From WikiPathways
1, 2 Cdt1 Mcm5 Orc complex Origin Mcm10 Orc3 Mcm3 Mcm7 Orc complex Mcm5 Cdc6 Ubiquitinated Orc1 Ubiquitin Orc2 Mcm2 Orc1 RFC36 Cdt1 Degraded by proteasome in cytosol Pre-replicative complex RFC38 Cdc6 RNA primer-DNA primer: origin duplex:PCNA DNA polymerase alpha: primase: origin complex Mcm 4,6,7 trimer forms and associates with the replication fork Cdt1 Mcm2 Phosphorylated Cdc6 Cdc6 Orc complex Cdc6 Pre-replicative complex DNA Polymerase A RFC37 Mcm4 Mcm7 RNA primer-DNA primer Cdt1 RFC Heteropentamer: RNA primer-DNA primer PCNA homotrimer Orc5 Phosphorylation of Mcm 2-7 complex RNA primer-DNA primer RFC140 1. Assembly of the pre-replicative complex p58 Orc2 5. Leading/lagging strand synthesis p70 RFC Heteropentamer: RNA primer-DNA primer Mcm10 Ubiquitin Mcm4 Mcm6 Orc2 Phosphorylated Orc1 Orc3 Orc3 Degraded by proteasome in cytosol Orc5 Cdt1 Ubiquitinated Cdc6 RNA Primer 3. DNA replication initiation p180 Mcm6 Orc5 Processive complex p49 Geminin Orc4 2. Activation of the pre-replicative complex Orc complex Primase Orc2 4. Switching of origins to post-replicative state RFC40 Orc complex DNA polymerase alpha: primase: origin complex Mcm3 Orc3 Orc4 AgaP_AGAP007927 ATP GMNN AgaP_AGAP001290 GTP AgaP_AGAP004615 ASK ADP dGTP AgaP_AGAP007477 AgaP_AGAP005176 AgaP_AGAP001929 AgaP_AGAP006065 AgaP_AGAP010220 CTP AgaP_AGAP008910 AgaP_AGAP000474 dUTP ATP dCTP AgaP_AGAP010219 AgaP_AGAP004408 AgaP_AGAP010406 AgaP_AGAP005144 AgaP_AGAP004579 AgaP_AGAP004614 AgaP_AGAP009047 AgaP_AGAP001971 AgaP_AGAP005800 AgaP_AGAP011246 AgaP_AGAP001421 AgaP_AGAP007063 AgaP_AGAP004956 RPA3 UTP POLD3 AgaP_AGAP004392 POLD1 AgaP_AGAP004957 AgaP_AGAP008332 dATP ATP AgaP_AGAP008723 ADP AgaP_AGAP000978 RPA4 CDC7 AgaP_AGAP011961 AgaP_AGAP004275 AgaP_AGAP001135 AgaP_AGAP005321 POLD4 AgaP_AGAP006387 ATP AgaP_AGAP003093
Description
DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.
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