TGF-beta receptor signaling (Bos taurus)

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Fix interactions Comment: 9 out of 47 lines are not properly connected. Please help improving this pathway by connecting the ends of interactions to nodes.

Approved version The current version of this pathway was approved for data analysis by Kristina Hanspers.

Annotate nodes Comment: 1 out of 62 DataNodes have a missing external reference. Check DataNode table at the bottom of the page. Please help improve this pathway by annotating gene, protein and metabolite nodes.

Homology Converted Comment: Inferred from another species Revision {{{tag_revision}}} of this pathway has been inferred from another species (tagged by Maintenance bot). Expression error: Unrecognised punctuation character "{"

Ontology Terms

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Bibliography

1. Ivey KN, Srivastava D; ''MicroRNAs as regulators of differentiation and cell fate decisions.''; Cell Stem Cell, 2010 PubMed Europe PMC Scholia
2. Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed Europe PMC Scholia
3. Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
BAMBI	GeneProduct	ENSBTAG00000003045 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25805
BMP4	GeneProduct	ENSBTAG00000003835 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:652
CREBBP	GeneProduct	ENSBTAG00000026403 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1387
CTNNB1	GeneProduct	ENSBTAG00000016420 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
EGF	GeneProduct
ENG	GeneProduct	ENSBTAG00000008997 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2022
EP300	GeneProduct	ENSBTAG00000016198 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
FKBP1A	GeneProduct	ENSBTAG00000032651 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2280
FOS	GeneProduct	ENSBTAG00000004322 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
FOXH1	GeneProduct	ENSBTAG00000004761 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8928
FST	GeneProduct	ENSBTAG00000003329 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10468
HRAS	GeneProduct	ENSBTAG00000046644 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
IFNG	GeneProduct	ENSBTAG00000012529 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
INHBA	GeneProduct	ENSBTAG00000002912 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624
ITGB6	GeneProduct	ENSBTAG00000009080 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3694
JAK1	GeneProduct	ENSBTAG00000003147 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JUN	GeneProduct	ENSBTAG00000004037 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
LEF1	GeneProduct	ENSBTAG00000006844 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51176
LEFTY1	GeneProduct	ENSBTAG00000002855 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10637
LEFTY2	GeneProduct	ENSBTAG00000002855 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7044
LIF	GeneProduct	ENSBTAG00000007424 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3976
LTBP1	GeneProduct	ENSBTAG00000019839 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4052
MAPK3	GeneProduct	ENSBTAG00000016156 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPK9	GeneProduct	ENSBTAG00000004709 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
NFKB1	GeneProduct	ENSBTAG00000020270 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NOG	GeneProduct	ENSBTAG00000040282 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9241
RUNX2	GeneProduct	ENSBTAG00000004104 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:860
RUNX3	GeneProduct	ENSBTAG00000019800 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:864
SERPINE1	GeneProduct	ENSBTAG00000014465 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5054
SKI	GeneProduct	ENSBTAG00000038716 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6497
SKIL	GeneProduct	ENSBTAG00000004154 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6498
SMAD1	GeneProduct	ENSBTAG00000002835 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4086
SMAD2	GeneProduct	ENSBTAG00000039916 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4087
SMAD3	GeneProduct	ENSBTAG00000012599 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088
SMAD4	GeneProduct	ENSBTAG00000006919 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
SMAD5	GeneProduct	ENSBTAG00000021772 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4090
SMAD6	GeneProduct	ENSBTAG00000000625 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4091
SMAD7	GeneProduct	ENSBTAG00000012441 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4092
SMAD9	GeneProduct	ENSBTAG00000007589 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4093
SPP1	GeneProduct	ENSBTAG00000005260 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6696
STAT1	GeneProduct	ENSBTAG00000007867 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3	GeneProduct	ENSBTAG00000021523 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
TFE3	GeneProduct	ENSBTAG00000008523 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7030
TGFB1	GeneProduct	ENSBTAG00000020457 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
TGFBR1	GeneProduct	ENSBTAG00000018035 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7046
TGFBR2	GeneProduct	ENSBTAG00000019832 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7048
TGFBR3	GeneProduct	ENSBTAG00000024269 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7049
TGIF1	GeneProduct	ENSBTAG00000007718 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7050
THBS1	GeneProduct	ENSBTAG00000002006 (Ensembl)	there are 5 types of tsp HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7057
TNF	GeneProduct	ENSBTAG00000025471 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
WNT1	GeneProduct	ENSBTAG00000015364 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7471
ZEB2	GeneProduct	ENSBTAG00000012615 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9839
ZFYVE9	GeneProduct	ENSBTAG00000014289 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9372
ZNF423	GeneProduct	ENSBTAG00000017397 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23090
bta-mir-302a	GeneProduct	ENSBTAG00000036428 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207927

Annotated Interactions