Phase I biotransformations, non-P450 (Equus caballus)
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1
OH
OH
Hydrolysis
OH
OH
PON3
LIPA
CES1
carboxylic acid esters
carboxylic acid esters
Phosphoric acid esters
CES5A
PON1
thio esters
ESD
amides
PON2
CES2
Phosphoric acid esters
thio esters
amides
Description
This pathway lists several phase 1 biotransformations and their related enzymes.
Comments
HomologyMapper
This pathway was inferred from Homo sapiens pathway
WP136 (r95126)
with a 100.0% conversion rate.
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Ontology Terms
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Bibliography
Klaassen, C.D., Watkins III, J.B.; ''Casarett & Doull's Essentials of Toxicology''; , 2003
History
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Compare
Revision
Action
Time
User
Comment
128193
view
00:35, 29 January 2024
Eweitz
Modified title
125265
view
12:56, 31 January 2023
Larsgw
Add ISBN to publication
107102
view
14:18, 17 September 2019
MaintBot
ChEBI identifier normalization
95740
view
13:30, 19 January 2018
Mkutmon
updated homology conversion
88306
view
15:28, 1 August 2016
Fehrhart
Ontology Term : 'cytochrome P450-independent phase I biotransformation pathway' added !
73514
view
23:19, 29 January 2014
Khanspers
Modified title
68737
view
22:49, 6 July 2013
MaintBot
Updated to 2013 gpml schema
58870
view
00:33, 21 February 2013
MaintBot
Updated Ensembl and UniProt data source
40909
view
22:41, 1 March 2011
MaintBot
Removed redundant pathway information and comments
31822
view
12:24, 14 August 2009
MaintBot
Fixed group labels
30782
view
23:32, 29 July 2009
MaintBot
New pathway
External references
DataNodes
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Name
Type
Database reference
Comment
CES1
GeneProduct
ENSECAG00000015451 (Ensembl)
Homology Mapping from Homo sapiens to Equus caballus: Original ID = En:ENSG00000198848
CES2
GeneProduct
ENSECAG00000012061 (Ensembl)
Homology Mapping from Homo sapiens to Equus caballus: Original ID = En:ENSG00000172831
CES5A
GeneProduct
ENSECAG00000010588 (Ensembl)
Homology Mapping from Homo sapiens to Equus caballus: Original ID = En:ENSG00000159398
ESD
GeneProduct
ENSECAG00000024350 (Ensembl)
Homology Mapping from Homo sapiens to Equus caballus: Original ID = En:ENSG00000139684
LIPA
GeneProduct
ENSECAG00000010840 (Ensembl)
Homology Mapping from Homo sapiens to Equus caballus: Original ID = En:ENSG00000107798
PON1
GeneProduct
ENSECAG00000000344 (Ensembl)
Homology Mapping from Homo sapiens to Equus caballus: Original ID = En:ENSG00000005421
PON2
GeneProduct
ENSECAG00000010414 (Ensembl)
Homology Mapping from Homo sapiens to Equus caballus: Original ID = En:ENSG00000105854
PON3
GeneProduct
ENSECAG00000009974 (Ensembl)
Homology Mapping from Homo sapiens to Equus caballus: Original ID = En:ENSG00000105852
Phosphoric acid esters
Metabolite
CHEBI:37734 (ChEBI)
amides
Metabolite
CHEBI:32988 (ChEBI)
carboxylic acid esters
Metabolite
CHEBI:33308 (ChEBI)
thio esters
Metabolite
CHEBI:51277 (ChEBI)
Annotated Interactions
No annotated interactions
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View approved pathways at the new wikipathways.org.Quality Tags
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External references
DataNodes
Annotated Interactions
No annotated interactions