TGF-beta receptor signaling pathway (Danio rerio)

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NUNUMitochondriaCYERRecruitmentCYPlasma membraneDesumoylationNUCYDeacetylationEnzyme complexCYMTGlycosylation(Protein-protein interaction)ControlUbiquitinationNUNUReceptorNUDeubiquitinationENNU -> CYNUNUCYNUDephosphorylationNULigandMethylationGolgi apparatusExtracellularNUCYNUCYReaction through unknown mechanisms/moleculesCYCYCYCYPMGOCYCYEndoplasmic reticulumECNUNucleusPalmitoylationCYNUProteins in a complex interactionAcetylationNUNU -> CYNUCytoplasmNUCYCYCYNUCYNUNUEndosomeGlycosylationDemethylationNUNUCYCYInhibitionCYCYCYTranslocationNUNUAutophosphorylationNUCYDActivationCYAccession Number: NetPath 7; cellmap:7Molecule in the pathwayNUPhosphorylationNUCYCYSumoylationMolecular associationProteolytic cleavagezgc:56417LOC558054smad3bprkcb1tgfbr2Gene Symbolwwp1kpnb1hdac1cav1PIAS1cul1actcfarzgc:153726nfyctgfbr2smad3bzgc:55886E2F5fntatp73LOC571621ap2b1UBE2D1strapanapc5LOC558054mapk14aLOC798352camk2d2LOC558054zgc:101872snx6YAP1skiaLOC563719mef2cbRBX1smad7pik3r2LOC561059smurf2rbl1e2f4RBX1tgfbr1bLOC557385cdc23zgc:172209TGFB1LOC100003514tgfb3LOC557385zgc:101872PRKCDsmad7rbl1LOC556403LOC562862LOC558054tgfb2eif3s2zeb2amap3k7wu:fi05d05cul1apias2tfdp2strapjundsdc2smurf2smad2E2F5ppp2r2datf2ltgfbr2tgfbr2FKBP1Alef1hoxd9asmad3bE2F5NFYAMAP2K3hspa8CH211-127H20.1e2f4tgfb2mef2aLOC559111tp53cdc27smad3bsparczgc:153624tgfb2RBX1LOC559111SKP1Ae2f4zfhx1cdc27esr1tgfbr2smad3bLOC798352axin2TGFB1CDKN1ALOC100150936cdc16cdc16camk2atgfbr2tgfb3LOC559111tfdp2E2F5pard3tgfbr2foxo5ctnnb1runx2ae2f4smad3besr1tgfb3BTRCCAMK2GLOC557176e2f4snx6snw1ccnb2map2k6LOC559111ARRB2fzr1FOXO1ABTRCatf3TGFB1axin1cdc23TGFB1cul1azgc:152984rbl1map3k7ip1kpnb1snx1foxg1daxxENGsmad3bsp1prkar2aarb1cdc27rbl1zgc:110180ep300aCRI2smad2ube2d2rb1smad3bcops5tgfbr1bLOC100150936LOC560032ROCK1zgc:92354ccnegipc1kat2brbl1cdc2smad2mapk14aLOC559111LOC793054LOC564395tgfb3acvrl1tgfbr1bncoa1SKP1AJUNBsb:cb458LOC558054smad2tgfbr2tgfbr1bcrebbpbCH211-160M22.1zgc:172209e2f4smad7LOC561059CD44SUMO1tgif1snx2tgfbr2dcp1afoxh1LOC100006682CH211-127H20.1CDC25AMYCdcp1ahnf4aNFYBLOC570542foscdk2TRAP1tfdp2LOC100150936LOC558054E2F5E2F5anapc5rb1wwp1LOC798222CH211-57G18.2ROCK1vdrbsmad3bjuntgfbr2ets1ahgsCH211-160M22.1LOC559111ccnd1SNIP1snx4


Description

No description

Comments

GenMAPP notes 
NetPath 7; cellmap:7 - TGF-beta Receptor Signaling Pathway

The TGF-beta Receptor Signaling pathway was kindly reviewed by Van Le Hong, Wei He and other members of Joan Massague’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP366(r21445) with a 83% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
116913view11:50, 15 May 2021EweitzModified title
87760view09:57, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87758view09:57, 25 July 2016MirellaKalafatiModified title
68624view04:35, 6 July 2013MaintBotUpdated to 2013 gpml schema
40788view22:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
34178view21:20, 9 December 2009MaintBotAutomatic update of empty xrefs
31379view20:40, 13 August 2009MaintBotFixed text labels
31078view01:32, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARRB2GeneProduct
BTRCGeneProduct
CAMK2GGeneProduct
CD44GeneProduct
CDC25AGeneProduct
CDKN1AGeneProduct100151416 (Entrez Gene)
CH211-127H20.1GeneProduct558402 (Entrez Gene)
CH211-160M22.1GeneProduct568795 (Entrez Gene)
CH211-57G18.2GeneProduct100005449 (Entrez Gene)
CRI2GeneProduct
E2F5GeneProduct373090 (Entrez Gene)
ENGGeneProduct
FKBP1AGeneProduct
FOXO1AGeneProduct768121 (Entrez Gene)
Gene SymbolGeneProduct
JUNBGeneProduct407086 (Entrez Gene)
LOC100003514GeneProduct100003514 (Entrez Gene)
LOC100006682GeneProduct100006682 (Entrez Gene)
LOC100150936GeneProduct100150936 (Entrez Gene)
LOC556403GeneProduct556403 (Entrez Gene)
LOC557176GeneProduct557176 (Entrez Gene)
LOC557385GeneProduct557385 (Entrez Gene)
LOC558054GeneProduct558054 (Entrez Gene)
LOC559111GeneProduct559111 (Entrez Gene)
LOC560032GeneProduct560032 (Entrez Gene)
LOC561059GeneProduct561059 (Entrez Gene)
LOC562862GeneProduct562862 (Entrez Gene)
LOC563719GeneProduct563719 (Entrez Gene)
LOC564395GeneProduct564395 (Entrez Gene)
LOC570542GeneProduct570542 (Entrez Gene)
LOC571621GeneProduct571621 (Entrez Gene)
LOC793054GeneProduct793054 (Entrez Gene)
LOC798222GeneProduct798222 (Entrez Gene)
LOC798352GeneProduct798352 (Entrez Gene)
MAP2K3GeneProduct
MYCGeneProduct
NFYAGeneProduct83915 (Entrez Gene)
NFYBGeneProduct503744 (Entrez Gene)
PIAS1GeneProduct
PRKCDGeneProduct334571 (Entrez Gene)
RBX1GeneProduct449846 (Entrez Gene)
ROCK1GeneProduct
SKP1AGeneProduct
SNIP1GeneProduct793873 (Entrez Gene)
SUMO1GeneProduct406438 (Entrez Gene)
TGFB1GeneProduct359834 (Entrez Gene)
TRAP1GeneProduct571959 (Entrez Gene)
UBE2D1GeneProduct324015 (Entrez Gene)
YAP1GeneProduct561411 (Entrez Gene)
acvrl1GeneProduct266753 (Entrez Gene)
anapc5GeneProduct322854 (Entrez Gene)
ap2b1GeneProduct334632 (Entrez Gene)
arGeneProduct100005148 (Entrez Gene)
atf2lGeneProduct100006516 (Entrez Gene)
atf3GeneProduct393939 (Entrez Gene)
axin1GeneProduct57931 (Entrez Gene)
axin2GeneProduct58080 (Entrez Gene)
camk2aGeneProduct550436 (Entrez Gene)
camk2d2GeneProduct436815 (Entrez Gene)
cav1GeneProduct323695 (Entrez Gene)
ccnb2GeneProduct368316 (Entrez Gene)
ccnd1GeneProduct30222 (Entrez Gene)
ccneGeneProduct30188 (Entrez Gene)
cdc16GeneProduct562014 (Entrez Gene)
cdc23GeneProduct393907 (Entrez Gene)
cdc27GeneProduct30450 (Entrez Gene)
cdc2GeneProduct80973 (Entrez Gene)
cdk2GeneProduct406715 (Entrez Gene)
cops5GeneProduct393698 (Entrez Gene)
crebbpbGeneProduct503776 (Entrez Gene)
ctcfGeneProduct415104 (Entrez Gene)
ctnnb1GeneProduct30265 (Entrez Gene)
cul1aGeneProduct323883 (Entrez Gene)
daxxGeneProduct561006 (Entrez Gene)
dcp1aGeneProduct360153 (Entrez Gene)
e2f4GeneProduct406741 (Entrez Gene)
eif3s2GeneProduct406263 (Entrez Gene)
ep300aGeneProduct559273 (Entrez Gene)
esr1GeneProduct259252 (Entrez Gene)
ets1aGeneProduct280651 (Entrez Gene)
fntaGeneProduct555882 (Entrez Gene)
fosGeneProduct394198 (Entrez Gene)
foxg1GeneProduct30274 (Entrez Gene)
foxh1GeneProduct57930 (Entrez Gene)
foxo5GeneProduct30296 (Entrez Gene)
fzr1GeneProduct393223 (Entrez Gene)
gipc1GeneProduct445568 (Entrez Gene)
hdac1GeneProduct192302 (Entrez Gene)
hgsGeneProduct334175 (Entrez Gene)
hnf4aGeneProduct322358 (Entrez Gene)
hoxd9aGeneProduct30350 (Entrez Gene)
hspa8GeneProduct573376 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
jundGeneProduct564873 (Entrez Gene)
kat2bGeneProduct563942 (Entrez Gene)
kpnb1GeneProduct570700 (Entrez Gene)
lef1GeneProduct30701 (Entrez Gene)
map2k6GeneProduct65239 (Entrez Gene)
map3k7GeneProduct553788 (Entrez Gene)
map3k7ip1GeneProduct403084 (Entrez Gene)
mapk14aGeneProduct65237 (Entrez Gene)
mef2aGeneProduct30564 (Entrez Gene)
mef2cbGeneProduct798771 (Entrez Gene)
ncoa1GeneProduct563288 (Entrez Gene)
nfycGeneProduct323445 (Entrez Gene)
pard3GeneProduct403050 (Entrez Gene)
pias2GeneProduct564149 (Entrez Gene)
pik3r2GeneProduct404211 (Entrez Gene)
ppp2r2dGeneProduct327263 (Entrez Gene)
prkar2aaGeneProduct556042 (Entrez Gene)
prkcb1GeneProduct393953 (Entrez Gene)
rb1GeneProduct777733 (Entrez Gene)
rbl1GeneProduct795522 (Entrez Gene)
runx2aGeneProduct405784 (Entrez Gene)
sb:cb458GeneProduct368323 (Entrez Gene)
sdc2GeneProduct282667 (Entrez Gene)
skiaGeneProduct30101 (Entrez Gene)
smad2GeneProduct30639 (Entrez Gene)
smad3bGeneProduct326283 (Entrez Gene)
smad7GeneProduct326282 (Entrez Gene)
smurf2GeneProduct563633 (Entrez Gene)
snw1GeneProduct321852 (Entrez Gene)
snx1GeneProduct337386 (Entrez Gene)
snx2GeneProduct568737 (Entrez Gene)
snx4GeneProduct323203 (Entrez Gene)
snx6GeneProduct567182 (Entrez Gene)
sp1GeneProduct324109 (Entrez Gene)
sparcGeneProduct321357 (Entrez Gene)
strapGeneProduct393274 (Entrez Gene)
tfdp2GeneProduct338204 (Entrez Gene)
tgfb2GeneProduct369194 (Entrez Gene)
tgfb3GeneProduct369195 (Entrez Gene)
tgfbr1bGeneProduct792928 (Entrez Gene)
tgfbr2GeneProduct30739 (Entrez Gene)
tgif1GeneProduct321756 (Entrez Gene)
tp53GeneProduct30590 (Entrez Gene)
tp73GeneProduct368221 (Entrez Gene)
ube2d2GeneProduct335444 (Entrez Gene)
vdrbGeneProduct564511 (Entrez Gene)
wu:fi05d05GeneProduct793303 (Entrez Gene)
wwp1GeneProduct321695 (Entrez Gene)
zeb2aGeneProduct100003889 (Entrez Gene)
zfhx1GeneProduct114425 (Entrez Gene)
zgc:101872GeneProduct494046 (Entrez Gene)
zgc:110180GeneProduct550537 (Entrez Gene)
zgc:152984GeneProduct566811 (Entrez Gene)
zgc:153624GeneProduct767685 (Entrez Gene)
zgc:153726GeneProduct777730 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)
zgc:55886GeneProduct393934 (Entrez Gene)
zgc:56417GeneProduct795019 (Entrez Gene)
zgc:92354GeneProduct492346 (Entrez Gene)

Annotated Interactions

No annotated interactions
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