Glucocorticoid and mineralcorticoid metabolism (Mus musculus)
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3a,11b,21-Trihydroxy-20-Oxo-
5b-Pregnan-18-al
Glucocorticoids
11-Deoxycorticosterone
Urocortisol
3
Glucuronides
11b, 21-Dihydroxy-3,20-
5b-Pregnan-18-al
*
3B-OH-delta-steroid Dh
*
*
5b-Pregnane-3,20-dione
11-Deoxycortisol
Urocortisone
Pregnane 3,20-dione
11b,17a 21-Trihydroxy-5b
20b-Hydroxysteroid Dh
Cyp21a1
Progesterone degradation
3a-Hydroxysteroid Dh
17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione
Corticosterone
Cholesterol biosynthesis
Cortolone
17-a-Hydroxyprogesterone
Hsd3b6
17a-Hydroxypregnenolone
Cholesterol
Metabolite
Cortisol
Cyp11b2
Cortisol
Hsd3b2
3alpha-Hydroxy-5beta-pregnane-20-one
Akr1c21
Hsd3b1
Cyp11a1
Cyp11b2
Cyp17a1
Pregnenolone
Androgen synthesis
and metabolism
Hsd3b5
Hsd3b1
Pregnanediol
18-Hydroxycorticosterone
Cyp17a1
Cortisone
3-Oxo-5b-Steroid Dh
(R)20-hydroxysteroid Dh
Hsd3b3
Aldosterone
Progesterone
Steroid hormone
signaling
Hsd11b2
Hsd11b1
Hsd3b1
Hsd3b4
Cortisone beta-reductase
Description
Pathway will be compared to
Human version
when curated, followed by homology conversion.
Comments
GenMAPP remarks
Adapted from
http://au.expasy.org/tools/pathways/
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Bibliography
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History
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Compare
Revision
Action
Time
User
Comment
128039
view
21:32, 21 January 2024
Eweitz
Connect interactions, refine to mim-catalysis
128038
view
20:32, 21 January 2024
Eweitz
Upgrade pathway representations
118582
view
13:40, 28 May 2021
Eweitz
Modified title
114020
view
15:19, 17 December 2020
NhungP
Connecting lines
112996
view
15:18, 29 October 2020
DeSl
Modified description
112995
view
15:16, 29 October 2020
DeSl
Changed title, removed structural drawings
106899
view
13:37, 17 September 2019
MaintBot
HMDB identifier normalization
71740
view
20:18, 17 October 2013
MaintBot
Automated update of data sources
71325
view
17:17, 17 October 2013
MaintBot
Automated update of data sources
69138
view
18:16, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67283
view
10:31, 26 June 2013
Christine Chichester
Ontology Term : 'C21-steroid hormone biosynthetic pathway' added !
62838
view
04:59, 3 May 2013
MaintBot
Updated UniProt data source
41327
view
00:25, 2 March 2011
MaintBot
Removed redundant pathway information and comments
33388
view
14:43, 30 November 2009
MaintBot
Removed group label
32963
view
21:54, 28 September 2009
MaintBot
Periodical save, work in progress
32962
view
21:23, 28 September 2009
MaintBot
Added metabolites and connectors
32961
view
21:10, 28 September 2009
MaintBot
added metabolites and connectors
32960
view
21:05, 28 September 2009
MaintBot
Periodical save, work in progress
32959
view
20:55, 28 September 2009
MaintBot
Periodical save, work in progress
21720
view
11:32, 14 November 2008
MaintBot
[[Pathway:Mus musculus:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:WP495]]: Moved to stable identifier
8080
view
13:46, 7 January 2008
MaintBot
[[Pathway:Mouse:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:Mus musculus:Glucocorticoid Mineralocorticoid Metabolism]]: Renaming species
7662
view
16:08, 18 December 2007
MaintBot
fixed category names
7361
view
12:42, 4 November 2007
MaintBot
Added categories to GPML
7108
view
13:20, 10 October 2007
Michiel
Specify description
7107
view
13:19, 10 October 2007
Michiel
Specify description
7106
view
13:17, 10 October 2007
Michiel
test
7105
view
13:15, 10 October 2007
Michiel
test
7101
view
12:57, 10 October 2007
Michiel
Test
19472
view
22:19, 22 May 2007
M.Lieberman
gpml file for [[Mouse:Glucocorticoid_Mineralocorticoid_Metabolism]]
6450
view
22:19, 22 May 2007
Nsalomonis
gpml file for [[Mouse:Glucocorticoid_Mineralocorticoid_Metabolism]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
(R)20-hydroxysteroid Dh
GeneProduct
17-a-Hydroxyprogesterone
Metabolite
17a-Hydroxypregnenolone
Metabolite
HMDB0000363 (HMDB)
17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione
Metabolite
HMDB0006758 (HMDB)
18-Hydroxycorticosterone
Metabolite
HMDB0000319 (HMDB)
20b-Hydroxysteroid Dh
GeneProduct
3-Oxo-5b-Steroid Dh
GeneProduct
3a-Hydroxysteroid Dh
GeneProduct
3alpha-Hydroxy-5beta-pregnane-20-one
Metabolite
HMDB0006759 (HMDB)
Akr1c21
GeneProduct
77337 (Entrez Gene)
SP, mouse EST: AW611181, rat SP: DIDH RAT
Aldosterone
Metabolite
HMDB0000037 (HMDB)
Androgen synthesis
and metabolism
Pathway
Cholesterol biosynthesis
Pathway
WP103 (WikiPathways)
Cholesterol
Metabolite
HMDB0000067 (HMDB)
Corticosterone
Metabolite
HMDB0001547 (HMDB)
Cortisol
Metabolite
HMDB0000063 (HMDB)
Cortisone beta-reductase
GeneProduct
Cortisone
Metabolite
HMDB0002802 (HMDB)
Cortolone
Metabolite
HMDB0003128 (HMDB)
Cyp11a1
GeneProduct
13070 (Entrez Gene)
Cyp11b2
GeneProduct
13072 (Entrez Gene)
EC number: 1.14.15.5
Cyp17a1
GeneProduct
13074 (Entrez Gene)
Cyp21a1
GeneProduct
13079 (Entrez Gene)
Hsd11b1
GeneProduct
15483 (Entrez Gene)
Hsd11b2
GeneProduct
15484 (Entrez Gene)
Hsd3b1
GeneProduct
15492 (Entrez Gene)
Hsd3b2
GeneProduct
15493 (Entrez Gene)
Hsd3b3
GeneProduct
15494 (Entrez Gene)
Hsd3b4
GeneProduct
15495 (Entrez Gene)
Hsd3b5
GeneProduct
15496 (Entrez Gene)
Hsd3b6
GeneProduct
15497 (Entrez Gene)
Metabolite
Metabolite
Pregnanediol
Metabolite
HMDB0004025 (HMDB)
Pregnenolone
Metabolite
HMDB0000253 (HMDB)
Progesterone degradation
Pathway
Progesterone
Metabolite
HMDB0001830 (HMDB)
Steroid hormone signaling
Pathway
Annotated Interactions
No annotated interactions
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Discussion
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DataNodes
and metabolism
Annotated Interactions
No annotated interactions