Aflatoxin B1 metabolism (Equus caballus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none nonenzymaticnonenzymatic(pH-dependent)DNA adductsAflatoxin B1 C8-monoalcoholAflatoxin-endo-B1-8,9-epoxideAflatoxin B1 exo-8,9-epoxide-GSHXP_001489035.1XP_001493936.1Aflatoxin B1-6,8-dialcoholAflatoxin B1 8,9-dihydrodiolAflatoxin B1 dialdehydeXP_001493936.1aflatoxin B1Aflatoxin B1 exo-8,9-epoxideAflatoxin M1Aflatoxin B1 C8-monoaldehydeAflatoxin M1 epoxideCYP2A13Aflatoxin B1 C6-monoalcoholAflatoxin Q1CYP3A4Aflatoxin B1 C6-monoaldehydeAKR7A2XP_001917301.1XP_001493936.1CYP2A13CYP3A4XP_001489453.1GSTM1Name: Aflatoxin B1 metabolismLast Modified: 2/20/2013Organism: Equus caballus


Description

Aflatoxins are naturally occurring [mycotoxins](https://en.wikipedia.org/wiki/Mycotoxin) that are produced by many species of [Aspergillus](https://en.wikipedia.org/wiki/Aspergillus), a [fungus](https://en.wikipedia.org/wiki/Fungus), most notably [Aspergillus flavus](https://en.wikipedia.org/wiki/Aspergillus_flavus) and [Aspergillus parasiticus](https://en.wikipedia.org/wiki/Aspergillus_parasiticus). After entering the body, aflatoxins are metabolized by the liver to a reactive intermediate, aflatoxin M1, an [epoxide](https://en.wikipedia.org/wiki/Epoxide). Aflatoxin B1 is considered the most toxic and is produced by both Aspergillus flavus and Aspergillus parasiticus. Source: [Wikipedia](https://en.wikipedia.org/wiki/Aflatoxin)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP699(r30253) with a 50% conversion rate.

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes
Image:Unconnected.pngFix interactions
Homology Converted

Ontology Terms

Pathway Ontology : DNA damage response pathway
 

Bibliography

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  1. Zhu LR, Thomas PE, Lu G, Reuhl KR, Yang GY, Wang LD, Wang SL, Yang CS, He XY, Hong JY; ''CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody.''; Drug Metab Dispos, 2006 PubMed Europe PMC Scholia
  2. Tiemersma EW, Omer RE, Bunschoten A, van't Veer P, Kok FJ, Idris MO, Kadaru AM, Fedail SS, Kampman E; ''Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma.''; Cancer Epidemiol Biomarkers Prev, 2001 PubMed Europe PMC Scholia
  3. Stewart RK, Smith GB, Donnelly PJ, Reid KR, Petsikas D, Conlan AA, Massey TE; ''Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B(1) in human lung: differential cellular distribution and lack of significance of the GSTM1 genetic polymorphism.''; Carcinogenesis, 1999 PubMed Europe PMC Scholia
  4. Barski OA, Tipparaju SM, Bhatnagar A; ''The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.''; Drug Metab Rev, 2008 PubMed Europe PMC Scholia
  5. Jin Y, Penning TM; ''Aldo-keto reductases and bioactivation/detoxication.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
  6. Guengerich FP; ''Cytochrome P450s and other enzymes in drug metabolism and toxicity.''; AAPS J, 2006 PubMed Europe PMC Scholia
  7. Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM; ''Reaction of aflatoxin B(1) oxidation products with lysine.''; Chem Res Toxicol, 2002 PubMed Europe PMC Scholia
  8. Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM; ''Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.''; Chem Res Toxicol, 2001 PubMed Europe PMC Scholia
  9. He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY; ''Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract.''; Int J Cancer, 2006 PubMed Europe PMC Scholia
  10. Kensler TW, Qian GS, Chen JG, Groopman JD; ''Translational strategies for cancer prevention in liver.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
136898
Approved
view19:21, 26 February 2025KhanspersModified description
136892view19:18, 26 February 2025KhanspersModified description
106096view12:00, 16 August 2019MaintBotHMDB identifier normalization
68746view22:56, 6 July 2013MaintBotUpdated to 2013 gpml schema
67029view09:56, 26 June 2013Christine ChichesterOntology Term : 'aflatoxin metabolic pathway' added !
58879view00:33, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
57154view13:15, 23 January 2013EgonwUsed "PubChem-compound"
40919view22:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
35016view08:26, 11 February 2010ThomasModified description
32280view13:08, 15 August 2009MaintBotFixed text labels
31825view12:25, 14 August 2009MaintBotFixed group labels
31308view20:13, 13 August 2009MaintBotFixed text labels
30786view23:34, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKR7A2GeneProduct
Aflatoxin B1 8,9-dihydrodiolMetabolite3035008 (PubChem-compound)
Aflatoxin B1 C6-monoalcoholMetabolite
Aflatoxin B1 C6-monoaldehydeMetabolite
Aflatoxin B1 C8-monoalcoholMetabolite
Aflatoxin B1 C8-monoaldehydeMetabolite
Aflatoxin B1 dialdehydeMetabolite
Aflatoxin B1 exo-8,9-epoxide-GSHMetabolite5460816 (PubChem-compound)
Aflatoxin B1 exo-8,9-epoxideMetabolite104756 (PubChem-compound)
Aflatoxin B1-6,8-dialcoholMetabolite
Aflatoxin M1 epoxideMetabolite
Aflatoxin M1Metabolite15558498 (PubChem-compound)
Aflatoxin Q1Metabolite104757 (PubChem-compound)
Aflatoxin-endo-B1-8,9-epoxideMetabolite
CYP2A13GeneProduct
CYP3A4GeneProduct
GSTM1GeneProduct
XP_001489035.1GeneProductENSECAG00000019677 (Ensembl)
XP_001489453.1GeneProductENSECAG00000002100 (Ensembl)
XP_001493936.1GeneProductENSECAG00000008153 (Ensembl)
XP_001917301.1GeneProductENSECAG00000006082 (Ensembl)
aflatoxin B1MetaboliteHMDB0006552 (HMDB)

Annotated Interactions

No annotated interactions
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