EPO receptor signaling (Danio rerio)

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The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: [Wikipedia](https://en.wikipedia.org/wiki/Erythropoietin_receptor) This pathway is based on ScienceSlides.

HomologyConvert 

This pathway was inferred from Homo sapiens pathway WP581(r22574) with a 77% conversion rate.