Insulin signaling (Canis familiaris)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Insulin Receptor SubstratesSHC3IRS1IRS2SHC1IRS4IRS3SHC2GAB1PDK/Akt SignalingGSK3BAKT2AKT1SGKLSGK1GSK3APDPK1SGK2Glucose TransportMetabolic RegulationTor SignalingCell GrowthDifferentiationModulators of Insulin ActionTranscriptional Regulators & Immediate Early GenesSRFELK1FOXO1FOSJUNFOXO3EGR1MEK/MAP KinasesMINK1MAP4K4MAP3K2MAPK12MAP3K5MAPK10MAP3K3MAP4K1MAPK3MAP2K7MAPK13MAP3K1MAP4K3MAP2K6MAP3K8MAP3K12MAP2K4MAPK7MAPK14MAP3K11MAP3K7MAPK11MAPK9MAPK6MAP3K13MAP2K3MAPK4MAP4K2MAP2K5MAP3K10MAPK1MAP2K1MAP3K6MAP3K4MAP3K9MAP4K5MAP2K2MAPK8MAP3K14Vesicular TraffickingSTXBP2CYTH3LOC100855651EHD2ARF6RAB4ACAP1STXBP1CRKSTXBP4TBC1D4SH2B2EHD1ARHGAP33STX4SNAP25RHOQSNAP23CBLBSTXBP3CBLLOC100856195CBLCLOC100855443RHOJSORBS1LOC480487RAPGEF1VAMP2FLOT1KIF3Ap70 S6 KinasesRPS6KB2RPS6KB1p90 Rsk KinasesRPS6KA4RPS6KA3RPS6KA6RPS6KA5RPS6KA1RPS6KA2PI 3-Kinase isoformsPIK3CDPIK3C3LOC100856339PIK3R1PIK3C2GPIK3R2PIK3CGPIK3CBPIK3R4PIK3C2APIK3CATranslation RegulationEIF4EBP1EIF4ERas-MAPK SignalingRAC1GRB2SOS1RAC2RRADGRB14SOS2RAF1H-RASGRB10PTPSLC2A1RHEBINSRSLC2A4IGF1RMTORPRKCHPRKCDTRIB3PRKCBPRKCZPRKCQPRKAA2PRKCIPRKAA1PRKCAGYG1PFKMGYS1PFKLGYS2PPP1R3ALIPEPTPRFIKBKBSOCS3PTENXBP1LOC100856150PTPN1MAPK8INPPL1INPP4APTPN11SOCS1TSC2TSC1IRS1PIK3Name: Insulin signalingOrganism: Canis familiaris


Description

Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP481(r45380) with a 95% conversion rate.

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Quality Tags

Image:Unconnected.pngFix interactions
Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

 

Bibliography

  1. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed Europe PMC Scholia
  2. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed Europe PMC Scholia
  3. Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129527view01:16, 9 May 2024EweitzModified title
125471
Homology Converted
view13:29, 16 February 2023Mkutmonfix complexes
125470view13:28, 16 February 2023Mkutmonfix complexes and unconnected lines
125469view13:08, 16 February 2023EgonwRemoved the Last-Modified attribute
68506view21:50, 5 July 2013MaintBotUpdated to 2013 gpml schema
48159view18:56, 9 May 2012MaintBotUpdating from human to fix xrefs
40657view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
33949view18:20, 9 December 2009MaintBotAutomatic update of empty xrefs
32535view13:01, 17 August 2009MaintBotFixed text labels
32222view12:46, 15 August 2009MaintBotFixed text labels
31718view11:54, 14 August 2009MaintBotFixed group labels
31233view19:45, 13 August 2009MaintBotFixed text labels
30654view22:34, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  â†“Type  â†“Database reference  â†“Comment  â†“
AKT1GeneProduct490878 (Entrez Gene)
AKT2GeneProduct449021 (Entrez Gene)
ARF6GeneProduct490679 (Entrez Gene)
ARHGAP33GeneProduct484573 (Entrez Gene)
CAP1GeneProduct475317 (Entrez Gene)
CBLGeneProduct489369 (Entrez Gene)
CBLBGeneProduct487965 (Entrez Gene)
CBLCGeneProduct612343 (Entrez Gene)
CRKGeneProduct100684309 (Entrez Gene)
CYTH3GeneProduct609100 (Entrez Gene)
EGR1GeneProduct481528 (Entrez Gene)
EHD1GeneProduct100685675 (Entrez Gene)
EHD2GeneProduct484417 (Entrez Gene)
EIF4EGeneProduct487870 (Entrez Gene)
EIF4EBP1GeneProduct475590 (Entrez Gene)
ELK1GeneProduct491860 (Entrez Gene)
FLOT1GeneProduct474831 (Entrez Gene)
FOSGeneProduct490792 (Entrez Gene)
FOXO1GeneProduct477295 (Entrez Gene)
FOXO3GeneProduct481954 (Entrez Gene)
GAB1GeneProduct483808 (Entrez Gene)
GRB10GeneProduct607755 (Entrez Gene)
GRB14GeneProduct478770 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
GSK3AGeneProduct484476 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene)
GYG1GeneProduct611614 (Entrez Gene)
GYS1GeneProduct611993 (Entrez Gene)
GYS2GeneProduct403737 (Entrez Gene)
H-RASGeneProduct403735 (Entrez Gene)
IGF1RGeneProduct442951 (Entrez Gene)
IKBKBGeneProduct482839 (Entrez Gene)
INPP4AGeneProduct474563 (Entrez Gene)
INPPL1GeneProduct485209 (Entrez Gene)
INSRGeneProduct484990 (Entrez Gene)
IRS1GeneProduct486148 (Entrez Gene)
IRS2GeneProduct485548 (Entrez Gene)
IRS3GeneProduct
IRS4GeneProduct492059 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
KIF3AGeneProduct474675 (Entrez Gene)
LIPEGeneProduct403607 (Entrez Gene)
LOC100855443GeneProduct100855443 (Entrez Gene)
LOC100855651GeneProduct100855651 (Entrez Gene)
LOC100856150GeneProduct100856150 (Entrez Gene)
LOC100856195GeneProduct100856195 (Entrez Gene)
LOC100856339GeneProduct100856339 (Entrez Gene)
LOC480487GeneProduct480487 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K2GeneProduct611939 (Entrez Gene)
MAP2K3GeneProduct489547 (Entrez Gene)
MAP2K4GeneProduct
MAP2K5GeneProduct609559 (Entrez Gene)
MAP2K6GeneProduct480454 (Entrez Gene)
MAP2K7GeneProduct485004 (Entrez Gene)
MAP3K10GeneProduct484504 (Entrez Gene)
MAP3K11GeneProduct483732 (Entrez Gene)
MAP3K12GeneProduct607170 (Entrez Gene)
MAP3K13GeneProduct100685499 (Entrez Gene)
MAP3K14GeneProduct490926 (Entrez Gene)
MAP3K1GeneProduct478061 (Entrez Gene)
MAP3K2GeneProduct612902 (Entrez Gene)
MAP3K3GeneProduct480481 (Entrez Gene)
MAP3K4GeneProduct476262 (Entrez Gene)
MAP3K5GeneProduct476215 (Entrez Gene)
MAP3K6GeneProduct487345 (Entrez Gene)
MAP3K7GeneProduct
MAP3K8GeneProduct487085 (Entrez Gene)
MAP3K9GeneProduct490765 (Entrez Gene)
MAP4K1GeneProduct484527 (Entrez Gene)
MAP4K2GeneProduct483759 (Entrez Gene)
MAP4K3GeneProduct475734 (Entrez Gene)
MAP4K4GeneProduct481331 (Entrez Gene)
MAP4K5GeneProduct490685 (Entrez Gene)
MAPK10GeneProduct478464 (Entrez Gene)
MAPK11GeneProduct607019 (Entrez Gene)
MAPK12GeneProduct607023 (Entrez Gene)
MAPK13GeneProduct612821 (Entrez Gene)
MAPK14GeneProduct403856 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct479790 (Entrez Gene)
MAPK4GeneProduct491690 (Entrez Gene)
MAPK6GeneProduct478311 (Entrez Gene)
MAPK7GeneProduct489532 (Entrez Gene)
MAPK8GeneProduct477746 (Entrez Gene)
MAPK9GeneProduct474652 (Entrez Gene)
MINK1GeneProduct100686834 (Entrez Gene)
MTORGeneProduct478232 (Entrez Gene)
PDPK1GeneProduct479875 (Entrez Gene)
PFKLGeneProduct487797 (Entrez Gene)
PFKMGeneProduct403849 (Entrez Gene)
PIK3GeneProduct
PIK3C2AGeneProduct485399 (Entrez Gene)
PIK3C2GGeneProduct477681 (Entrez Gene)
PIK3C3GeneProduct490477 (Entrez Gene)
PIK3CAGeneProduct488084 (Entrez Gene)
PIK3CBGeneProduct477085 (Entrez Gene)
PIK3CDGeneProduct489644 (Entrez Gene)
PIK3CGGeneProduct483266 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
PIK3R4GeneProduct477064 (Entrez Gene)
PPP1R3AGeneProduct482411 (Entrez Gene)
PRKAA1GeneProduct479351 (Entrez Gene)
PRKAA2GeneProduct489571 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PRKCDGeneProduct494005 (Entrez Gene)
PRKCHGeneProduct490722 (Entrez Gene)
PRKCIGeneProduct478686 (Entrez Gene)
PRKCQGeneProduct478013 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PTENGeneProduct403832 (Entrez Gene)
PTPGeneProduct
PTPN11GeneProduct477488 (Entrez Gene)
PTPN1GeneProduct477263 (Entrez Gene)
PTPRFGeneProduct475389 (Entrez Gene)
RAB4AGeneProduct479210 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RAC2GeneProduct481271 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RAPGEF1GeneProduct491286 (Entrez Gene)
RHEBGeneProduct475545 (Entrez Gene)
RHOJGeneProduct612985 (Entrez Gene)
RHOQGeneProduct474579 (Entrez Gene)
RPS6KA1GeneProduct487353 (Entrez Gene)
RPS6KA2GeneProduct612448 (Entrez Gene)
RPS6KA3GeneProduct491768 (Entrez Gene)
RPS6KA4GeneProduct612105 (Entrez Gene)
RPS6KA5GeneProduct490831 (Entrez Gene)
RPS6KA6GeneProduct491989 (Entrez Gene)
RPS6KB1GeneProduct480580 (Entrez Gene)
RPS6KB2GeneProduct610499 (Entrez Gene)
RRADGeneProduct611304 (Entrez Gene)
SGK1GeneProduct403647 (Entrez Gene)
SGK2GeneProduct610835 (Entrez Gene)
SGKLGeneProduct
SH2B2GeneProduct489820 (Entrez Gene)
SHC1GeneProduct490439 (Entrez Gene)
SHC2GeneProduct611955 (Entrez Gene)
SHC3GeneProduct
SLC2A1GeneProduct482437 (Entrez Gene)
SLC2A4GeneProduct403673 (Entrez Gene)
SNAP23GeneProduct478268 (Entrez Gene)
SNAP25GeneProduct477158 (Entrez Gene)
SOCS1GeneProduct490006 (Entrez Gene)
SOCS3GeneProduct442949 (Entrez Gene)
SORBS1GeneProduct100686806 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene)
SOS2GeneProduct490682 (Entrez Gene)
SRFGeneProduct612861 (Entrez Gene)
STX4GeneProduct489919 (Entrez Gene)
STXBP1GeneProduct609241 (Entrez Gene)
STXBP2GeneProduct403880 (Entrez Gene)
STXBP3GeneProduct490128 (Entrez Gene)
STXBP4GeneProduct491094 (Entrez Gene)
TBC1D4GeneProduct485494 (Entrez Gene)
TRIB3GeneProduct485819 (Entrez Gene)
TSC1GeneProduct480688 (Entrez Gene)
TSC2GeneProduct479883 (Entrez Gene)
VAMP2GeneProduct479491 (Entrez Gene)
XBP1GeneProduct477532 (Entrez Gene)

Annotated Interactions

No annotated interactions
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