TNF-alpha NF-kB signaling pathway (Danio rerio)

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ENDCytoplasmDemethylationGolgi apparatusCY ->NUEnzyme complexAccession Number: NetPath 9; cellmap:9DephosphorylationAcetylationEndosomePalmitoylationCY ->NUDesumoylationNUProteolytic cleavageMitochondrionCY ->NUGO(Protein-protein interaction)DeacetylationECRecruitmentDeubiquitinationReceptorActivationSumoylationLigandMolecule in the pathwayNucleusExtracellularMethylationCYInhibitionPlasma membraneAutophosphorylationERMolecular associationGlycosylationMTPMEndoplasmic reticulumCY ->NUUbiquitinationControlCY ->NUReaction through unknown mechanisms/moleculesProteins in a complex interactionPhosphorylationTranslocationkcnq1trpc4aparps11zfand5aPMLTNFcraddtbk1RELcapn3pbppsmb5LOC571171wu:fj98a08tnfrsf1aNFKB1psmd12LOC792354hspb1ripk1lfaf1Gene Symbolmap3k7ip3llrpprcktn1LOC564279ikbkgmap3k3wu:fc75f05SKP1AIQGAP2polr1cLOC563727ikbkaplpfdn2YWHABfkbp5casp8l2cul1atraf4aywhae1casp2LOC565656NFKBIBprkczptpn11zgc:76869UNC5CLLOC795364Genetxlnawdr68ripk2pdcd2ikbkbfblrpl30RELcav1psmd3zgc:158370traiprelahsp90a.2PKN1TNFRSF8ppp1r13lsi:dkey-220o5.3MAP3K14cops3PSMC1nfkb2LOC564497NFKBIAcflartraddtbk1chukzgc:136584SUMO1zgc:112305tnfrsf1acasp7ripk1lLOC100005446GeneTNFCDC34smarcc1psmc3psmd6LOC564254cdc37LOC796190FLNAtraf4akpna3LOC791511birc2POLR1Apsmc2dap1aPEG3traddTRAF5traf1actl6aLOC564899kpna2mcm5faddcasp8MAP3K7IP2papolbGenerpl8birc2LOC559441IKBKEhdac1PIAS3smarcb1aBIRC3hsp90ab1CASP3akt2DBC1smarca4nr2c2wu:fc75a03zgc:158276FBXW11rpl6nfkbizck2bBCL7ARELBtraf1LOC565173zgc:66260LOC796190map3k3zgc:153048HDAC2eif4a3zgc:55886crebbpbsrcrelaHIST3H3PSMD13LOC100150926zgc:158799ptk2.1rps6kb1DPF2cyldNFKBIAYWHAZpsmd7tnfrsf1astat1arelamcm7zgc:136449GTF2ILOC100149852TNFYWHAGLOC558321NFKB1smarce1POLR1Bgnb2l1NALP4ywhahpolr1eTNFnkiras1psmd1USP2LOC100150217traf3USP11BIRC3ube2d2GeneLOC792188map3k7ip1TNFLOC796190LOC100005446nr2c2ube2iBTRCT2BPCASP8AP2DDX3gab1traf6LOC567476RELBTNFtnip1ripk3lzgc:172137ASE1zgc:162191NFKB1rps13fancd2AKAP8relahdac6gsk3bzgc:56064NFKBIAikbkgchukLOC556379YWHAQLOC100005446rpl4


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 71% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
116912view11:49, 15 May 2021EweitzModified title
108316view20:34, 6 December 2019L DupuisConverted interactions to graphical lines in legend
108151view10:36, 29 November 2019FehrhartOntology Term : 'cancer' added !
87784view11:13, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87783view11:13, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68632view04:45, 6 July 2013MaintBotUpdated to 2013 gpml schema
40798view22:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
34187view21:23, 9 December 2009MaintBotAutomatic update of empty xrefs
32336view13:31, 15 August 2009MaintBotFixed text labels
31948view13:00, 14 August 2009MaintBotFixed group labels
31380view20:40, 13 August 2009MaintBotFixed text labels
31081view01:33, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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GTF2IGeneProduct
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Gene SymbolGeneProduct
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MAP3K14GeneProduct
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NALP4GeneProduct
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Annotated Interactions

No annotated interactions
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