Cell cycle (Bos taurus)

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1-p+p+pS-phase proteinseG2DNA+p+u+pSCondensinGrowth Factor withdrawalp16,15,18,19p27,57+p+p+p+p+pR-point(start)DNA damage checkpointe+u+p+uSecurinp21+p+peDNAGrowth Factor+p+p+uG1Separin+p+pee+uM+p-pCDC25CTP53Ubiquitin-Mediated ProteolysisCDC7L1RB1E-CADHERINCCNA1UBE2FPKMYT1CDK2BUB3PCNADBF4E2F4CCNA2KITLGAPCRBL1E2F5CHEK1CCNE1E2F2ARF1HDAC6ABL1TBC1D8ATRSMC1ACCNA2CDK1CCNB1HDAC1WEE1CCNB3CCNE2CDK1PRKDCE2F6CDK2TGFB1SMAD4CDC6CDK2EP300CCND2SKP2CCND3BUB1CDKN1AHDAC7MAD1L1BUB1BRB1E2F3GADD45ARBL1PTTG2CDK4MDM2PLK1RB1SMAD3DNA ReplicationTFDP1CCNB2HDAC2SKP2ApoptosisCDKN1BHDAC8KITLGCDC14AHDAC5ESPL1MAPK Signaling PathwayPTTG3E2F1CHEK2MPEG1GSK3BCDC14BCDC45LCDC20MD2L1MCM2YWHAGPTTG1ATMYWHAGCDC25ACCNHCDK6CDC25BHDAC4HDAC3MEN1MAD2L2CCNA1CDKN2AAPCYWHABYWHAEYWHAHYWHAQYWHAZMCM3MCM4MCM5MCM6MCM7MCM8MCM9MCM10ORC1ORC2ORC3ORC4ORC5LORC6


Description

The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.


Sources: Wikipedia:Cell cycle, KEGG

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP179(70629) with a 99.0% conversion rate.

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Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120485view09:24, 8 December 2021EgonwMade four pathways clickable
117485view11:00, 21 May 2021EweitzModified title
115732view09:39, 9 March 2021EgonwReplaced the WP id of a human pathways with the matching cow pathway
89450view12:59, 15 September 2016Mkutmonremove space in ontology term id
80905view15:30, 30 June 2015Mkutmonhomology conversion
71398view19:00, 17 October 2013MaintBotAutomated update of data sources
63321view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
62702view23:16, 1 May 2013MaintBotUpdated UniProt data source
40502view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35374view09:16, 12 February 2010MartijnVanIerselModified description
33745view23:57, 8 December 2009MaintBotAutomatic update of empty xrefs
32533view13:00, 17 August 2009MaintBotFixed text labels
32220view12:46, 15 August 2009MaintBotFixed text labels
31716view11:53, 14 August 2009MaintBotFixed group labels
31231view19:44, 13 August 2009MaintBotFixed text labels
30652view22:33, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProductENSBTAG00000017976 (Ensembl)
  • ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25
APCGeneProductENSBTAG00000018852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
ARF1GeneProductENSBTAG00000007725 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:375
ATMGeneProductENSBTAG00000003111 (Ensembl)
  • ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:472
ATRGeneProductENSBTAG00000011529 (Ensembl)
  • ATR; ataxia telangiectasia and Rad3 related
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:545
ApoptosisPathwayWP254 (WikiPathways)
BUB1BGeneProductENSBTAG00000007237 (Ensembl)
  • BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:701
BUB1GeneProductENSBTAG00000021181 (Ensembl)
  • BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:699
BUB3GeneProductENSBTAG00000017913 (Ensembl)
  • BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9184
CCNA1GeneProductENSBTAG00000007284 (Ensembl)
  • CCNA1; cyclin A1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8900
CCNA2GeneProductENSBTAG00000004943 (Ensembl)
  • CCNA2; cyclin A2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:890
CCNB1GeneProductENSBTAG00000014239 (Ensembl)
  • CCNB1; cyclin B1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:891
CCNB2GeneProductENSBTAG00000005269 (Ensembl)
  • CCNB2; cyclin B2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9133
CCNB3GeneProductENSBTAG00000046286 (Ensembl)
  • CCNB3; cyclin B
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85417
CCND2GeneProductENSBTAG00000016649 (Ensembl)
  • CCND2; cyclin D2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894
CCND3GeneProductENSBTAG00000010106 (Ensembl)
  • CCND3; cyclin D3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
CCNE1GeneProductENSBTAG00000004735 (Ensembl)
  • CCNE1; cyclin E
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:898
CCNE2GeneProductENSBTAG00000004906 (Ensembl)
  • CCNE2; cyclin E
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9134
CCNHGeneProductENSBTAG00000009566 (Ensembl)
  • CCNH; cyclin H
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:902
CDC14AGeneProductENSBTAG00000031439 (Ensembl)
  • CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8556
CDC14BGeneProductENSBTAG00000011589 (Ensembl)
  • CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8555
CDC20GeneProductENSBTAG00000009819 (Ensembl)
  • CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:991
CDC25AGeneProductENSBTAG00000009586 (Ensembl)
  • CDC25A; cell division cycle 25A [EC:3.1.3.48]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:993
CDC25BGeneProductENSBTAG00000008436 (Ensembl)
  • CDC25B; cell division cycle 25B [EC:3.1.3.48]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:994
CDC25CGeneProductENSBTAG00000005293 (Ensembl)
  • CDC25C; cell division cycle 25C [EC:3.1.3.48]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:995
CDC45LGeneProductENSBTAG00000004286 (Ensembl)
  • CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8318
CDC6GeneProductENSBTAG00000010384 (Ensembl)
  • CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:990
CDC7L1GeneProductENSBTAG00000016307 (Ensembl)
  • CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8317
CDK1GeneProductENSBTAG00000010109 (Ensembl)
  • CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:983
CDK2GeneProductENSBTAG00000004021 (Ensembl)
  • CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
CDK4GeneProductENSBTAG00000046091 (Ensembl)
  • CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1019
CDK6GeneProductENSBTAG00000044023 (Ensembl)
  • CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1021
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CDKN1BGeneProductENSBTAG00000018254 (Ensembl)
  • CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
CDKN2AGeneProductENSBTAG00000034220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
CHEK1GeneProductENSBTAG00000017582 (Ensembl)
  • CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1111
CHEK2GeneProductENSBTAG00000004956 (Ensembl)
  • CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11200
DBF4GeneProductENSBTAG00000014711 (Ensembl)
  • ASK; activator of S phase kinas
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10926
DNA ReplicationPathwayWP466 (WikiPathways)
E-CADHERINGeneProductENSBTAG00000015991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:999
E2F1GeneProductENSBTAG00000003971 (Ensembl)
  • E2F1; E2F transcription factor 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
E2F2GeneProductENSBTAG00000014400 (Ensembl)
  • E2F2; E2F transcription factor 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1870
E2F3GeneProductENSBTAG00000021045 (Ensembl)
  • E2F3; E2F transcription factor 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1871
E2F4GeneProductENSBTAG00000012063 (Ensembl)
  • E2F4; E2F transcription factor 4 p107/p130-binding
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1874
E2F5GeneProductENSBTAG00000009378 (Ensembl)
  • E2F5; E2F transcription factor 5 p130-binding
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1875
E2F6GeneProductENSBTAG00000048286 (Ensembl)
  • E2F6; E2F transcription factor 6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1876
EP300GeneProductENSBTAG00000016198 (Ensembl)
  • EP300; E1A binding protein p300
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
ESPL1GeneProductENSBTAG00000008934 (Ensembl)
  • ESPL1; extra spindle poles like 1 (S. cerevisiae
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9700
GADD45AGeneProductENSBTAG00000013860 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1647
GSK3BGeneProductENSBTAG00000048057 (Ensembl)
  • GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
HDAC1GeneProductENSBTAG00000012698 (Ensembl)
  • HDAC1; histone deacetylase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3065
HDAC2GeneProductENSBTAG00000011849 (Ensembl)
  • HDAC2; histone deacetylase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3066
HDAC3GeneProductENSBTAG00000017360 (Ensembl)
  • HDAC3; histone deacetylase 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8841
HDAC4GeneProductENSBTAG00000017764 (Ensembl)
  • HDAC4; histone deacetylase 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9759
HDAC5GeneProductENSBTAG00000016254 (Ensembl)
  • HDAC5; histone deacetylase 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10014
HDAC6GeneProductENSBTAG00000013244 (Ensembl)
  • HDAC6; histone deacetylase 6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10013
HDAC7GeneProductENSBTAG00000026819 (Ensembl)
  • HDAC7A; histone deacetylase 7
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51564
HDAC8GeneProductENSBTAG00000046092 (Ensembl)
  • HDAC8; histone deacetylase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55869
KITLGGeneProductENSBTAG00000017549 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4254
MAD1L1GeneProductENSBTAG00000002474 (Ensembl)
  • MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8379
MAD2L2GeneProductENSBTAG00000013275 (Ensembl)
  • MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10459
MAPK Signaling PathwayPathwayWP382 (WikiPathways)
MCM10GeneProductENSBTAG00000016406 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55388
MCM2GeneProductENSBTAG00000014380 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4171
MCM3GeneProductENSBTAG00000010721 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4172
MCM4GeneProductENSBTAG00000017021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4173
MCM5GeneProductENSBTAG00000015595 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4174
MCM6GeneProductENSBTAG00000015172 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4175
MCM7GeneProductENSBTAG00000030965 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4176
MCM8GeneProductENSBTAG00000014623 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84515
MCM9GeneProductENSBTAG00000002059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:254394
MD2L1GeneProductENSBTAG00000035319 (Ensembl)
  • MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4085
MDM2GeneProductENSBTAG00000010422 (Ensembl)
  • MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193
MEN1GeneProductENSBTAG00000002095 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4221
MPEG1GeneProductENSBTAG00000045939 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:219972
ORC1GeneProductENSBTAG00000002719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4998
ORC2GeneProductENSBTAG00000031473 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4999
ORC3GeneProductENSBTAG00000016969 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23595
ORC4GeneProductENSBTAG00000015291 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5000
ORC5LGeneProductENSBTAG00000040058 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5001
ORC6GeneProductENSBTAG00000001872 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23594
PCNAGeneProductENSBTAG00000006065 (Ensembl)
  • PCNA; proliferating cell nuclear antigen
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111
PKMYT1GeneProductENSBTAG00000004729 (Ensembl)
  • PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9088
PLK1GeneProductENSBTAG00000014453 (Ensembl)
  • PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5347
PRKDCGeneProductENSBTAG00000017019 (Ensembl)
  • PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5591
PTTG1GeneProductENSBTAG00000047322 (Ensembl)
  • PTTG1; pituitary tumor-transforming
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9232
PTTG2GeneProductENSBTAG00000047322 (Ensembl)
  • PTTG2; pituitary tumor-transforming
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10744
PTTG3GeneProductPTTG3; pituitary tumor-transforming
RB1GeneProductENSBTAG00000006640 (Ensembl)
  • RB1; retinoblastoma 1 (including osteosarcoma)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
RBL1GeneProductENSBTAG00000011541 (Ensembl)
  • RBL1; retinoblastoma-like 1 (p107)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5933
SKP2GeneProductENSBTAG00000013562 (Ensembl)
  • SKP2; S-phase kinase-associated protein 2 (p45
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6502
SMAD3GeneProductENSBTAG00000012599 (Ensembl)
  • MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088
SMAD4GeneProductENSBTAG00000006919 (Ensembl)
  • MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
SMC1AGeneProductENSBTAG00000017761 (Ensembl)
  • SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8243
TBC1D8GeneProductENSBTAG00000025898 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11138
TFDP1GeneProductENSBTAG00000019645 (Ensembl)
  • TFDP1; transcription factor Dp-1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7027
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
UBE2FGeneProductENSBTAG00000026114 (Ensembl)
  • UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:140739
Ubiquitin-Mediated ProteolysisPathwayWP1079 (WikiPathways)
WEE1GeneProductENSBTAG00000005278 (Ensembl)
  • WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7465
YWHABGeneProductENSBTAG00000016846 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7529
YWHAEGeneProductENSBTAG00000005664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7531
YWHAGGeneProductENSBTAG00000004077 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7532
YWHAHGeneProductENSBTAG00000011631 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7533
YWHAQGeneProductENSBTAG00000002108 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10971
YWHAZGeneProductENSBTAG00000000236 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7534

Annotated Interactions

No annotated interactions
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