This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal.
A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1)
and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted
that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells.
Interactions and object/gene groups for the pathway exist for the majority of components.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway WP399(79474) with a 99.0% conversion rate.
Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.''; Proc Natl Acad Sci U S A, 2007 PubMedEurope PMCScholia
Pereira L, Yi F, Merrill BJ; ''Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.''; Mol Cell Biol, 2006 PubMedEurope PMCScholia
Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMedEurope PMCScholia
Yi F, Pereira L, Merrill BJ; ''Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal.''; Stem Cells, 2008 PubMedEurope PMCScholia
Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.''; Methods Mol Biol, 2006 PubMedEurope PMCScholia
''Kegg version of this pathway''; http://www.genome.jp/kegg/pathway/hsa/hsa04310.html,
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No annotated interactions