Senescence and autophagy (Rattus norvegicus)

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11PlauCol3a1Tnfsf15Cdkn2aHrasIng2Cdc25bMdm2Slc39a2MtorCol1a1Tp53BrafMap2k1Tgfb1Ing1Ifnb1Sqstm1Cdk6Raf1Igf1rCdk4Rb1SrcSmad4Ccl3Igfbp7Becn1Hmga1InhbaCdkn2aSlc39a3Il6Rsl1d1Cdkn1aTHBS1Cdkn2aAtg12Atg10IL8IL3Map2k3Akt1Smad3Sh3glb1GsnIl6stISREAtg7ATG5Mapk14PlatAtg14Mll1Irf5Ins1Slc39a1Mmp14Cdk2Igf1Gabarapl1Irf1Cdkn1aBcl2Becn1Il6raSerpinb2Cdkn1aIl24RnaselCxcl2Gadd45aUvragPI3K?Atg4bFn1Ambra1Col10a1JunSparcGabarapCdkn2aCebpbSerpine1Map1lc3bPcnaIfngLamp2?IFI16E2f1Gsk3bGASCdkn1bMmp3Map2k3Lamp1Gabarapl2PtenIl1bCxcl14Ulk1Vtnbcl-xlBmi1Cxcl3Cdk2Igfbp3Slc39a4Bmp2Map1lc3aCdkn1aIrf7Cdkn1aATG16Atg7Igfbp5Il1aCd44Atg3Mapk1Creg1


Description

Senescense and Autophagy Pathways in Cancer

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP615(r29697) with a 92% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS; ''Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.''; Cell, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117009view11:21, 16 May 2021EweitzModified title
86844view14:52, 13 July 2016MkutmonOntology Term : 'cellular senescence pathway' added !
86843view14:52, 13 July 2016MkutmonOntology Term : 'PW:0000277' removed !
72036view13:30, 24 October 2013SusanAnnotation and connected lines
71771view20:30, 17 October 2013MaintBotAutomated update of data sources
69337view18:51, 8 July 2013MaintBotUpdated to 2013 gpml schema
67636view11:36, 26 June 2013DdiglesOntology Term : 'senescence pathway' added !
48390view22:37, 23 May 2012Khanspersupdated xrefs
47752view04:20, 6 April 2012Khanspersupdated xrefs
47751view04:11, 6 April 2012KhanspersPeriodical save, work in progress
41649view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
34050view19:02, 9 December 2009MaintBotAutomatic update of empty xrefs
32757view23:38, 3 September 2009MaintBotModified categories
31901view12:47, 14 August 2009MaintBotFixed group labels
30999view01:00, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?GeneProduct
ATG16GeneProduct
ATG5GeneProduct365601 (Entrez Gene)
Akt1GeneProductENSRNOG00000028629 (Ensembl)
Ambra1GeneProduct59319 (Entrez Gene)
Atg10GeneProduct688555 (Entrez Gene)
Atg12GeneProduct361321 (Entrez Gene)
Atg14GeneProductENSRNOG00000011873 (Ensembl)
Atg3GeneProduct171415 (Entrez Gene)
Atg4bGeneProductENSRNOG00000018403 (Ensembl)
Atg7GeneProduct312647 (Entrez Gene)
Bcl2GeneProduct24224 (Entrez Gene)
Becn1GeneProduct114558 (Entrez Gene)
Becn1GeneProductENSRNOG00000020513 (Ensembl)
Bmi1GeneProduct307151 (Entrez Gene) ARF
Bmp2GeneProduct29373 (Entrez Gene) tPA
BrafGeneProduct114486 (Entrez Gene)
Ccl3GeneProduct25542 (Entrez Gene)
Cd44GeneProduct25406 (Entrez Gene)
Cdc25bGeneProduct171103 (Entrez Gene)
Cdk2GeneProduct362817 (Entrez Gene) ARF
Cdk4GeneProduct94201 (Entrez Gene) ARF
Cdk6GeneProduct114483 (Entrez Gene) ARF
Cdkn1aGeneProduct114851 (Entrez Gene) P21/CIP1/WAF1
Cdkn1bGeneProduct83571 (Entrez Gene) P27/KIP
Cdkn2aGeneProduct25163 (Entrez Gene) ARF
CebpbGeneProduct24253 (Entrez Gene)
Col10a1GeneProduct25681 (Entrez Gene) MKK3
Col1a1GeneProduct29393 (Entrez Gene)
Col3a1GeneProduct84032 (Entrez Gene)
Creg1GeneProduct289185 (Entrez Gene)
Cxcl14GeneProduct306748 (Entrez Gene) BRAK
Cxcl2GeneProductENSRNOG00000002792 (Ensembl)
Cxcl3GeneProduct171551 (Entrez Gene) GROa
E2f1GeneProduct399489 (Entrez Gene)
Fn1GeneProduct25661 (Entrez Gene)
GASGeneProductDNA regulatory element
GabarapGeneProduct58974 (Entrez Gene)
Gabarapl1GeneProduct689161 (Entrez Gene)
Gabarapl2GeneProduct64670 (Entrez Gene)
Gadd45aGeneProductENSRNOG00000005615 (Ensembl)
Gsk3bGeneProduct84027 (Entrez Gene)
GsnGeneProduct296654 (Entrez Gene)
Hmga1GeneProduct117062 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene) H-RAS
IFI16GeneProduct
IL3GeneProduct24495 (Entrez Gene)
IL8GeneProduct
ISREGeneProductDNA regulatory element
Ifnb1GeneProduct24481 (Entrez Gene)
IfngGeneProduct25712 (Entrez Gene)
Igf1GeneProduct24482 (Entrez Gene)
Igf1rGeneProduct25718 (Entrez Gene)
Igfbp3GeneProduct24484 (Entrez Gene)
Igfbp5GeneProduct25285 (Entrez Gene)
Igfbp7GeneProduct289560 (Entrez Gene) ARF
Il1aGeneProduct24493 (Entrez Gene)
Il1bGeneProduct24494 (Entrez Gene)
Il24GeneProduct170819 (Entrez Gene)
Il6GeneProduct24498 (Entrez Gene)
Il6raGeneProduct24499 (Entrez Gene)
Il6stGeneProduct25205 (Entrez Gene)
Ing1GeneProduct306626 (Entrez Gene)
Ing2GeneProduct290744 (Entrez Gene)
InhbaGeneProduct29200 (Entrez Gene)
Ins1GeneProductENSRNOG00000012052 (Ensembl) BRAK
Irf1GeneProduct24508 (Entrez Gene)
Irf5GeneProduct296953 (Entrez Gene)
Irf7GeneProduct293624 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene) P21/CIP1/WAF1
Lamp1GeneProduct25328 (Entrez Gene)
Lamp2GeneProduct24944 (Entrez Gene)
Map1lc3aGeneProduct362245 (Entrez Gene)
Map1lc3bGeneProduct64862 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene) MEK
Map2k3GeneProduct303200 (Entrez Gene) MEK6
Mapk1GeneProduct116590 (Entrez Gene) ERK
Mapk14GeneProduct81649 (Entrez Gene) P38a
Mdm2GeneProduct314856 (Entrez Gene)
Mll1GeneProduct315606 (Entrez Gene) ARF
Mmp14GeneProduct81707 (Entrez Gene)
Mmp3GeneProduct171045 (Entrez Gene)
MtorGeneProduct56718 (Entrez Gene) mTOR
PI3K?GeneProduct
PcnaGeneProduct25737 (Entrez Gene)
PlatGeneProduct25692 (Entrez Gene) tPA
PlauGeneProduct25619 (Entrez Gene) uPA
PtenGeneProduct50557 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
Rb1GeneProduct24708 (Entrez Gene)
RnaselGeneProduct359726 (Entrez Gene)
Rsl1d1GeneProduct302898 (Entrez Gene)
Serpinb2GeneProduct60325 (Entrez Gene)
Serpine1GeneProduct24617 (Entrez Gene) PAI1
Sh3glb1GeneProduct292156 (Entrez Gene) BIF1
Slc39a1GeneProduct361986 (Entrez Gene)
Slc39a2GeneProduct305846 (Entrez Gene)
Slc39a3GeneProduct314637 (Entrez Gene)
Slc39a4GeneProduct300051 (Entrez Gene)
Smad3GeneProduct25631 (Entrez Gene)
Smad4GeneProduct50554 (Entrez Gene)
SparcGeneProduct24791 (Entrez Gene)
Sqstm1GeneProduct113894 (Entrez Gene)
SrcGeneProduct83805 (Entrez Gene)
THBS1GeneProduct445442 (Entrez Gene)
Tgfb1GeneProduct59086 (Entrez Gene)
Tnfsf15GeneProduct252878 (Entrez Gene)
Tp53GeneProduct24842 (Entrez Gene)
Ulk1GeneProduct360827 (Entrez Gene) ATG1
UvragGeneProduct308846 (Entrez Gene)
VtnGeneProduct29169 (Entrez Gene)
bcl-xlGeneProduct

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1305"
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