Methylation (Equus caballus)

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1, 2S-methylationO-methylationSAM synthesis (co-substrate)N-methylationS-AdenosylhomocysteineS-AdenosylmethionineS-AdenosylmethionineSubstratePhosphateS-AdenosylhomocysteineXP_001497466.2COMTPhosphateATPO-methylated substrateQ95LQ5_HORSEXP_001501512.1XP_001503384.1N-methylated substrateS-AdenosylmethionineS-AdenosylhomocysteineXP_001500553.1NNMTS-methylated substrateL-MethionineXP_001490376.2TPMT_HORSE


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP704(r30265) with a 77% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006 PubMed Europe PMC Scholia
  2. Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118396view14:07, 27 May 2021EweitzOntology Term : 'protein modification pathway' added !
106094view12:00, 16 August 2019MaintBotHMDB identifier normalization
79387view20:02, 21 March 2015KhanspersModified title
79386view20:01, 21 March 2015Khanspersupdate schema
79385view20:01, 21 March 2015KhanspersReverted to version '00:33, 21 February 2013' by Khanspers
68744view22:55, 6 July 2013MaintBotUpdated to 2013 gpml schema
58877view00:33, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
40917view22:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
31819view12:23, 14 August 2009MaintBotFixed group labels
30779view23:29, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetaboliteHMDB0000538 (HMDB)
COMTGeneProduct
L-MethionineMetaboliteHMDB0000696 (HMDB)
N-methylated substrateMetabolite
NNMTGeneProduct
O-methylated substrateMetabolite
PhosphateMetaboliteHMDB0001429 (HMDB)
Q95LQ5_HORSEGeneProductENSECAG00000010548 (Ensembl)
S-AdenosylhomocysteineMetaboliteHMDB0000939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB0001185 (HMDB)
S-methylated substrateMetabolite
SubstrateMetabolite
TPMT_HORSEGeneProductENSECAG00000013653 (Ensembl)
XP_001490376.2GeneProductENSECAG00000011592 (Ensembl)
XP_001497466.2GeneProductENSECAG00000007391 (Ensembl)
XP_001500553.1GeneProductENSECAG00000014579 (Ensembl)
XP_001501512.1GeneProductENSECAG00000017602 (Ensembl)
XP_001503384.1GeneProductENSECAG00000021219 (Ensembl)

Annotated Interactions

No annotated interactions
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