Statin pathway (Mus musculus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none TriglyceridesLiver cellPhospholipidIDLFatty acidHDLLDLCell membraneTissuePlasmaVLDLCholesterol esterLrp1LipcCholesterolCetpApoa4CholesterolDgat1LplScarb1PltpLdlrAbca1Cyp7a1HmgcrStatinApoa1Soat1Cholic acidAcetyl-CoALcatMttpApoc3Apoc2Apoc1ApoeGroup objectName: Statin pathwayOrganism: Mus musculus


Description

Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. Sources: [PharmGKB](https://www.pharmgkb.org/pathway/PA2031) and [Wikipedia](http://en.wikipedia.org/wiki/Statin)

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

  1. Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137182
Approved
view08:31, 28 February 2025EgonwModified description
134146view19:55, 5 July 2024EweitzEconomize layout
134145view19:44, 5 July 2024EweitzEconomize layout
134144view19:32, 5 July 2024EweitzEconomize layout
134140view12:40, 3 July 2024EweitzStandardize font size
134139view12:39, 3 July 2024EweitzEase nomenclature, standardize case
127970view15:30, 20 January 2024EweitzIncrease node font size, standardize case
127969view15:25, 20 January 2024EweitzOntology Term : 'hepatocyte' added !
117947view10:46, 23 May 2021EweitzModified title
107192view14:28, 17 September 2019MaintBotChEBI identifier normalization
106833view13:31, 17 September 2019MaintBotHMDB identifier normalization
103264view07:46, 20 February 2019EgonwMore specific ChEBI identifier.
102612view19:50, 11 January 2019KhanspersOntology Term : 'cardiovascular system disease' added !
102611view19:50, 11 January 2019KhanspersOntology Term : 'hypercholesterolemia pathway' added !
102294view19:17, 17 December 2018KhanspersModified description
102291view19:14, 17 December 2018KhanspersModified description
73346view19:53, 22 January 2014EgonwAdded ChEBI identifiers to three metabolite classes.
69109view18:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
67656view11:45, 26 June 2013DdiglesOntology Term : 'statin drug pathway' added !
53530view19:14, 8 November 2012EgonwUpdated the CHEBI id format (see http://www.pathvisio.org/ticket/1439)
53452view17:29, 7 November 2012AndraAdded entrez gene identifier of Cetp after RDF tidy
50199view14:21, 9 August 2012Mkutmonadded new shape forms, added xref for statin and cholesterol ester
41296view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
38714view19:31, 23 September 2010AlexanderPico
35542view14:19, 12 February 2010Thomasremoved genmapp remark
35540view14:18, 12 February 2010ThomasModified description
35537view14:16, 12 February 2010Thomasadded literature, fixed title
33728view23:21, 8 December 2009KhanspersAdded connectors and metabolites
33727view23:12, 8 December 2009KhanspersPeriodical save, work in progress
29016view05:30, 27 March 2009AlexanderPicoReverted to version '04:29, 14 November 2008' by AlexanderPico
29015view05:30, 27 March 2009AlexanderPicoReverted to version '06:05, 14 November 2008' by AlexanderPico
22540view13:05, 14 November 2008TestUserSoap test - 1226667890445
22538view13:05, 14 November 2008TestUserSoap test - 1226667859184
20671view11:29, 14 November 2008MaintBot[[Pathway:Mus musculus:Statin Pathway PharmGKB]] moved to [[Pathway:WP1]]: Moved to stable identifier
11887view18:21, 8 May 2008KhanspersChanged contact info
8404view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Statin Pathway PharmGKB]] moved to [[Pathway:Mus musculus:Statin Pathway PharmGKB]]: Renaming species
7819view16:20, 18 December 2007MaintBotfixed category names
7396view12:42, 4 November 2007MaintBotAdded categories to GPML
19544view22:19, 22 May 2007BruceConklingpml file for [[Mouse:Statin_Pathway_PharmGKB]]
6496view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:Statin_Pathway_PharmGKB]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
Abca1GeneProduct11303 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
Apoa1GeneProduct11806 (Entrez Gene)
Apoa4GeneProduct11808 (Entrez Gene)
Apoc1GeneProduct11812 (Entrez Gene)
Apoc2GeneProduct11813 (Entrez Gene)
Apoc3GeneProduct11814 (Entrez Gene)
ApoeGeneProduct11816 (Entrez Gene)
CetpGeneProduct1071 (Entrez Gene)
Cholesterol esterMetaboliteCHEBI:17002 (ChEBI)
CholesterolMetaboliteHMDB0000067 (HMDB)
Cholic acidMetaboliteHMDB0000619 (HMDB)
Cyp7a1GeneProduct13122 (Entrez Gene)
Dgat1GeneProduct13350 (Entrez Gene)
Fatty acidMetaboliteCHEBI:35366 (ChEBI)
HmgcrGeneProduct15357 (Entrez Gene)
LcatGeneProduct16816 (Entrez Gene)
LdlrGeneProduct16835 (Entrez Gene)
LipcGeneProduct15450 (Entrez Gene)
LplGeneProduct16956 (Entrez Gene)
Lrp1GeneProduct16971 (Entrez Gene)
MttpGeneProduct17777 (Entrez Gene)
PhospholipidMetaboliteCHEBI:16247 (ChEBI)
PltpGeneProduct18830 (Entrez Gene)
Scarb1GeneProduct20778 (Entrez Gene)
Soat1GeneProduct20652 (Entrez Gene)
StatinMetaboliteCHEBI:87631 (ChEBI)
TriglyceridesMetaboliteCHEBI:17855 (ChEBI)

Annotated Interactions

No annotated interactions

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