Transforming growth factor (TGF) beta receptor signaling (Canis familiaris)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NU -> CYNU -> CYNUCYCYNUCYNUNUCYNUCYNUCYNUCYNUCYCYNUCYNUCYNUCYNUCYNUCYNUNUCYNUCYCYNUNUCYNUCYCYNUCYNUNUCYNUCYNUCYNUCYCYNUReceptorLigandMolecule in the pathwayProteins in a complex interactionEnzyme complexMolecular association(Protein-protein interaction)DReaction through unknown mechanisms/moleculesAutophosphorylationAcetylationDeacetylationGlycosylationGlycosylationMethylationDemethylationPalmitoylationPhosphorylationDephosphorylationProteolytic cleavageSumoylationDesumoylationUbiquitinationDeubiquitinationActivationInhibitionRecruitmentControlTranslocationCYCytoplasmECExtracellularENEndosomeEREndoplasmic reticulumGOGolgi apparatusMTMitochondriaNUNucleusPMPlasma membraneAccession Number: NetPath 7; cellmap: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 SymbolACVRL1Name: Transforming growth factor (TGF) beta receptor signalingOrganism: Canis familiaris


Description

No description

Comments

GenMAPP notes 
NetPath 7; cellmap:7 - TGF-beta Receptor Signaling Pathway

The TGF-beta Receptor Signaling pathway was kindly reviewed by Van Le Hong, Wei He and other members of Joan Massague’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP366(r21445) with a 92% conversion rate.

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Quality Tags

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Homology Converted

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
129684view00:46, 22 May 2024EweitzModified title
118020view11:36, 23 May 2021EweitzModified title
87756view09:56, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87754view09:56, 25 July 2016MirellaKalafatiModified title
87753view09:55, 25 July 2016MirellaKalafatiModified title
68533view22:17, 5 July 2013MaintBotUpdated to 2013 gpml schema
40689view21:50, 1 March 2011MaintBotRemoved redundant pathway information and comments
33975view18:29, 9 December 2009MaintBotAutomatic update of empty xrefs
31279view20:01, 13 August 2009MaintBotFixed text labels
30730view22:59, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  â†“Type  â†“Database reference  â†“Comment  â†“
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CAMK2BGeneProduct
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CDKN1AGeneProduct474890 (Entrez Gene)
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PPP2R2AGeneProduct477374 (Entrez Gene)
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PRKCDGeneProduct494005 (Entrez Gene)
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RB1GeneProduct476915 (Entrez Gene)
RBL1GeneProduct477221 (Entrez Gene)
RBL2GeneProduct478127 (Entrez Gene)
RBX1GeneProduct474494 (Entrez Gene)
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TGFB3GeneProduct490796 (Entrez Gene)
TGFBR1GeneProduct481628 (Entrez Gene)
TGFBR2GeneProduct477039 (Entrez Gene)
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TGIFGeneProduct
TP53GeneProduct403869 (Entrez Gene)
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UBE2D3GeneProduct
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ZFYVE9GeneProduct475352 (Entrez Gene)

Annotated Interactions

No annotated interactions
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