Hepatocyte growth factor receptor signaling (Mus musculus)

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1RHOpathwayCDC42pathwayTrancriptionCytoplasmAKT pathwayTranscriptionExtracellularRAC1pathwayAnoikisActinChanges in cytoskeletonand cell mobilityTranscriptionof Cox2AP-1PtenItga1CrklMetStat3Elk1CrkPak1Mapk8Map2k1Pik3caRasa1Mapk3Mapk1Rap1bPtk2PxnRap1aRaf1Hras1HgfDock1Map4k1PxnGrb2Ptk2bSrcMap2k2Sos1Ptk2bFosPtk2Gab1Ptpn11Itgb1Rapgef1SrcJunPPP


Description

Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP313(r21339) with a 97% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120784view01:55, 6 January 2022EweitzRefine case
118815view07:59, 2 June 2021DeSlConverted "P" to States
118814view07:54, 2 June 2021DeSlRemoved textlabel
118813view07:54, 2 June 2021DeSlConverted ReceptorSquare to MIM binding with lit. ref.
118812view07:51, 2 June 2021DeSlOntology Term : 'hepatocyte' added !
118810view07:51, 2 June 2021DeSlOntology Term : 'Rho/Rac/Cdc42 mediated signaling pathway' added !
118808view07:50, 2 June 2021DeSlAdded description from WP313
116711view09:44, 11 May 2021EweitzModified title
88163view08:29, 29 July 2016Mkutmongraphical lines
69178view18:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67645view11:43, 26 June 2013DdiglesOntology Term : 'scatter factor/hepatocyte growth factor signaling pathway' added !
41367view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
33054view19:14, 8 October 2009Khanspersadded xref
32360view13:42, 15 August 2009MaintBotFixed text labels
31994view13:15, 14 August 2009MaintBotFixed group labels
31406view20:51, 13 August 2009MaintBotFixed text labels
30880view00:16, 30 July 2009MaintBotConverted from Homo sapiens
21085view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Signaling of Hepatocyte Growth Factor Receptor Biocarta]] moved to [[Pathway:WP193]]: Moved to stable identifier
8386view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Signaling of Hepatocyte Growth Factor Receptor Biocarta]] moved to [[Pathway:Mus musculus:Signaling of Hepatocyte Growth Factor Receptor Biocarta]]: Renaming species
7810view16:19, 18 December 2007MaintBotfixed category names
7296view12:41, 4 November 2007MaintBotAdded categories to GPML
6493view22:19, 22 May 2007169.230.77.174gpml file for [[Mouse:Signaling_of_Hepatocyte_Growth_Factor_Receptor_Biocarta]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CrkGeneProduct12928 (Entrez Gene)
CrklGeneProduct12929 (Entrez Gene)
Dock1GeneProduct330662 (Entrez Gene) Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
Elk1GeneProduct13712 (Entrez Gene)
FosGeneProduct14281 (Entrez Gene)
Gab1GeneProduct14388 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
HgfGeneProduct15234 (Entrez Gene)
Hras1GeneProduct15461 (Entrez Gene)
Itga1GeneProduct109700 (Entrez Gene)
Itgb1GeneProduct16412 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Map4k1GeneProduct26411 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
MetGeneProduct17295 (Entrez Gene)
Pak1GeneProduct18479 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
PtenGeneProduct19211 (Entrez Gene)
Ptk2GeneProduct14083 (Entrez Gene)
Ptk2bGeneProduct19229 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
PxnGeneProduct19303 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
Rap1aGeneProduct109905 (Entrez Gene)
Rap1bGeneProduct215449 (Entrez Gene)
Rapgef1GeneProduct107746 (Entrez Gene)
Rasa1GeneProduct218397 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene) Son of sevenless homolog 1 (Drosophila) (predicted)
SrcGeneProduct20779 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP193"
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