Oxidation by cytochrome P450 (Equus caballus)

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1Cytochrome P450 genesXP_001491520.1SubstrateH2OFe2+CYPactivated O2CYP2A13CYP3A43CYP2A6CYP2A7SubstrateXP_001497331.1XP_001488979.2XP_001496962.1CYB5ACYP2B6XP_001491972.1CYP2C8CYP2D6CYP11B1CYP3A5CYPCYP26C1XP_001498220.1Substrate-OHCYP4A11XP_001499815.2CYP2C19XP_001490382.2CYPCP11A_HORSECYPCYP3A7XP_001498224.1NADP+XP_001499963.2CYPSubstrateXP_001495724.2CYP4B1XP_001503107.2XP_001488867.2XP_001492328.1CYP4F8A8WDL7_HORSESubstrateXP_001914769.1CP19A_HORSECYP3A4XP_001493525.2CP17A_HORSECYP2C18Fe3+CYP2S1Fe3+CYP4F11CYP4Z1Fe2+Fe3+XP_001918061.1CYP2C9NAD+XP_001497331.1XP_001915852.1XP_001500294.2Fe3+XP_001502548.1XP_001497396.2B1PL89_HORSEFe2+CYP2G1PXP_001497331.1SubstrateXP_001501478.2O2NADHCYP4F2XP_001493936.1XP_001488205.2CYP4F12CYP4A22Q2LE11_HORSECYB5AA8WCD7_HORSEXP_001918021.1XP_001491520.1CYP2W1Fe2+NADPHO2CYP11B2CYP46A1CYP4F3CYB5AXP_001500786.2


Description

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP43(r29608) with a 50% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Niesink, R.J.M, Vries, de, J., Hollinger, M.A.; ''Toxicology; Principles and Applications''; , 1996

History

View all...
CompareRevisionActionTimeUserComment
118190view10:51, 25 May 2021EweitzModified title
107103view14:18, 17 September 2019MaintBotChEBI identifier normalization
88272view14:35, 1 August 2016FehrhartOntology Term : 'hepatocyte' added !
88271view14:35, 1 August 2016FehrhartOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
88270view14:34, 1 August 2016FehrhartOntology Term : 'xenobiotics biodegradation pathway' added !
80418view10:13, 20 June 2015EgonwWater is not a gene product.
79836view07:41, 18 April 2015EgonwFixed metabolite identifiers.
79407view20:38, 21 March 2015Khanspersupdate schema
79406view20:37, 21 March 2015KhanspersModified title
79405view20:36, 21 March 2015KhanspersReverted to version '00:33, 21 February 2013' by Khanspers
68742view22:53, 6 July 2013MaintBotUpdated to 2013 gpml schema
58875view00:33, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
40915view22:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
31826view12:25, 14 August 2009MaintBotFixed group labels
30788view23:37, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A8WCD7_HORSEGeneProductENSECAG00000013817 (Ensembl)
A8WDL7_HORSEGeneProductENSECAG00000019088 (Ensembl)
B1PL89_HORSEGeneProductENSECAG00000008755 (Ensembl)
CP11A_HORSEGeneProductENSECAG00000017494 (Ensembl)
CP17A_HORSEGeneProductENSECAG00000010022 (Ensembl)
CP19A_HORSEGeneProductENSECAG00000020474 (Ensembl)
CYB5AGeneProduct
CYPGeneProduct
CYP11B1GeneProduct
CYP11B2GeneProduct
CYP26C1GeneProductENSECAG00000023734 (Ensembl)
CYP2A13GeneProduct
CYP2A6GeneProduct
CYP2A7GeneProduct
CYP2B6GeneProduct
CYP2C18GeneProduct
CYP2C19GeneProduct
CYP2C8GeneProduct
CYP2C9GeneProduct
CYP2D6GeneProduct
CYP2G1PGeneProduct
CYP2S1GeneProductENSECAG00000009026 (Ensembl)
CYP2W1GeneProductENSECAG00000022978 (Ensembl)
CYP3A4GeneProduct
CYP3A43GeneProduct
CYP3A5GeneProduct
CYP3A7GeneProduct
CYP46A1GeneProductENSECAG00000007407 (Ensembl)
CYP4A11GeneProduct
CYP4A22GeneProduct
CYP4B1GeneProduct
CYP4F11GeneProduct
CYP4F12GeneProduct
CYP4F2GeneProduct
CYP4F3GeneProduct
CYP4F8GeneProduct
CYP4Z1GeneProduct
Fe2+MetaboliteCHEBI:29033 (ChEBI)
Fe3+MetaboliteCHEBI:29034 (ChEBI)
H2OMetabolite962 (PubChem-compound)
NAD+MetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
O2Metabolite977 (PubChem-compound)
Q2LE11_HORSEGeneProductENSECAG00000025143 (Ensembl)
SubstrateGeneProduct
Substrate-OHGeneProduct
XP_001488205.2GeneProductENSECAG00000017379 (Ensembl)
XP_001488867.2GeneProductENSECAG00000022724 (Ensembl)
XP_001488979.2GeneProductENSECAG00000016322 (Ensembl)
XP_001490382.2GeneProductENSECAG00000016889 (Ensembl)
XP_001491520.1GeneProductENSECAG00000006455 (Ensembl)
XP_001491972.1GeneProductENSECAG00000016208 (Ensembl)
XP_001492328.1GeneProductENSECAG00000019737 (Ensembl)
XP_001493525.2GeneProductENSECAG00000020100 (Ensembl)
XP_001493936.1GeneProductENSECAG00000008153 (Ensembl)
XP_001495724.2GeneProductENSECAG00000009763 (Ensembl)
XP_001496962.1GeneProductENSECAG00000012946 (Ensembl)
XP_001497331.1GeneProductENSECAG00000000265 (Ensembl)
XP_001497396.2GeneProductENSECAG00000023905 (Ensembl)
XP_001498220.1GeneProductENSECAG00000007161 (Ensembl)
XP_001498224.1GeneProductENSECAG00000019834 (Ensembl)
XP_001499815.2GeneProductENSECAG00000019442 (Ensembl)
XP_001499963.2GeneProductENSECAG00000019841 (Ensembl)
XP_001500294.2GeneProductENSECAG00000016096 (Ensembl)
XP_001500786.2GeneProductENSECAG00000008452 (Ensembl)
XP_001501478.2GeneProductENSECAG00000003415 (Ensembl)
XP_001502548.1GeneProductENSECAG00000022244 (Ensembl)
XP_001503107.2GeneProductENSECAG00000021232 (Ensembl)
XP_001914769.1GeneProductENSECAG00000012358 (Ensembl)
XP_001915852.1GeneProductENSECAG00000007540 (Ensembl)
XP_001918021.1GeneProductENSECAG00000010884 (Ensembl)
XP_001918061.1GeneProductENSECAG00000007597 (Ensembl)
activated O2Metabolite

Annotated Interactions

No annotated interactions
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