , PubMed Europe PMC Scholia
  7. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL; ''Biosynthesis of selenocysteine on its tRNA in eukaryotes.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
  8. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF; ''Effectiveness of selenium supplements in a low-selenium area of China.''; Am J Clin Nutr, 2005 PubMed Europe PMC Scholia
  9. Gromer S, Eubel JK, Lee BL, Jacob J; ''Human selenoproteins at a glance.''; Cell Mol Life Sci, 2005 PubMed Europe PMC Scholia
  10. Soda K, Oikawa T, Esaki N; ''Vitamin B6 enzymes participating in selenium amino acid metabolism.''; Biofactors, 1999 PubMed Europe PMC Scholia
  11. Wang H, Zhang J, Yu H; ''Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.''; Free Radic Biol Med, 2007 PubMed Europe PMC Scholia


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126431view10:10, 28 April 2023EgonwLicense is CCZero
116456view09:57, 7 May 2021EweitzModified title
109398view16:19, 16 March 2020L DupuisConverted interaction to graphical line
106490view21:41, 4 September 2019KhanspersModified description
106208view12:10, 16 August 2019MaintBotHMDB identifier normalization
105807view22:53, 15 August 2019KhanspersModified description
71888view09:47, 22 October 2013Mkutmonchanged FOS from Unknown to GeneProduct
71250view20:37, 16 October 2013MaintBotAutomated update of data sources
68932view17:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
68048view12:08, 29 June 2013EgonwAdded missing metabolite identifiers.
61686view22:01, 16 April 2013MaintBotupdated swissprot data source to uniprot/trembl
59121view22:28, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
46518view04:00, 10 February 2012Strandadded selenite identifier
46517view03:58, 10 February 2012Strandcorrected RefSeq identifier
46516view03:57, 10 February 2012Strandcorrect RefSeq identifiers
46500view23:22, 6 February 2012AlexanderPicofixed a refseq id
45019view18:38, 6 October 2011ThomasOntology Term : 'selenoamino acid metabolic pathway' added !
41081view23:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
39764view07:43, 17 January 2011AlexanderPicomore complete title
38852view17:58, 24 September 2010Khanspers
38755view22:36, 23 September 2010KhanspersChanged nucleus
37163view19:21, 19 May 2010EveloAdded backpages for selenite and hydrogen selenide
37162view19:12, 19 May 2010EveloCosmetic
35187view15:05, 11 February 2010EveloCosmetic changes and some backpages
35168view14:51, 11 February 2010EveloPeriodical save, work in progress
35155view14:25, 11 February 2010EveloPeriodical save, work in progress
35145view14:15, 11 February 2010EveloPeriodical save, work in progress
35135view14:04, 11 February 2010EveloPeriodical save, work in progress
32383view16:56, 15 August 2009MaintBotFixed text labels
32026view13:24, 14 August 2009MaintBotFixed group labels
30051view22:51, 29 June 2009Andraconnect line
30050view22:46, 29 June 2009AndraAdded references
29723view21:41, 1 June 2009Khanspersupdated Ensembl refs
28969view09:56, 19 March 2009SusanChanged NFKB-p65 ID
28934view11:26, 16 March 2009EveloPeriodical save, work in progress
28784view13:14, 6 March 2009EveloModified description
28781view13:02, 6 March 2009EveloAdded two gene ID's
28131view19:45, 27 January 2009KhanspersRemoved species code from name
20735view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Selenoproteins]] moved to [[Pathway:WP28]]: Moved to stable identifier
19220view14:57, 24 September 2008SusanGraphical adaptation
15890view14:12, 6 June 2008EgoyenecheaPeriodical save, work in progress
14945view16:09, 24 May 2008MartijnVanIersellinked up
14943view15:58, 24 May 2008MartijnVanIerselCreated metabolites
8382view13:46, 7 January 2008MaintBot[[Pathway:Human:Selenoproteins]] moved to [[Pathway:Homo sapiens:Selenoproteins]]: Renaming species
7808view16:19, 18 December 2007MaintBotfixed category names
7496view13:10, 4 November 2007Thomastransfered literature references to GPML
7387view12:42, 4 November 2007MaintBotAdded categories to GPML
7189view12:31, 4 November 2007MaintBotAdded description to GPML
7104view13:08, 10 October 2007Susantest
7001view12:09, 9 August 2007SusanChanged gamma lyase

External references


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NameTypeDatabase referenceComment
CREMGeneProductQ03060 (Uniprot-TrEMBL)
Cystathionine g-lyaseGeneProductNP_001893 (RefSeq)
DIO1GeneProduct1733 (Entrez Gene)
DIO2GeneProduct1734 (Entrez Gene)
DIO3GeneProduct1735 (Entrez Gene)
FOSGeneProductENSG00000170345 (Ensembl)
Fabp1GeneProduct2168 (Entrez Gene)
GPX1GeneProduct2876 (Entrez Gene)
GPX2GeneProduct2877 (Entrez Gene)
GPX3GeneProduct2878 (Entrez Gene)
GPX4GeneProduct2879 (Entrez Gene)
GPX6GeneProduct257202 (Entrez Gene)
Hydrogen selenideMetaboliteHMDB0011110 (HMDB)
JUNGeneProductENSG00000177606 (Ensembl)
MethylSelenol MeSeHMetabolite389633 (Chemspider)
NFKB-p105GeneProduct4790 (Entrez Gene)
NFKB-p65GeneProduct5970 (Entrez Gene)
Nfe2l2GeneProductNM_006164 (RefSeq)
Pouf2f1GeneProductP14859 (Uniprot-TrEMBL)
PstkGeneProductQ8IV42 (Uniprot-TrEMBL)
Rpl30GeneProduct6156 (Entrez Gene)
SBP2GeneProductQ96T21 (Uniprot-TrEMBL)
SEPN1GeneProduct57190 (Entrez Gene)
SEPP1GeneProduct6414 (Entrez Gene)
SPS2GeneProduct22928 (Entrez Gene)
Sars2GeneProduct54938 (Entrez Gene)
SarsGeneProductP49591 (Uniprot-TrEMBL)
SclyGeneProduct51540 (Entrez Gene)
SeCMetaboliteHMDB0003288 (HMDB)
SeMetMetaboliteHMDB0003966 (HMDB)
Secp43GeneProduct54952 (Entrez Gene)
SelHGeneProduct280636 (Entrez Gene)
SelIGeneProduct85465 (Entrez Gene)
SelKGeneProduct58515 (Entrez Gene)
SelMGeneProduct140606 (Entrez Gene)
SelOGeneProduct83642 (Entrez Gene)
SelSGeneProduct55829 (Entrez Gene)
SelTGeneProduct51714 (Entrez Gene)
SelVGeneProduct348303 (Entrez Gene)
SelenateMetabolite24657 (Chemspider)
Selenbp1GeneProduct8991 (Entrez Gene)
SeleniteMetaboliteHMDB0011119 (HMDB)
SelenophosphateMetaboliteHMDB0006407 (HMDB)
Sep15GeneProductO60613 (Uniprot-TrEMBL)
SepWGeneProduct6415 (Entrez Gene)
SepX1GeneProduct51734 (Entrez Gene)
Sephs1GeneProductP49903 (Uniprot-TrEMBL)
Sephs2GeneProductNP_036380 (RefSeq)
SlaGeneProduct51091 (Entrez Gene)
Sp1GeneProductNP_612482 (RefSeq)
Sp3GeneProduct6670 (Entrez Gene)
TXNRD1GeneProduct7296 (Entrez Gene)
TXNRD2GeneProduct10587 (Entrez Gene)
TXNRD3GeneProduct114112 (Entrez Gene)
eEFSecGeneProduct60678 (Entrez Gene)

Annotated Interactions

No annotated interactions

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