S1P receptor signal transduction (Homo sapiens)
From WikiPathways
Description
Metabolism of sphingomyelin by the sphingomyelinase, ceramidase (Cer'ase) and the sphingosine kinase (SK) enzymes results in formation of S1P and receptor activation. Autocrine and paracrine modes of receptor activation have been implied but have yet to be rigorously proven. Critical signaling molecules, such as phospholipase C (PLC), ERK, PI3K, and Akt are activated. Active Akt binds to the receptor and phosphorylates the third intracellular loop, which is essential for Rac activation. Representation of Figure 2. from T. Hla, et al. 2001, Science, 294, pg. 1877.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Quality Tags
Ontology Terms
Bibliography
- Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ; ''Lysophospholipids--receptor revelations.''; Science, 2001 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | GeneProduct | 207 (Entrez Gene) | |
AKT2 | GeneProduct | 208 (Entrez Gene) | |
AKT3 | GeneProduct | 10000 (Entrez Gene) | |
ASAH1 | GeneProduct | 427 (Entrez Gene) | |
EDG3 | GeneProduct | 1903 (Entrez Gene) | |
EDG5 | GeneProduct | 9294 (Entrez Gene) | |
EDG8 | GeneProduct | 53637 (Entrez Gene) | |
GNAI1 | GeneProduct | 2770 (Entrez Gene) | |
GNAI2 | GeneProduct | 2771 (Entrez Gene) | |
GNAI3 | GeneProduct | 2773 (Entrez Gene) | |
MAPK12 | GeneProduct | 6300 (Entrez Gene) | |
MAPK1 | GeneProduct | 5594 (Entrez Gene) | |
MAPK3 | GeneProduct | 5595 (Entrez Gene) | |
MAPK4 | GeneProduct | 5596 (Entrez Gene) | |
MAPK6 | GeneProduct | 5597 (Entrez Gene) | |
MAPK7 | GeneProduct | 5598 (Entrez Gene) | |
PIK3C2B | GeneProduct | 5287 (Entrez Gene) | |
PLCB1 | GeneProduct | 23236 (Entrez Gene) | |
PLCB2 | GeneProduct | 5330 (Entrez Gene) | |
PLCB3 | GeneProduct | 5331 (Entrez Gene) | |
RACGAP1 | GeneProduct | 29127 (Entrez Gene) | |
S1PR1 | GeneProduct | 1901 (Entrez Gene) | |
SMPD2 | GeneProduct | 6610 (Entrez Gene) | |
SPHK1 | GeneProduct | 8877 (Entrez Gene) | |
SPHK2 | GeneProduct | 56848 (Entrez Gene) |
Annotated Interactions
No annotated interactions