Folic acid network (Mus musculus)

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2591246, 19231620115152413, 1472818, 1822BBSynthesis of cholineTBCNMain functionsTransformationBFormation of methionineBBBTTBBGeneric enzymeTransportINTRACELULARBTTNucleotide biosynthesisInfluence on expressionBBBBBInterconversionBUnspecified effectTBindingBBReactionIEBBTPLASMATFormation of HemeBBMETABOLITEConversionNegative effectBBTPositive effectBCompetitionBUnspecified interactionBBd4 desaturaseEthanolamineThromboxane B2Leukotriene D4CysteineBEPA (n-3)GlycineCholinePGE3NADPHPGE2C22:5 (n-6)PGFSNicotinamideNADPALA (n-3)Coppera Tocopherol15-HETEROSLipoxin A4DHA (n-3)Uric acid1-methylnicotinamideLeukotrieneE4Leukotriene A4NADPS-Adenosylhomocysteine EthanolamineCysteineCopperLeukotrieneE4SelkCobalaminThromboxane A2Leukotriene B4ManganeseAA (n-6)Fads2Pyridoxal-5'-phosphateSerinePGF2aPGD2MtrThioredoxinMethioninePnpoHemeVitamin B12Txnrd1L-Glutamic acidGlutathione disulfideLeukotriene F4SODGpx6IronIronAA (n-6)Leukotriene C4B1-MethylnicotinamideGsrTGlutathionePGI2NADPHXdhSeleniumGpx2PGG2PtgdsMethylmalonic acidCNH2OZincFMN1L-Glutamic acidS-Adenosylhomocysteine O2Vitamin B12TTLeukotriene C4Gpx1PtgesF2-IsoprostaneMthfrLA (n-6)Ascorbic acidLipoic acidLA (n-6)Leukotriene B4CalciumAlox55-HPETE2-Ketobutyric acidCobalaminSepx12-Ketobutyric acidGpx3iPF2-alphaAdipic acid PGI25,10-METHYL-THFPyridoxal-5'-phosphateTranscobalaminXanthineZincS-Adenosylmethionine KmoL-MethionineHypoxanthineMethylmalonic acid Ascorbic acidFOLIC ACIDTxnrd2a-tocopherolPGH3Leukotriene D4GlutathioneFADTHASDHA (n-3)PGD2NiacinTRXR 3Gpx4d5 desaturasePGG3CalciumCystathionePtgisRiboflavinHomocysteineCOX2H2O2Lipoxin A4Betaine5,10-METHYL-THFEPA (n-3)ALA (n-3)15-HETESepw1SeleniumHomocysteineHypoxanthineCOX1Adipic acidPGF2aEndoperoxidasePGE2S-AdenosylmethionineFOLIC ACIDUric acidGlycineCbsMethionine sulfoxideTromboxane A2SerinePGH2CatC22:5 (n-6)TryptophanLipoxin B4CarnitineIE2, 10262732117


Description

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP176(r30153) with a 58% conversion rate.

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Bibliography

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  1. Vladimir Kery, Loelle Poneleit, Jeffrey D. Meyer, Mark C. Manning, Jan P. Kraus; ''Binding of Pyridoxal 5'-Phosphate to the Heme Protein Human Cystathionine β-Synthase''; Biochemistry 38(9), 1999 DOI Scholia
  2. Proctor PH.; ''Free radicals, uric acid, and human disease.''; Free Radic Biol Med., 1996 PubMed Europe PMC Scholia
  3. Morrow JD, Roberts LJ 2nd.; ''The isoprostanes. Current knowledge and directions for future research.''; Biochem Pharmacol., 1996 PubMed Europe PMC Scholia
  4. Selhub J.; ''Homocysteine metabolism.''; Annu Rev Nutr, 1999 PubMed Europe PMC Scholia
  5. George J, Struthers AD.; ''The role of urate and xanthine oxidase inhibitors in cardiovascular disease.''; Cardiovasc Ther., 2008 PubMed Europe PMC Scholia
  6. Fernandes-Costa F: Metz J.; ''Vitamin B12 binders (transcobalamins) in serum.''; Crit Rev Clin Lab Sci. , 1982 PubMed Europe PMC Scholia
  7. Longhi RC, Fleisher LD, Tallan HH, Gaull GE.; ''Cystathionine beta-synthase deficiency: a qualitative abnormality of the deficient enzyme modified by vitamin B6 therapy.''; Pediatr Res. , 1977 PubMed Europe PMC Scholia
  8. Selhub J.; ''Homocysteine metabolism.''; Annu Rev Nutr. , 1999 PubMed Europe PMC Scholia
  9. https://analysis.ingenuity.com/pa/; ''Prostaglandin and Leukotriene Metabolism''; Ingenuity software
  10. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC Scholia
  11. Basu S.; ''Isoprostanes: novel bioactive products of lipid peroxidation.''; Free Radic Res., 2004 PubMed Europe PMC Scholia
  12. Fowler B.; ''Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. ''; Semin Vasc Med, 2005 PubMed Europe PMC Scholia
  13. Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML.; ''Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.''; Nat Struct Biol. , 2002 PubMed Europe PMC Scholia
  14. Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, Gravel RA, Rozen R; ''A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. ''; Molecular genetics and metabolism, 1999 PubMed Europe PMC Scholia
  15. Singh U, Devaraj S, Jialal I.; ''Vitamin E, oxidative stress, and inflammation.''; Annu Rev Nutr., 2005 PubMed Europe PMC Scholia
  16. Petersen Shay K, Moreau RF, Smith EJ, Hagen TM.; ''Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.''; IUBMB Life., 2008 PubMed Europe PMC Scholia
  17. https://analysis.ingenuity.com/; ''Arachidonic Acid Metabolism''; Ingenuity sofware
  18. Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M, Eydoux P, Rosenblatt DS, Rozen R, Gravel RA.; ''Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. ''; Hum Mol Genet. , 1996 PubMed Europe PMC Scholia
  19. Hall CA; ''Transcobalamins I and II as natural transport proteins of vitamin B12. ''; The Journal of clinical investigation , 1975 PubMed Europe PMC Scholia
  20. Kryukov GV, Kumar RA, Koc A, Sun Z, Gladyshev VN.; ''Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.''; Proc Natl Acad Sci U S A. , 2002 PubMed Europe PMC Scholia
  21. WikiPathways; ''Selenoproteins''; http://www.wikipathways.org/index.php/Pathway:Homo_sapiens:Selenoproteins
  22. http://lpi.oregonstate.edu/infocenter/vitamins/fa/; ''Folic acid''; Linus Pauling Institute
  23. Lu C, Qiu F, Zhou H, Peng Yp, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X.; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.''; FEBS Lett., 2006 PubMed Europe PMC Scholia
  24. https://analysis.ingenuity.com/; ''Prostaglandin and Leukotriene Metabolism''; Ingenuity software
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  26. ''Food and Nutrition Board, Institute of Medicine. Vitamin B6. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Vitamin B12, Pantothenic Acid, Biotin, and Choline.''; Washington D.C.: National Academies Press, 1998
  27. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone''; Prostaglandins., 1982 PubMed Europe PMC Scholia
  28. Ben van Ommen, Susan Fairweather-Tait, Andreas Freidig, Alwine Kardinaal, Augustin Scalbert, Suzan Wopereis; ''A network biology model of micronutrient related health''; Br J Nutr, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
125270view14:50, 31 January 2023LarsgwFix references
125269view14:49, 31 January 2023LarsgwFix references
124807view21:39, 11 December 2022AlexanderPicofixed ontology tag
124806view21:39, 11 December 2022AlexanderPicofixed citations
124777view06:26, 11 December 2022AlexanderPicofixed citations
120917view06:29, 31 January 2022EgonwReplaced an old HMDB identifier with the current one
118150view10:40, 25 May 2021EweitzModified title
114089view07:24, 22 December 2020EgonwRemoved duplicate reference info
114033view15:51, 17 December 2020LaurentConnected lines
106851view13:33, 17 September 2019MaintBotHMDB identifier normalization
101980view20:31, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
101976view20:00, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
85058view10:53, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
82696view18:11, 22 October 2015EgonwFixed a typo.
74467view16:12, 24 April 2014EgonwFixed a PubMed ID.
69126view18:14, 8 July 2013MaintBotUpdated to 2013 gpml schema
69056view18:04, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
68384view09:42, 4 July 2013EgonwMade the link to Wikipedia machine readable.
68383view09:41, 4 July 2013EgonwFixed the DataNode type of two nodes with gene identifiers.
67254view10:27, 26 June 2013Christine ChichesterOntology Term : 'pathway of folate cycle/metabolism' added !
60224view20:01, 14 March 2013EgonwReplaced PubChem-substance with PubChem-compound.
59041view20:43, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48256view21:44, 17 May 2012KhanspersUpdating PubChem xrefs
48230view05:32, 17 May 2012MaintBotAutomatic update of PubChem xrefs
43782view20:38, 27 July 2011Samuel SklarSpecify description
43781view19:18, 27 July 2011Samuel SklarPeriodical save, work in progress
42731view22:19, 24 April 2011MaintBotfixed blank db refs
42730view22:17, 24 April 2011MaintBotfixed odd db refs
41311view00:24, 2 March 2011MaintBotRemoved redundant pathway information and comments
34393view22:53, 9 December 2009MaintBotAutomatic update of empty xrefs
33189view18:05, 5 November 2009KhanspersModified categories
32300view13:16, 15 August 2009MaintBotFixed text labels
31873view12:39, 14 August 2009MaintBotFixed group labels
31329view20:21, 13 August 2009MaintBotFixed text labels
30907view00:26, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-MethylnicotinamideMetaboliteHMDB0000699 (HMDB)
1-methylnicotinamideMetaboliteHMDB0000699 (HMDB)
15-HETEMetaboliteHMDB0011134 (HMDB)
2-Ketobutyric acidMetaboliteHMDB0000005 (HMDB)
5,10-METHYL-THFMetaboliteHMDB0001396 (HMDB)
5-HPETEMetaboliteHMDB0001193 (HMDB)
AA (n-6)MetaboliteHMDB0001043 (HMDB)
ALA (n-3)MetaboliteHMDB0001388 (HMDB)
Adipic acid MetaboliteHMDB0000448 (HMDB)
Adipic acidMetaboliteHMDB0000448 (HMDB)
Alox5Protein11689 (Entrez Gene)
Ascorbic acidMetaboliteHMDB0000044 (HMDB)
BGeneProduct
BetaineMetaboliteHMDB0000043 (HMDB)
C22:5 (n-6)MetaboliteHMDB0001976 (HMDB)
CN
COX1Protein3337205 (Entrez Gene)
COX2Protein3337209 (Entrez Gene)
CalciumMetaboliteHMDB0000464 (HMDB)
CarnitineMetaboliteHMDB0000062 (HMDB)
CatProtein12359 (Entrez Gene)
CbsProtein12411 (Entrez Gene)
CholineMetaboliteHMDB0000097 (HMDB)
CobalaminMetaboliteHMDB0002174 (HMDB)
CopperMetaboliteHMDB0000657 (HMDB)
CystathioneMetaboliteHMDB0000099 (HMDB)
CysteineMetaboliteHMDB0000574 (HMDB)
DHA (n-3)MetaboliteHMDB0002183 (HMDB)
EPA (n-3)MetaboliteHMDB0001999 (HMDB)
EndoperoxidaseProtein
EthanolamineMetaboliteHMDB0000149 (HMDB)
F2-IsoprostaneMetaboliteHMDB0004659 (HMDB)
FADMetabolite703 (PubChem-compound)
FMN1GeneProduct342184 (Entrez Gene)
FOLIC ACIDMetaboliteHMDB0000121 (HMDB)
Fads2Protein56473 (Entrez Gene)
Glutathione disulfideMetabolite65359 (PubChem-compound) Type your comment here
GlutathioneMetaboliteHMDB0000125 (HMDB)
GlycineMetaboliteHMDB0000123 (HMDB)
Gpx1Protein14775 (Entrez Gene)
Gpx2Protein14776 (Entrez Gene)
Gpx3Protein14778 (Entrez Gene)
Gpx4Protein625249 (Entrez Gene)
Gpx6Protein75512 (Entrez Gene)
GsrProteinENSMUSG00000031584 (Ensembl) Type your comment here
H2O2MetaboliteHMDB0003125 (HMDB)
H2OMetaboliteHMDB0002111 (HMDB)
HemeMetaboliteHMDB0003178 (HMDB)
HomocysteineMetabolite
HomocysteineMetaboliteHMDB0000742 (HMDB)
HypoxanthineMetaboliteHMDB0000157 (HMDB)
IE
IronMetaboliteHMDB0000692 (HMDB)
KmoProtein98256 (Entrez Gene)
L-Glutamic acidMetaboliteHMDB0000148 (HMDB)
L-MethionineMetaboliteHMDB0000696 (HMDB)
LA (n-6)MetaboliteHMDB0000673 (HMDB)
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene F4Metabolite
LeukotrieneE4MetaboliteHMDB0002200 (HMDB)
Lipoic acidMetaboliteHMDB0001451 (HMDB)
Lipoxin A4MetaboliteHMDB0004385 (HMDB)
Lipoxin B4MetaboliteHMDB0005082 (HMDB)
ManganeseMetaboliteHMDB0001333 (HMDB)
Methionine sulfoxideMetaboliteHMDB0002005 (HMDB)
MethionineMetaboliteHMDB0000696 (HMDB)
Methylmalonic acid MetaboliteHMDB0000202 (HMDB)
Methylmalonic acidMetaboliteHMDB0000202 (HMDB)
MthfrProtein17769 (Entrez Gene)
MtrProtein238505 (Entrez Gene)
NADPHMetaboliteHMDB0000221 (HMDB)
NADPMetaboliteHMDB0000217 (HMDB)
NiacinMetaboliteHMDB0001406 (HMDB)
NicotinamideMetabolite936 (PubChem-compound)
O2MetaboliteHMDB0001377 (HMDB)
PGD2MetaboliteHMDB0001403 (HMDB)
PGE2Metabolite
PGE3MetaboliteHMDB0002664 (HMDB)
PGF2aMetaboliteHMDB0001139 (HMDB)
PGFSProtein
PGG2MetaboliteHMDB0003235 (HMDB)
PGG3Metabolite
PGH2MetaboliteHMDB0001381 (HMDB)
PGH3Metabolite
PGI2Metabolite
PGI2MetaboliteHMDB0001335 (HMDB)
PnpoProtein103711 (Entrez Gene)
PtgdsProtein19215 (Entrez Gene)
PtgesProtein64292 (Entrez Gene)
PtgisProtein19223 (Entrez Gene)
Pyridoxal-5'-phosphateMetaboliteHMDB0001491 (HMDB)
ROSMetaboliteCHEBI:26523 (ChEBI) http://en.wikipedia.org/wiki/Reactive_oxygen_species
RiboflavinMetaboliteHMDB0000244 (HMDB) Type your comment here
S-Adenosylhomocysteine MetaboliteHMDB0000939 (HMDB)
S-Adenosylmethionine MetaboliteHMDB0001185 (HMDB)
S-AdenosylmethionineMetaboliteHMDB0001185 (HMDB)
SODProtein
SeleniumMetaboliteHMDB0001349 (HMDB)
SelkProtein80795 (Entrez Gene)
Sepw1Protein20364 (Entrez Gene)
Sepx1Protein27361 (Entrez Gene)
SerineMetaboliteHMDB0000187 (HMDB)
T
THASProtein
TRXR 3Protein
TT
ThioredoxinProtein7295 (Entrez Gene)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)
TranscobalaminProtein
Tromboxane A2MetaboliteHMDB0001452 (HMDB)
TryptophanMetaboliteHMDB0000929 (HMDB)
Txnrd1Protein50493 (Entrez Gene)
Txnrd2Protein26462 (Entrez Gene)
Uric acidMetaboliteHMDB0000289 (HMDB)
Vitamin B12MetaboliteHMDB0000607 (HMDB)
XanthineMetaboliteHMDB0000292 (HMDB)
XdhProtein22436 (Entrez Gene)
ZincMetaboliteHMDB0015532 (HMDB)
a TocopherolMetaboliteHMDB0001893 (HMDB)
a-tocopherolMetaboliteHMDB0001893 (HMDB)
d4 desaturaseProtein
d5 desaturaseProtein
iPF2-alphaMetaboliteHMDB0004659 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1273"
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