Hypothetical network for drug addiction (Canis familiaris)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Strong depolarizationNeuroactive ligand-receptorinteractionRegulation of gap junctionGap junctionGonadotropins gene expression & secretionMAPK signaling pathwayGnRH Signal pathwayLong-term potentiationRegulation of actin cytoskeletonLocal TranslationNMDARGRIN2CGRIN2DGRIN2BGRIN2AGRIN1mGluRGRM5GRM1AMPARGRIA1GRIA4GRIA3GRIA2CAMK4PPA1ZHX2DRD4TERF2IPKRIT1PRKCEACTA1ADCY1NISCHCyclic AMPDRD2Ca++GsDRD1D-GlutamateCREB1CAMK2PRKACAGiPRKACAAC1ADCY8MAPK3MAPK1MAP2K2MAP2K1connexinconnexinName: Hypothetical network for drug addictionOrganism: Canis familiaris


Description

Adapted from figure 2 in Li et al..

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP666(r29740) with a 75% conversion rate.

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Quality Tags

Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

Pathway Ontology : metabolic disease pathway
 

Bibliography

  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118083view10:44, 24 May 2021EweitzModified title
107086view14:17, 17 September 2019MaintBotChEBI identifier normalization
102909view11:10, 28 January 2019EgonwFixed the ChEBI identifier for Ca2+
88656view15:14, 12 August 2016JmeliusOntology Term : 'substance dependence disease pathway' added !
68502view21:46, 5 July 2013MaintBotUpdated to 2013 gpml schema
40653view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
33946view18:19, 9 December 2009MaintBotAutomatic update of empty xrefs
32548view13:05, 17 August 2009MaintBotFixed text labels
32229view12:49, 15 August 2009MaintBotFixed text labels
31733view11:58, 14 August 2009MaintBotFixed group labels
31246view19:50, 13 August 2009MaintBotFixed text labels
30677view22:42, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AC1GeneProduct
ACTA1GeneProduct403580 (Entrez Gene)
ADCY1GeneProduct
ADCY8GeneProduct482045 (Entrez Gene)
CAMK2GeneProduct
CAMK4GeneProduct
CREB1GeneProduct607922 (Entrez Gene)
Ca++MetaboliteCHEBI:29108 (ChEBI)
Cyclic AMPMetaboliteCHEBI:17489 (ChEBI)
D-GlutamateMetaboliteCHEBI:15966 (ChEBI)
DRD1GeneProduct489110 (Entrez Gene)
DRD2GeneProduct403701 (Entrez Gene)
DRD4GeneProduct448805 (Entrez Gene)
GRIA1GeneProduct489168 (Entrez Gene)
GRIA2GeneProduct482667 (Entrez Gene)
GRIA3GeneProduct492110 (Entrez Gene)
GRIA4GeneProduct489427 (Entrez Gene)
GRIN1GeneProduct494007 (Entrez Gene)
GRIN2AGeneProduct490012 (Entrez Gene)
GRIN2BGeneProduct494009 (Entrez Gene)
GRIN2CGeneProduct483302 (Entrez Gene)
GRIN2DGeneProduct484405 (Entrez Gene)
GRM1GeneProduct484024 (Entrez Gene)
GRM5GeneProduct485146 (Entrez Gene)
GiGeneProduct
GsGeneProduct
KRIT1GeneProduct482299 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K2GeneProduct611939 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
NISCHGeneProduct476594 (Entrez Gene)
PPA1GeneProduct479238 (Entrez Gene)
PRKACAGeneProduct403556 (Entrez Gene)
PRKCEGeneProduct609934 (Entrez Gene)
TERF2IPGeneProduct479643 (Entrez Gene)
ZHX2GeneProduct482033 (Entrez Gene)
connexinGeneProduct

Annotated Interactions

No annotated interactions
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