Cell cycle (Canis familiaris)

From WikiPathways

Jump to: navigation, search
1e+u-pp16,15,18,19+pDNAp21Securinpathway+pTranscription Factor E2FGrowth Factor withdrawalmediated+p+p+p(Start)G2e+pMeDNA biosynthesisMCM (Mini-ChromosomeMaintenance) complexCondensin+peeS-phase proteinsUbiquitinSeparinMAPKApoptosis+p+pHDAC+pG1DNAGrowth Factor+p+p+u+p+pproteolysisDNA damage checkpointsignalingSR-point+up27,57+pHistone Deacetylases+u-pORC (OriginRecognition complex)+u+p+pMPEG1RBL1ORC5LCCNA2CCNA2CDK4CHEK2APC/CCDK2CDKN1BPCNARB1E2FSKP2BUB1BLOC478040MCM6CCNA1CDC6CCNB2BUB3ARFATMMCM514-3-3SCFORCLOC486589GSK3BSMAD3LOC480907MCM7PTTG1PTTG2ATRUBE2FMAD2L1SMAD4CCNE2CDK2E2F1E2F3CDC25BSMC1ACCND3CDC2PRKDCDBF4ORC3LESPL1LOC607662CDK6SKP2MDM2MCM2CCNB3YWHAGORC4LTP53CCNB1CDC45LCDKN1ABUB1CCNE1MAD1L1CDC7CDC14ACDH1E2F2ORC2LPKMYT1WEE1LOC487309LOC475035TGFB1CCNHCDC25ARB1CDC2GeneProductCDC14BMCM3MAD2L2ABL1CDK2ORC6LLOC490941CCND2RBL1E2F6TFDP1E2F4GADD45ASCFMCM4CCNA1CDKN2AE2F5MENPTTG3MCMTBC1D8RB1CDC20APC/CLOC480957CDC25CORC1LEP300CHEK1PLK1


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP179(r30295) with a 80% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
111030view21:36, 1 July 2020L DupuisConverted interactions to graphical lines in outlines
86993view14:38, 15 July 2016MkutmonOntology Term : 'cell cycle pathway' added !
71456view19:16, 17 October 2013MaintBotAutomated update of data sources
68515view21:59, 5 July 2013MaintBotUpdated to 2013 gpml schema
62716view03:16, 2 May 2013MaintBotUpdated UniProt data source
40668view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
35372view09:16, 12 February 2010MartijnVanIerselModified description
33960view18:24, 9 December 2009MaintBotAutomatic update of empty xrefs
32275view13:06, 15 August 2009MaintBotFixed text labels
31810view12:21, 14 August 2009MaintBotFixed group labels
31303view20:11, 13 August 2009MaintBotFixed text labels
30769view23:15, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-3-3GeneProduct
ABL1GeneProduct491292 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
APC/CGeneProduct
ARFGeneProduct
ATMGeneProduct479450 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
ATRGeneProduct477101 (Entrez Gene) ATR; ataxia telangiectasia and Rad3 related
BUB1GeneProductBUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
BUB1BGeneProduct608350 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
BUB3GeneProduct477857 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CCNA1GeneProduct477302 (Entrez Gene) CCNA1; cyclin A1
CCNA2GeneProduct483845 (Entrez Gene) CCNA2; cyclin A2
CCNB1GeneProductCCNB1; cyclin B1
CCNB2GeneProduct478324 (Entrez Gene) CCNB2; cyclin B2
CCNB3GeneProduct449494 (Entrez Gene) CCNB3; cyclin B
CCND2GeneProduct611782 (Entrez Gene) CCND2; cyclin D2
CCND3GeneProduct608847 (Entrez Gene) CCND3; cyclin D3
CCNE1GeneProduct484610 (Entrez Gene) CCNE1; cyclin E
CCNE2GeneProduct487057 (Entrez Gene) CCNE2; cyclin E
CCNHGeneProduct479156 (Entrez Gene) CCNH; cyclin H
CDC14AGeneProduct479926 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
CDC14BGeneProduct476294 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CDC20GeneProduct482534 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CDC2GeneProduct488997 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
CDC25AGeneProduct484780 (Entrez Gene) CDC25A; cell division cycle 25A [EC:3.1.3.48]
CDC25BGeneProduct485790 (Entrez Gene) CDC25B; cell division cycle 25B [EC:3.1.3.48]
CDC25CGeneProduct610456 (Entrez Gene) CDC25C; cell division cycle 25C [EC:3.1.3.48]
CDC45LGeneProduct486421 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CDC6GeneProduct480527 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
CDC7GeneProduct479955 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDH1GeneProduct442858 (Entrez Gene)
CDK2GeneProduct606931 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProduct481131 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6GeneProduct609920 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDKN1AGeneProduct474890 (Entrez Gene)
CDKN1BGeneProduct403429 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2AGeneProduct100271861 (Entrez Gene)
CHEK1GeneProduct609767 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CHEK2GeneProduct486338 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
DBF4GeneProduct475219 (Entrez Gene) ASK; activator of S phase kinas
E2FGeneProduct
E2F1GeneProduct485839 (Entrez Gene) E2F1; E2F transcription factor 1
E2F2GeneProductE2F2; E2F transcription factor 2
E2F3GeneProduct488239 (Entrez Gene) E2F3; E2F transcription factor 3
E2F4GeneProduct611243 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
E2F5GeneProduct611103 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
E2F6GeneProduct609996 (Entrez Gene) E2F6; E2F transcription factor 6
EP300GeneProductEP300; E1A binding protein p300
ESPL1GeneProduct607879 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
GADD45AGeneProduct
GSK3BGeneProduct478575 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
GeneProductGeneProduct
LOC475035GeneProduct475035 (Entrez Gene) HDAC2; histone deacetylase 2
LOC478040GeneProduct478040 (Entrez Gene) HDAC3; histone deacetylase 3
LOC480907GeneProduct480907 (Entrez Gene) HDAC6; histone deacetylase 6
LOC480957GeneProduct480957 (Entrez Gene) HDAC8; histone deacetylase
LOC486589GeneProduct486589 (Entrez Gene) HDAC7A; histone deacetylase 7
LOC487309GeneProduct487309 (Entrez Gene) HDAC1; histone deacetylase 1
LOC490941GeneProduct490941 (Entrez Gene) HDAC5; histone deacetylase 5
LOC607662GeneProduct607662 (Entrez Gene) HDAC4; histone deacetylase 4
MAD1L1GeneProduct609673 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MAD2L1GeneProduct476070 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L2GeneProduct487443 (Entrez Gene) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MCMGeneProduct
MCM2GeneProduct484622 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
MCM3GeneProduct481839 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
MCM4GeneProduct477871 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
MCM5GeneProduct610519 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
MCM6GeneProduct476131 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
MCM7GeneProduct479737 (Entrez Gene) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
MDM2GeneProduct403693 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MENGeneProduct
MPEG1GeneProduct475960 (Entrez Gene)
ORCGeneProduct
ORC1LGeneProduct475351 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
ORC2LGeneProduct478868 (Entrez Gene) ORC2L; origin recognition complex subunit 2-like (yeast)
ORC3LGeneProduct474991 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
ORC4LGeneProduct476141 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)
ORC5LGeneProduct609937 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
ORC6LGeneProduct482492 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
PCNAGeneProduct477166 (Entrez Gene) PCNA; proliferating cell nuclear antigen
PKMYT1GeneProduct490050 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
PLK1GeneProduct489971 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PRKDCGeneProduct474176 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
PTTG1GeneProduct479307 (Entrez Gene) PTTG1; pituitary tumor-transforming
PTTG2GeneProductPTTG2; pituitary tumor-transforming
PTTG3GeneProductPTTG3; pituitary tumor-transforming
RB1GeneProduct476915 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
RBL1GeneProduct477221 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
SCFGeneProduct
SKP2GeneProduct489228 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
SMAD3GeneProduct610902 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD4GeneProduct476196 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
SMC1AGeneProduct480928 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TBC1D8GeneProduct474551 (Entrez Gene)
TFDP1GeneProduct607720 (Entrez Gene) TFDP1; transcription factor Dp-1
TGFB1GeneProduct403998 (Entrez Gene)
TP53GeneProduct403869 (Entrez Gene)
UBE2FGeneProduct477421 (Entrez Gene) UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
WEE1GeneProduct476847 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
YWHAGGeneProduct489818 (Entrez Gene) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid

Annotated Interactions

No annotated interactions
Personal tools