Translation factors (Homo sapiens)

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1m7GCap Binding ComplexAAAAAAAAAAAAAAARecruitment of 43SPre-initiation Complex40S SubunitGuanine Nucleotide ExchangeElongationscanningTerminationmRNARecruitment of 60S subunitand first peptide bondBinds aminoacyl-tRNATranslocation60S SubunitInitiation43S Pre-initiation ComplexAUGEIF4G1EIF3S10EIF4EBP3EIF4EBP2EEF1A1EIF4A1EIF1AYSUI1EIF3S9EIF4EBP1EEF2EIF3S1EIF5AEIF4EEIF2B4EEF2KEIF1AXITGB4BPEIF2S2EIF5EIF4A2EIF3S6EIF4BEIF2B5EEF1B2EIF2B2EEF1GEIF2AK3WBSCR1PAIP1EIF2AK1EEF1A2EIF2AK2EIF2B1EIF4G3EIF5BGSPT2ETF1EIF3S7KIAA0664EIF3S8EIF2S1EIF3S3EIF2S3EIF3S5PABPC1EIF3S4EIF3S2SUI1EEF1DEIF2B3


Description

Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. This pathway gives an overview of the translation factors involved in this process. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dever TE; ''Gene-specific regulation by general translation factors.''; Cell, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126266view15:54, 19 April 2023EgonwLicense is CCZero
117851view15:18, 22 May 2021EweitzModified title
105846view23:13, 15 August 2019KhanspersModified description
89328view09:52, 4 September 2016Mkutmonfix unconnected lines
78489view10:28, 7 January 2015MaintBotadded missing graphIds
69767view11:28, 11 July 2013Mkutmonreplace annotation lines with graphical lines (instead of interactions)
68881view17:25, 8 July 2013MaintBotUpdated to 2013 gpml schema
45069view20:11, 6 October 2011KhanspersOntology Term : 'translation pathway' added !
41026view23:13, 1 March 2011MaintBotRemoved redundant pathway information and comments
38845view17:44, 24 September 2010Khanspers
37349view18:08, 28 May 2010Khanspersconnectors
35489view12:30, 12 February 2010MichielModified description
35485view12:26, 12 February 2010MichielAdded ref
32212view12:43, 15 August 2009MaintBotFixed text labels
31702view11:50, 14 August 2009MaintBotFixed group labels
29787view20:56, 2 June 2009Khansperslayout changes
20907view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Translation Factors]] moved to [[Pathway:WP107]]: Moved to stable identifier
14917view14:58, 24 May 2008MartijnVanIersellinked up
13016view11:06, 17 May 2008MaintBotSticky edges patch by Sjoerd
8452view13:46, 7 January 2008MaintBot[[Pathway:Human:Translation Factors]] moved to [[Pathway:Homo sapiens:Translation Factors]]: Renaming species
7842view16:22, 18 December 2007MaintBotfixed category names
7310view12:42, 4 November 2007MaintBotAdded categories to GPML
6400view22:18, 22 May 2007Kdahlquistgpml file for [[Human:Translation_Factors]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
EEF1A1GeneProduct1915 (Entrez Gene)
EEF1A2GeneProduct1917 (Entrez Gene)
EEF1B2GeneProduct1933 (Entrez Gene)
EEF1DGeneProduct1936 (Entrez Gene)
EEF1GGeneProduct1937 (Entrez Gene)
EEF2GeneProduct1938 (Entrez Gene)
EEF2KGeneProduct29904 (Entrez Gene)
EIF1AXGeneProduct1964 (Entrez Gene)
EIF1AYGeneProduct9086 (Entrez Gene)
EIF2AK1GeneProduct27102 (Entrez Gene)
EIF2AK2GeneProduct5610 (Entrez Gene) now E2K2 HUMAN
EIF2AK3GeneProduct9451 (Entrez Gene)
EIF2B1GeneProduct1967 (Entrez Gene)
EIF2B2GeneProduct8892 (Entrez Gene)
EIF2B3GeneProduct8891 (Entrez Gene)
EIF2B4GeneProduct8890 (Entrez Gene)
EIF2B5GeneProduct8893 (Entrez Gene)
EIF2S1GeneProduct1965 (Entrez Gene)
EIF2S2GeneProduct8894 (Entrez Gene)
EIF2S3GeneProduct1968 (Entrez Gene)
EIF3S10GeneProduct8661 (Entrez Gene)
EIF3S1GeneProduct8669 (Entrez Gene)
EIF3S2GeneProduct8668 (Entrez Gene)
EIF3S3GeneProduct8667 (Entrez Gene)
EIF3S4GeneProduct8666 (Entrez Gene)
EIF3S5GeneProduct8665 (Entrez Gene)
EIF3S6GeneProduct3646 (Entrez Gene)
EIF3S7GeneProduct8664 (Entrez Gene)
EIF3S8GeneProduct8663 (Entrez Gene)
EIF3S9GeneProduct8662 (Entrez Gene)
EIF4A1GeneProduct1973 (Entrez Gene)
EIF4A2GeneProduct1974 (Entrez Gene)
EIF4BGeneProduct1975 (Entrez Gene)
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
EIF4EBP2GeneProduct1979 (Entrez Gene)
EIF4EBP3GeneProduct8637 (Entrez Gene)
EIF4G1GeneProduct1981 (Entrez Gene) TrEMBL accession number O43177 refers to same protein.
EIF4G3GeneProduct8672 (Entrez Gene)
EIF5GeneProduct1983 (Entrez Gene)
EIF5AGeneProduct1984 (Entrez Gene)
EIF5BGeneProduct9669 (Entrez Gene)
ETF1GeneProduct2107 (Entrez Gene)
GSPT2GeneProduct23708 (Entrez Gene)
ITGB4BPGeneProduct3692 (Entrez Gene)
KIAA0664GeneProduct23277 (Entrez Gene)
PABPC1GeneProduct26986 (Entrez Gene)
PAIP1GeneProduct10605 (Entrez Gene)
SUI1GeneProduct10209 (Entrez Gene)
WBSCR1GeneProduct7458 (Entrez Gene)

Annotated Interactions

No annotated interactions

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