Hepatocyte growth factor receptor signaling (Homo sapiens)
From WikiPathways
Description
Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
Quality Tags
Ontology Terms
Bibliography
- Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
CRK | GeneProduct | 1398 (Entrez Gene) | |
CRKL | GeneProduct | 1399 (Entrez Gene) | |
DOCK1 | GeneProduct | 1793 (Entrez Gene) | Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted) |
ELK1 | GeneProduct | 2002 (Entrez Gene) | |
FOS | GeneProduct | 2353 (Entrez Gene) | |
GAB1 | GeneProduct | 2549 (Entrez Gene) | |
GRB2 | GeneProduct | 2885 (Entrez Gene) | |
HGF | GeneProduct | 3082 (Entrez Gene) | |
HRAS | GeneProduct | 3265 (Entrez Gene) | |
ITGA1 | GeneProduct | 3672 (Entrez Gene) | |
ITGB1 | GeneProduct | 3688 (Entrez Gene) | |
JUN | GeneProduct | 3725 (Entrez Gene) | |
MAP2K1 | GeneProduct | 5604 (Entrez Gene) | |
MAP2K2 | GeneProduct | 5605 (Entrez Gene) | |
MAP4K1 | GeneProduct | 11184 (Entrez Gene) | |
MAPK1 | GeneProduct | 5594 (Entrez Gene) | |
MAPK3 | GeneProduct | 5595 (Entrez Gene) | |
MAPK8 | GeneProduct | 5599 (Entrez Gene) | |
Met | GeneProduct | 4233 (Entrez Gene) | |
PAK1 | GeneProduct | 5058 (Entrez Gene) | |
PIK3CA | GeneProduct | 5290 (Entrez Gene) | |
PTEN | GeneProduct | 5728 (Entrez Gene) | |
PTK2 | GeneProduct | 5747 (Entrez Gene) | |
PTK2B | GeneProduct | 2185 (Entrez Gene) | |
PTPN11 | GeneProduct | 5781 (Entrez Gene) | |
PXN | GeneProduct | 5829 (Entrez Gene) | |
RAF1 | GeneProduct | 5894 (Entrez Gene) | |
RAP1A | GeneProduct | 5906 (Entrez Gene) | |
RAP1B | GeneProduct | 5908 (Entrez Gene) | |
RAPGEF1 | GeneProduct | 2889 (Entrez Gene) | |
RASA1 | GeneProduct | 5921 (Entrez Gene) | |
SOS1 | GeneProduct | 6654 (Entrez Gene) | Son of sevenless homolog 1 (Drosophila) (predicted) |
SRC | GeneProduct | 6714 (Entrez Gene) | |
STAT3 | GeneProduct | 6774 (Entrez Gene) |
Annotated Interactions
No annotated interactions