Proteasome degradation (Bos taurus)

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2Ubiquitin/ProteinDeubiquitinates proteinsUnfolds and DegradesIntact ProteinsDegrades only PeptidesOxidatively DamagedCytosolic ProteinsAlpha subunitsLid subunitsPresentation by MHC class 1Ubiquitin/E2 ComplexAMP Ubiquitin/E1 ComplexActivators of20S ComplexProteasome 20SCatalytic Core (p45)Beta subunitsp45 ATPase SubunitE3/ProteinProteins to be DegradedProteasome 26 S(PA700) (ATP dependent)1RPN2UBE2D3PSMD6PSME3JSP.1PSMA1PSMC6UBA7JSP.1PSMD5PSMB4UBE2BPSMB5PSMC5PSMD10UBE2D2PSMA2PSMD13PSMB10PSMD4PSMA7H2AFZJSP.1UbiquitinRPN1PSMD12PSMA4UBBHLA-HPSMA6PSMB8PSMD1PSMB3PSMC1PSMC3PSMD7ATPUBE2D1PSMC5PSMB2UCHL3JSP.1PSMA5UBA1JSP.1PSME2PSMA3PSMB6UCHL1PSME1PSMD2PSMD8JSP.1HIST1H2ABPSMC4IFNGUBCPSMC2PSMB9HLA-JPSMB1H2AFXNEDD4PSMD9PSMD11PSMB7PSMD3


Description

No description

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP183 (r95110) with a 90.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W; ''Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.''; Proc Natl Acad Sci U S A, 2012 PubMed Europe PMC Scholia
  2. Hershko A, Ciechanover A, Varshavsky A; ''Basic Medical Research Award. The ubiquitin system.''; Nat Med, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117056view14:22, 16 May 2021EweitzModified title
95794view14:41, 19 January 2018MkutmonHomology conversion update
80771view15:25, 30 June 2015Mkutmonhomology conversion
71416view19:01, 17 October 2013MaintBotAutomated update of data sources
63376view23:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
62706view23:18, 1 May 2013MaintBotUpdated UniProt data source
58822view23:19, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40548view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33788view00:11, 9 December 2009MaintBotAutomatic update of empty xrefs
32530view12:59, 17 August 2009MaintBotFixed text labels
32217view12:45, 15 August 2009MaintBotFixed text labels
31712view11:52, 14 August 2009MaintBotFixed group labels
31228view19:44, 13 August 2009MaintBotFixed text labels
30648view22:32, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetabolite1927-31-7 (CAS)
H2AFXGeneProductENSBTAG00000038047 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3014
H2AFZGeneProductENSBTAG00000004428 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3015
HIST1H2ABGeneProductNo homologues found for original id L:8335
HLA-HGeneProduct
HLA-JGeneProduct
IFNGGeneProductENSBTAG00000012529 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3458
JSP.1GeneProductENSBTAG00000020116 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3106
NEDD4GeneProductENSBTAG00000013793 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4734
PSMA1GeneProductNo homologues found for original id L:5682
PSMA2GeneProductENSBTAG00000000990 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5683
PSMA3GeneProductENSBTAG00000002808 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5684
PSMA4GeneProductENSBTAG00000014440 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5685
PSMA5GeneProductENSBTAG00000020641 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5686
PSMA6GeneProductENSBTAG00000009683 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5687
PSMA7GeneProductENSBTAG00000005127 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5688
PSMB10GeneProductENSBTAG00000018040 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5699
PSMB1GeneProductENSBTAG00000007685 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5689
PSMB2GeneProductENSBTAG00000002377 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5690
PSMB3GeneProductENSBTAG00000003830 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5691
PSMB4GeneProductENSBTAG00000021288 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5692
PSMB5GeneProductENSBTAG00000012726 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5693
PSMB6GeneProductENSBTAG00000013390 (Ensembl)
  • U13393
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5694
PSMB7GeneProductENSBTAG00000003067 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5695
PSMB8GeneProductENSBTAG00000003039 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5696
PSMB9GeneProductENSBTAG00000008954 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5698
PSMC1GeneProductENSBTAG00000005426 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5700
PSMC2GeneProductENSBTAG00000046712 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5701
PSMC3GeneProductENSBTAG00000021744 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5702
PSMC4GeneProductENSBTAG00000009414 (Ensembl)
  • PRS6 HUMAN
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5704
PSMC5GeneProductENSBTAG00000021061 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5705
PSMC6GeneProductENSBTAG00000015732 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5706
PSMD10GeneProductENSBTAG00000013721 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5716
PSMD11GeneProductENSBTAG00000018897 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5717
PSMD12GeneProductENSBTAG00000002423 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5718
PSMD13GeneProductENSBTAG00000002045 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5719
PSMD1GeneProductENSBTAG00000005119 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5707
PSMD2GeneProductENSBTAG00000005660 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5708
PSMD3GeneProductENSBTAG00000021461 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5709
PSMD4GeneProductENSBTAG00000006101 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5710
PSMD5GeneProductENSBTAG00000016952 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5711
PSMD6GeneProductENSBTAG00000015112 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9861
PSMD7GeneProductENSBTAG00000018425 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5713
PSMD8GeneProductENSBTAG00000031641 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5714
PSMD9GeneProductENSBTAG00000004179 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5715
PSME1GeneProductENSBTAG00000021395 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5720
PSME2GeneProductENSBTAG00000005814 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5721
PSME3GeneProductENSBTAG00000019918 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10197
RPN1GeneProductENSBTAG00000005191 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6184
RPN2GeneProductENSBTAG00000014648 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6185
UBA1GeneProductENSBTAG00000016764 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7317
UBA7GeneProductENSBTAG00000012335 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7318
UBBGeneProductENSBTAG00000017246 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000170315
UBCGeneProductNo homologues found for original id L:7316
UBE2BGeneProductENSBTAG00000010982 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7320
UBE2D1GeneProductENSBTAG00000020796 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7321
UBE2D2GeneProductENSBTAG00000004161 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7322
UBE2D3GeneProductENSBTAG00000048291 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7323
UCHL1GeneProductENSBTAG00000005078 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000154277
UCHL3GeneProductENSBTAG00000008024 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000118939
UbiquitinProteinNo homologues found for original id S:P0CG48

Annotated Interactions

No annotated interactions
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